≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
RAS inhibitor Abd-7, a potent RAS-binding compound ( K d =51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K , CRAF and RALGDS as well as NRAS Q61H and HRAS G12V.
In Vitro
RAS inhibitor Abd-7 (0-20 μM; 24-48 hours) is a cell-potent inhibitor affecting the viability of cancer cell lines in a single digit to low micromolar range. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: DLD-1 cells, HT1080 cells Concentration: 0-20 μM Incubation Time: 24-48 hours Result: The IC 50 of 8 μM in DLD-1 and 10 μM in HT1080 at 72 h (similar values for the IC 50 were found after 48 h).
Form:Solid
| Canonical Smiles | CN(C)CC1=CC=C(C=C1)NC2=C(N=C(C=C2)C3=C4C(=CC=C3)OCCO4)OC |
|---|---|
| IUPAC Name | 6-(2,3-dihydro-1,4-benzodioxin-5-yl)-N-[4-[(dimethylamino)methyl]phenyl]-2-methoxypyridin-3-amine |
| InChIKey | MJHHFDJNRRCUOB-UHFFFAOYSA-N |
| INCHI | 1S/C23H25N3O3/c1-26(2)15-16-7-9-17(10-8-16)24-20-12-11-19(25-23(20)27-3)18-5-4-6-21-22(18)29-14-13-28-21/h4-12,24H,13-15H2,1-3H3 |
| Isomeric SMILES | CN(C)CC1=CC=C(C=C1)NC2=C(N=C(C=C2)C3=C4C(=CC=C3)OCCO4)OC |
| PubChem CID | 134812710 |
| Molecular Weight | 391.46 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Benzodioxanes |
| Subclass | Benzo-1,4-dioxanes |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Benzo-1,4-dioxanes |
| Alternative Parents | Phenylmethylamines Benzylamines Aniline and substituted anilines Aralkylamines Aminopyridines and derivatives Alkyl aryl ethers Para dioxins Heteroaromatic compounds Trialkylamines Secondary amines Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Benzo-1,4-dioxane - Aniline or substituted anilines - Phenylmethylamine - Benzylamine - Aralkylamine - Aminopyridine - Alkyl aryl ether - Benzenoid - Pyridine - Para-dioxin - Monocyclic benzene moiety - Heteroaromatic compound - Tertiary aliphatic amine - Tertiary amine - Oxacycle - Azacycle - Secondary amine - Ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Amine - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as benzo-1,4-dioxanes. These are heterocyclic compounds containing a benzene ring fused to a 1,4-dioxane ring. |
| External Descriptors | Not available |
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| Solubility | DMSO : 125 mg/mL (319.32 mM; Need ultrasonic) H2O : <0.1 mg/mL (insoluble) |
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