H 151 - Moligand™, ≥98%(HPLC) , Antagonist of stimulator of interferon response cGAMP interactor 1, CAS No.941987-60-6, Antagonist of stimulator of interferon response cGAMP interactor 1

CAS: 941987-60-6 Cat. No.: H287635 Summenformel: C₁₇H₁₇N₃O Molekulargewicht: 279.34 EG-Nummer: 845-509-6

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

1-(4-Ethylphenyl)-3-(1H-indol-3-yl)harnstoff | 3-(4-Ethylphenyl)-1-(1H-indol-3-yl)harnstoff | N-(4-Ethylphenyl)-N'-1H-indol-3-yl-harnstoff | H-151

Storage

Lagerung bei -20°C

Shipped In

Eistruhe + Eispads

Specifications

Synonyme

1-(4-Ethylphenyl)-3-(1H-indol-3-yl)harnstoff | 3-(4-Ethylphenyl)-1-(1H-indol-3-yl)harnstoff | N-(4-Ethylphenyl)-N'-1H-indol-3-yl-harnstoff | H-151

Spezifikationen & Reinheit

Moligand™, ≥98%(HPLC)

Biochemische und physiologische Mechanismen

H-151 ist ein irreversibler Antagonist des STING-Proteins (Stimulator of Interferon Genes), einer zentralen Signalkomponente des zytosolischen DNA-Sensing-Wegs. Obwohl STING ein wichtiger Bestandteil des angeborenen Immunsystems ist, hat sich gezeigt, das

Storage

Lagerung bei -20°C

Verschickt in

Eistruhe + Eispads

Note

Moligand™

Aktionsart

ANTAGONIST

Mechanismus der Wirkung

Antagonist of stimulator of interferon response cGAMP interactor 1

Reinheit

≥98%(HPLC)

Namen und Kennungen

Pubchem Sid

504764770

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504764770

Kanonisches Lächeln

CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32

IUPAC Name

1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea

InChIKey

UJZDIKVQFMCLBE-UHFFFAOYSA-N

INCHI

1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)

Isomere SMILES

CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32

Molekulargewicht

279.34

Reaxy-Rn

33196081

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=33196081&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Benzene and substituted derivatives
      • Subclass N-phenylureas

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Benzene and substituted derivatives
• Subclass: N-phenylureas
• Intermediate Tree Nodes: Not available
• Direct Parent: N-phenylureas
• Alternative Parents: Indoles Substituted pyrroles Heteroaromatic compounds Ureas Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: N-phenylurea - Indole - Indole or derivatives - Substituted pyrrole - Heteroaromatic compound - Pyrrole - Urea - Azacycle - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as n-phenylureas. These are compounds containing a N-phenylurea moiety, which is structurally characterized by a phenyl group linked to one nitrogen atom of a urea group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

TMEM173 Tchem Stimulator of interferon genes protein (0 Activities)

Discover Target: TMEM173

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HFF (3142 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Zugehörige Ziele (nicht menschlich)

MEF (1005 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Insoluble in water,Dissolved in DMSO, maximum concentration (mg/ml): 125, maximum concentration (mm): 447.48 (ultrasonic treatment required)
• Molekulargewicht: 279.340 g/mol
• XLogP3: 3.400
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 279.137 Da
• Monoisotopic Mass: 279.137 Da
• Topological Polar Surface Area: 56.900 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 352.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Häufig gestellte Fragen

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 941987-60-6, the molecular formula is C17H17N3O, and the molecular weight is 279.34 g/mol. InChIKey UJZDIKVQFMCLBE-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.