The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
· · COA & SDS available for every product · Same-day shipping on in-stock items GSK 2837808A - ≥98%(HPLC) , CAS No.1445879-21-9
Synonyms
3-[[3-[(Cyclopropylamino)sulfonyl]-7-(2,4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3,5-difluorophenoxy)benzoic acid
Storage
Protected from light,Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
🧪
Why this grade ≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
🌡
Storage & shipping Protected from light,Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
📋
Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
📚
Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview Product description
GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC50s of 2.6 and 43 nM for hLDHA and hLDHB, respectively.
Specifications Synonyms
3-[[3-[(Cyclopropylamino)sulfonyl]-7-(2, 4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3, 5-difluorophenoxy)benzoic acid
Specifications & Purity
≥98%(HPLC)
Biochemical and Physiological Mechanisms
Potent and selective lactate dehydrogenase A and B (LDHA and LDHB) inhibitor (IC50values are 2.6 and 43 nM for LDHA and LDHB respectively). Inhibits lactate production in selected cancer cell lines. Reduces glucose uptake and enhances mitochondrial oxygen
Storage
Protected from light, Store at -20°C, Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers Pubchem Sid 488202259 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488202259 Canonical Smiles COC1=NC(=NC=C1C2=CC3=NC=C(C(=C3C=C2)NC4=CC(=CC(=C4)C(=O)O)OC5=CC(=CC(=C5)F)F)S(=O)(=O)NC6CC6)OC IUPAC Name 3-[[3-(cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino]-5-(3,5-difluorophenoxy)benzoic acid InChIKey RZBCPMYJIARMGV-UHFFFAOYSA-N INCHI 1S/C31H25F2N5O7S/c1-43-29-25(14-35-31(37-29)44-2)16-3-6-24-26(9-16)34-15-27(46(41,42)38-20-4-5-20)28(24)36-21-7-17(30(39)40)8-22(13-21)45-23-11-18(32)10-19(33)12-23/h3,6-15,20,38H,4-5H2,1-2H3,(H,34,36)(H,39,40) Isomeric SMILES COC1=NC(=NC=C1C2=CC3=NC=C(C(=C3C=C2)NC4=CC(=CC(=C4)C(=O)O)OC5=CC(=CC(=C5)F)F)S(=O)(=O)NC6CC6)OC Molecular Weight 649.62 Reaxy-Rn 23754927 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23754927&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Quinolines and derivatives Subclass Quinoline-3-sulfonamides Intermediate Tree Nodes Not available Direct Parent Quinoline-3-sulfonamides Alternative Parents Diphenylethers Phenylpyrimidines 4-aminoquinolines Diarylethers Pyridinesulfonamides Aminobenzoic acids Benzoic acids Aniline and substituted anilines Phenoxy compounds Benzoyl derivatives Phenol ethers Fluorobenzenes Alkyl aryl ethers Aminopyridines and derivatives Organosulfonamides Primary aromatic amines Aryl fluorides Aminosulfonyl compounds Heteroaromatic compounds Amino acids Carboxylic acids Azacyclic compounds Secondary amines Hydrocarbon derivatives Organic oxides Organofluorides Molecular Framework Aromatic heteropolycyclic compounds Substituents Quinoline-3-sulfonamide - Diphenylether - 5-phenylpyrimidine - Aminoquinoline - 4-aminoquinoline - Diaryl ether - Aminobenzoic acid - Aminobenzoic acid or derivatives - Pyridine-3-sulfonamide - Benzoic acid or derivatives - Benzoic acid - Phenoxy compound - Benzoyl - Phenol ether - Aniline or substituted anilines - Fluorobenzene - Halobenzene - Aminopyridine - Alkyl aryl ether - Organosulfonic acid amide - Monocyclic benzene moiety - Aryl halide - Aryl fluoride - Benzenoid - Pyrimidine - Pyridine - Primary aromatic amine - Heteroaromatic compound - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Aminosulfonyl compound - Sulfonyl - Amino acid or derivatives - Amino acid - Carboxylic acid - Carboxylic acid derivative - Secondary amine - Azacycle - Ether - Amine - Organic oxide - Organohalogen compound - Organofluoride - Organonitrogen compound - Organic oxygen compound - Organooxygen compound - Organosulfur compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as quinoline-3-sulfonamides. These are quinolines in which the quinoline ring system is substituted by one sulfonamide group at the 3-position. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 64.96, Max Conc. mM: 100 Sensitivity light sensitive Molecular Weight 649.600 g/mol XLogP3 5.600 Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 14 Rotatable Bond Count 11 Exact Mass 649.144 Da Monoisotopic Mass 649.144 Da Topological Polar Surface Area 170.000 Ų Heavy Atom Count 46 Formal Charge 0 Complexity 1140.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator Reviews
We use cookies to ensure the website functions properly and, where permitted, to improve your experience. You can manage your preferences at any time in Settings. Learn more in our
Cookie Policy. Settings Agree All Decline
Shall we send you a message when we have discounts available?
Remind me later Allow
Thank you! Please check your email inbox to confirm.
Oops! Notifications are disabled.
Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
Copyright © 2023–present Aladdin Scientific Corp. All rights reserved.
D2308077