Ruplizumab (anti-CD40L) - Primärer Antikörper, specific to CD40LG, Human IgG1, INHIBITOR of CD40 ligand inhibitor, INHIBITOR of CD40 ligand inhibitor

CAS: 220651-94-5 Cat. No.: Ab183448
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GRADE & PURITY Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
Application
Animal Model, ELISA, Flow Cytometry, Functional Assay
Host species
Mensch
Reactive species
Mensch
Isotype
Human IgG1
Conjugation
Unconjugated
Size
Deutschland (EU)
USA*
Price
Qty
100μg
Ab183448-100μg
Auf Lager ≥10
100,57€
1mg
Ab183448-1mg
4 Auf Lager
496,26€
5mg
Ab183448-5mg
1 Auf Lager
1.287,64€
10mg
Ab183448-10mg
Auf Bestellung · 8–12 Wochen
2.061,66€
Enter a quantity for the sizes you want to add.
🧪

Why this grade

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA Animal Free,Azide Free,Carrier Free,ExactAb™,Low Endotoxin,Recombinant,Validated for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -80°C,Avoid repeated freezing and thawing Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Übersicht

Ruplizumab (anti-CD40L) is a humanized monoclonal anti-CD40L (TNF Receptor) IgG1κ antibody. Ruplizumab (anti-CD40L) has the potential for systemic lupus erythematosus disease research.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Specifications

Product Name
Ruplizumab (anti-CD40L) - Primärer Antikörper, specific to CD40LG, Human IgG1, INHIBITOR of CD40 ligand inhibitor
Synonyme
CD154 antibody | CD40 antigen ligand antibody | CD40 ligand antibody | CD40-L antibody | CD40L antibody | CD40L_HUMAN antibody | CD40LG antibody | gp39 antibody | hCD40L antibody | HIGM1 antibody | IGM antibody | IMD3 antibody | soluble form antibody | T
Spezifikationen & Reinheit
Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Wirtsspezies
Mensch
Spezifität
CD40LG
Konjugation
Unconjugated
Note
Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Aktionsart
INHIBITOR
Mechanismus der Wirkung
INHIBITOR of CD40 ligand inhibitor
Isotyp
Human IgG1
Lichterketten-Typ
kappa
SDS-PAGE
26.2 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 191.6 kDa, under non-reducing conditions.
Verfahren zur Reinigung
Protein A purified
Konzentration
See COA
CAS
220651-94-5
Lagerung und Versand
Form
Liquid
Storage
Store at -80°C,Avoid repeated freezing and thawing
Verschickt in
Dry ice packs + Cold packs
Stabilität und Lagerung
Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
Bilder

Ruplizumab (anti-CD40L) (Ab183448) - ELISA
Immobilized Recombinant Human CD40 Ligand protein (rp169583) at 2.0 μg/mL can bind Ruplizumab (anti-CD40L) (Ab183448) with the EC50 of 24.77 ng/mL.

Ruplizumab (anti-CD40L) (Ab183448) - Flow Cytometry
pLVX-puro-SYMX10-TNFSF5 (CD40L) - FL - HEK293 cells were stained with Ruplizumab (anti-CD40L) (Ab183448) and negative control protein respectively, washed and then followed by PE and analyzed with the FACS EC50 is 0.23 nM.

Ruplizumab (anti-CD40L) (Ab183448) - SEC
The purity of Ruplizumab (anti-CD40L) (Ab183448) is more than 95% verified by HPLC.

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Zugehörige Ziele (menschlich)
CD40LG Tbio CD40 ligand (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Wirkungsmechanismen
Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate TypeDatumArtikel
ZJ24F0708357Certificate of AnalysisMay 19, 2026 Ab183448
ZJ24F0708358Certificate of AnalysisMay 19, 2026 Ab183448
ZJ24F0708359Certificate of AnalysisMay 19, 2026 Ab183448
Lösungsrechner
Bewertungen

Kundenbewertungen

Need help choosing the grade?

Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.

View Animal Free grade guide → View Carrier Free grade guide → View Recombinant grade guide → View Validated grade guide → View ExactAb™ grade guide → View Low Endotoxin grade guide → View Azide Free grade guide →

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