Propafenone HCl - ≥98% , Beta-1 adrenergic receptor antagonist, CAS No.34183-22-7, Beta-1 adrenergic receptor antagonist

CAS: 34183-22-7 Cat. No.: P129542 Summenformel: C₂₁H₂₇NO₃·HCl Molekulargewicht: 377.9 EG-Nummer: 251-867-9

GRADE & PURITY ≥98%

Synonyms

Arythmol | Pronon | Rhythmonorm | PROPAFENONE HYDROCHLORIDE | Rythmol | Propafenon hydrochlorid | Rytmonorm | 1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one hydrochloride | Rythmol SR

Storage

Store at 2-8°C,Argon charged

Shipped In

Wet ice

Übersicht

Propafenone HCl is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.

Specifications

Synonyme

Arythmol | Pronon | Rhythmonorm | PROPAFENONE HYDROCHLORIDE | Rythmol | Propafenon hydrochlorid | Rytmonorm | 1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one hydrochloride | Rythmol SR

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

Propafenone Hydrochloride is a sodium channel protein inhibitor. Propafenone Hydrochloride is an inhibitor of AR.Na + , Ca 2+ and K + channel blocker. Suppresses atrial fibrillation in vivo . Blocks ATP-sensitive K + channels reversibly and voltage-indepe

Storage

Store at 2-8°C,Argon charged

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

ANTAGONIST

Mechanismus der Wirkung

Beta-1 adrenergic receptor antagonist

Hinweis

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Reinheit

≥98%

Namen und Kennungen

• Pubchem Sid: 504753556
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504753556
• Kanonisches Lächeln: CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O.Cl
• IUPAC Name: 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride
• InChIKey: XWIHRGFIPXWGEF-UHFFFAOYSA-N
• INCHI: 1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
• Isomere SMILES: CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O.Cl
• WGK Deutschland: 3
• RTECS: UH2833000
• Molekulargewicht: 377.9
• Reaxy-Rn: 4343069
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4343069&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Klasse Linear 1,3-diarylpropanoids

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Klasse: Linear 1,3-diarylpropanoids
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Linear 1,3-diarylpropanoids
• Alternative Parents: Alkyl-phenylketones Butyrophenones Phenoxy compounds Phenol ethers Benzoyl derivatives Aryl alkyl ketones Alkyl aryl ethers Secondary alcohols 1,2-aminoalcohols Dialkylamines Organopnictogen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Linear 1,3-diarylpropanoid - Alkyl-phenylketone - Butyrophenone - Phenylketone - Phenoxy compound - Benzoyl - Phenol ether - Aryl alkyl ketone - Aryl ketone - Alkyl aryl ether - Monocyclic benzene moiety - Benzenoid - 1,2-aminoalcohol - Ketone - Secondary alcohol - Ether - Secondary aliphatic amine - Secondary amine - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Alcohol - Organic oxide - Organopnictogen compound - Organic oxygen compound - Amine - Organic nitrogen compound - Hydrochloride - Aromatic homomonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as linear 1,3-diarylpropanoids. These are organic compounds with a structure based on a C6-C3-C6 skeleton, where the two benzene rings are not linked together.
• External Descriptors: hydrochloride

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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KCNH2 Tclin HERG (29587 Activities)

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ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

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GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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HEK293 (82097 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

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PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

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TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)

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Plasmodium falciparum (966862 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in methanol (50 mg/ml), water(slightly soluble in cold water), ethanol, acetone, and chloroform
• Empfindlichkeit: Moisture sensitive
• Schmelzpunkt (°C): 172-175°C
• Molekulargewicht: 377.900 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 11
• Exact Mass: 377.176 Da
• Monoisotopic Mass: 377.176 Da
• Topological Polar Surface Area: 58.600 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 368.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Referenzen

1. Zhang Yuecheng, Zhang Jie, Sun Lingbo, Tian Rui, Ma Hongyan.  (2022)  Ratiometric detection of propafenone hydrochloride with one-pot synthesized dual emissive carbon dots.  CHEMICAL PAPERS,  77  (1): (375-383).  [PMID:] [10.1007/s11696-022-02489-2]