Recombinant ERBB2/HER2 Antibody - Primärer Antikörper, specific to ERBB2/HER2/CD340, Antibody of erb-b2 receptor tyrosine kinase 2, Antibody of erb-b2 receptor tyrosine kinase 2

CAS: 180288-69-1 Cat. No.: Ab304367 Summenformel: C₆₄₇₀H₁₀₀₁₂N₁₇₂₆O₂₀₁₃S₄₂ Molekulargewicht: 145531.50 EG-Nummer: 695-702-2

GRADE & PURITY Animal Free, Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, PBS Only, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Mensch

Reactive species

Maus, Mensch

Isotype

Human IgG1

Conjugation

Unconjugated

Übersicht

Trastuzumab (anti-HER2) is a humanized IgG1 monoclonal antibody that selectively binds to HER2 with high affinity. Trastuzumab (anti-HER2) has the potential for HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastric Cancer research.

Specifications

Product Name

Recombinant ERBB2/HER2 Antibody - Primärer Antikörper, specific to ERBB2/HER2/CD340, Antibody of erb-b2 receptor tyrosine kinase 2

Synonyme

Herceptin | Recombinant Trastuzumab Antibody | Anti-Human HER2, Humanized Antibody | Trastuzumab (Anti-Human HER2, Humanized Antibody) | Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody | Cerb

Spezifikationen & Reinheit

Animal Free,Carrier Free,Recombinant,ExactAb™,Low Endotoxin,Azide Free,Validated,PBS Only,≥95%(SDS-PAGE&SEC-HPLC),See COA

Biochemische und physiologische Mechanismen

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a

Wirtsspezies

Mensch

Spezifität

ERBB2/HER2/CD340

Konjugation

Unconjugated

Note

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, PBS Only, Recombinant, Validated

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Antibody of erb-b2 receptor tyrosine kinase 2

Lichterketten-Typ

kappa

SDS-PAGE

26.0 kDa (Light Chain) & 50.6 kDa (Heavy Chain), under reducing conditions; 188.5 kDa, under non-reducing conditions.

Verfahren zur Reinigung

Protein A purified

Konzentration

See COA

CAS

180288-69-1

Product Line

Biologische Produkte

Lagerung und Versand

Form

Liquid

Storage

Store at -80°C,Avoid repeated freezing and thawing

Verschickt in

Dry ice packs + Cold packs

Stabilität und Lagerung

Store at 2-8℃ short term (1-2 weeks). Store at -80℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Bilder

Flow Cytometry: Trastuzumab (anti-HER2) (T411999)

Trastuzumab (anti-HER2) (T411999) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling HER2 (red) with Trastuzumab (anti-HER2) (T411999). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Trastuzumab (anti-HER2) (T411999)

Trastuzumab (anti-HER2) (T411999) - SEC
The purity of Trastuzumab (anti-HER2) (T411999) is more than 95% verified by HPLC.

Flow Cytometry: Trastuzumab (anti-HER2) (T411999)

Trastuzumab (anti-HER2) (T411999) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling HER2 (red) with Trastuzumab (anti-HER2) (T411999) at 1.0 μg/mL for 1 hour at 4°C and detected with Alexa Fluor 488 - conjugated affinipure goat anti - Human IgG. Blue - Human IgG Isotype Control Antibody (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Klasse Purine nucleosides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Klasse: Purine nucleosides
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Purine nucleosides
• Alternative Parents: Glycosylamines 6-oxopurines Pentoses Hypoxanthines Pyrimidones Aminopyrimidines and derivatives Aminoimidazoles N-substituted imidazoles Vinylogous amides Tetrahydrofurans Heteroaromatic compounds Secondary alcohols Oxacyclic compounds Azacyclic compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds Primary alcohols Primary amines
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Purine nucleoside - Glycosyl compound - N-glycosyl compound - 6-oxopurine - Pentose monosaccharide - Hypoxanthine - Purinone - Imidazopyrimidine - Purine - Aminopyrimidine - Pyrimidone - Aminoimidazole - N-substituted imidazole - Monosaccharide - Pyrimidine - Azole - Tetrahydrofuran - Vinylogous amide - Imidazole - Heteroaromatic compound - Secondary alcohol - Oxacycle - Azacycle - Organoheterocyclic compound - Primary amine - Amine - Alcohol - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Primary alcohol - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as purine nucleosides. These are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 (0 Activities)

Discover Target: ERBB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB2 Tclin Epidermal growth factor receptor and ErbB2 (HER1 and HER2) (186 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB2 Tclin Epidermal growth factor receptor (487 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB2 Tclin FASN/HER2 (2 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

What does Animal Free mean?

Animal Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

What does Carrier Free mean?

Carrier Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 180288-69-1. InChIKey FNXPTCITVCRFRK-UMMCILCDSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

Which species reactivity has this antibody been validated against?

Validated reactivity is listed on the PDP and on each lot's datasheet. We validate against the most commonly tested species for the target (Recombinant ERBB2/HER2 Antibody); cross-reactivity in untested species may exist but is not guaranteed. Contact technical support for specific species inquiries.