10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC 50 s of 4 and 2 nM for JAK2 and HDAC , respectively
In Vitro
JAK/HDAC-IN-1 (Compound 8m) exhibits IC 50 s of 4.8, 7.4 and 49 nM for JAK1, JAK3 and TYK2, and 14, 120, 2470 nM for HDAC2, HDAC6 and HDAC8, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:JAK2 4 nM (IC 50 ) JAK1 4.8 nM (IC 50 ) JAK3 7.4 nM (IC 50 ) Tyk2 49 nM (IC 50 ) HDAC 2 nM (IC 50 ) HDAC2 14 nM (IC 50 ) HDAC6 120 nM (IC 50 ) HDAC8 2470 nM (IC 50 )
| Isomeric SMILES | C1=CC(=CC=C1NC2=NC(=NC=C2Cl)NC3=CN(N=C3)CCCCCC(=O)NO)Cl |
|---|---|
| PubChem CID | 138377596 |
| Molecular Weight | 450.3 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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