Odronextamab (anti-CD20&CD3) - Primärer Antikörper, specific to MS4A1&CD3E, Human IgG4SP, BINDING AGENT of B-lymphocyte antigen CD20 binding agent, BINDING AGENT of B-lymphocyte antigen CD20 binding agent

CAS: 1801338-64-6 Cat. No.: Ab182836

GRADE & PURITY Animal Free, Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, ≥90%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Mensch

Reactive species

Mensch

Isotype

Human IgG4SP

Conjugation

Unconjugated

Übersicht

Odronextamab (anti-CD20&CD3) is a hinge-stabilised, fully human IgG4-based CD20 × CD3 bispecific antibody that binds CD3 on T cells and CD20 on B cells.
Purity
≥ 90% (SDS-PAGE&SEC)
Endotoxin Level
≤ 1.0EU/mg

Specifications

Product Name

Odronextamab (anti-CD20&CD3) - Primärer Antikörper, specific to MS4A1&CD3E, Human IgG4SP, BINDING AGENT of B-lymphocyte antigen CD20 binding agent

Synonyme

APY antibody | ATOPY antibody | B lymphocyte antigen CD20 antibody | B Lymphocyte Cell Surface Antigen B1 antibody | B-lymphocyte antigen CD20 antibody | B-lymphocyte cell-surface antigen B1 antibody | B-lymphocyte surface antigen B1 antibody | B1 antibod

Spezifikationen & Reinheit

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA

Wirtsspezies

Mensch

Spezifität

MS4A1&CD3E

Konjugation

Unconjugated

Note

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Aktionsart

BINDING AGENT

Mechanismus der Wirkung

BINDING AGENT of B-lymphocyte antigen CD20 binding agent

Isotyp

Human IgG4SP

Lichterketten-Typ

kappa

SDS-PAGE

145.32 kDa

Verfahren zur Reinigung

Protein A purified

Konzentration

See COA

CAS

1801338-64-6

Product Line

biological_products

Lagerung und Versand

Storage

Store at -80°C,Avoid repeated freezing and thawing

Verschickt in

Dry ice packs + Cold packs

Stabilität und Lagerung

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Bilder

Flow Cytometry: Odronextamab (anti-CD20&CD3) (Ab182836)

Odronextamab (anti-CD20&CD3) (Ab182836) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD20&CD3 with Odronextamab (anti-CD20&CD3) (Ab182836) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Odronextamab (anti-CD20&CD3) (Ab182836)

Odronextamab (anti-CD20&CD3) (Ab182836) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD20&CD3 (red) with Odronextamab (anti-CD20&CD3) (Ab182836) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Odronextamab (anti-CD20&CD3) (Ab182836)

Odronextamab (anti-CD20&CD3) (Ab182836) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD20&CD3 (red) with Odronextamab (anti-CD20&CD3) (Ab182836) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Odronextamab (anti-CD20&CD3) (Ab182836)

Odronextamab (anti-CD20&CD3) (Ab182836) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD3 (red) with Odronextamab (anti-CD20&CD3) (Ab182836) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

ELISA: Odronextamab (anti-CD20&CD3) (Ab182836)

Odronextamab (anti-CD20&CD3) (Ab182836) - ELISA
Immobilized Recombinant Hu-CD20-VLP protein at 2.0 μg/mL can bind Odronextamab (anti-CD20&CD3) (Ab182836) with the EC₅₀ of 45.99 ng/mL.

SEC: Odronextamab (anti-CD20&CD3) (Ab182836)

Odronextamab (anti-CD20&CD3) (Ab182836) - SEC
The purity of Odronextamab (anti-CD20&CD3) (Ab182836) is more than 95% verified by HPLC.

Häufig gestellte Fragen

What does Animal Free mean?

Animal Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

What does Carrier Free mean?

Carrier Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

How should this product be stored?

Store at ?80 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1801338-64-6.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

Which species reactivity has this antibody been validated against?

Validated reactivity is listed on the PDP and on each lot's datasheet. We validate against the most commonly tested species for the target (Odronextamab (anti-CD20&CD3)); cross-reactivity in untested species may exist but is not guaranteed. Contact technical support for specific species inquiries.