Phenytoin - Moligand™, 10mM in DMSO , Channel blocker of Na v1.2, CAS No.57-41-0, Channel blocker of Na v1.2

CAS: 57-41-0 Cat. No.: P408649 Molecular Weight: 252.27 EC Number: 200-328-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Diphenylhydantoin | 5,​5-​diphenyl-2,​4-​imidazolidinedione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Phenytoin Phenytoin (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.
In vitro

In vivo

Cell Data

cell lines：MM.1S, MM.1R, RPMI8226, U266, RPMI8266, RPMI-Dox40, OPM1 cells, primary MM cells and PBMNCs

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Diphenylhydantoin | 5, ​5-​diphenyl-2, ​4-​imidazolidinedione

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Phenytoin (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

CHANNEL BLOCKER

Mechanism of action

Channel blocker of Na v1.2

Product Properties

• ALogP: 2.5

Names and Identifiers

• Isomeric SMILES: C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3
• UN Number: 2811
• Packing Group: I
• Molecular Weight: 252.27
• Reaxy-Rn: 384532
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=384532&ln=

Associated Targets(Human)

SCN2A Tclin Sodium channel protein type 2 subunit alpha (2 Activities)

Discover Target: SCN2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Melt Point(°C): 293-295 °C

References

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3. Wei Li, Zhen Wang, Xiaoyu Wang, Xiaowei Cao, Caili Bi, Lili Jiang, Shuna Cui, Yong Liu.  (2021)  Risk prediction of drug-drug interaction potential of phenytoin and miconazole topical formulations.  CHEMICO-BIOLOGICAL INTERACTIONS,      [PMID:33961833] [10.1016/j.cbi.2021.109498]

4. Mengtian Jia, Yanyan Zhu, Dong Guo, Xiaogang Bi, Xiaohong Hou.  (2020)  Surface molecularly imprinted polymer based on core-shell Fe3O4@MIL-101(Cr) for selective extraction of phenytoin sodium in plasma.  ANALYTICA CHIMICA ACTA,      [PMID:32825905] [10.1016/j.aca.2020.06.075]

5. Jing-Xian Zhang, Mei-Juan Qi, Mei-Zhi Shi, Jun-Jun Chen, Xiang-Qi Zhang, Jiao Yang, Ke-Zhi Zhang, Yong-Long Han, Cheng Guo.  (2018)  Effects of Danhong injection, a traditional Chinese medicine, on nine cytochrome P450 isoforms in vitro.  BIOMEDICAL CHROMATOGRAPHY,  33  (4): (e4454).  [PMID:30520061] [10.1002/bmc.4454]

6. Suqian Xu, Hanxu Zhu, Wenrui Cao, Zhibin Wen, Jinnan Wang, Corvini Philippe François-Xavier, Thomas Wintgens.  (2018)  Cu-Al2O3-g-C3N4 and Cu-Al2O3-C-dots with dual-reaction centres for simultaneous enhancement of Fenton-like catalytic activity and selective H2O2 conversion to hydroxyl radicals.  APPLIED CATALYSIS B-ENVIRONMENTAL,      [PMID:] [10.1016/j.apcatb.2018.04.029]

7. Wang Weixue, Liu Yang, Du Xinjie, Wang Huihui, Ai Yuejie, Liu Qianwei, Wang Xiangke, Chen Zhe.  (2025)  Solvent-free fabrication of ultrathin two-dimensional metal oxides/sulfides in a fixed interlayer by geometric confinement.  Nature Communications,  16  (1): (1-11).  [PMID:39948342] [10.1038/s41467-025-56912-9]