Serplulimab (anti-PDCD1) - Primärer Antikörper, specific to PDCD1, >95%, Human IgG4SP, ANTAGONIST of Programmed cell death protein 1 antagonist, ANTAGONIST of Programmed cell death protein 1 antagonist

CAS: 2231029-82-4 Cat. No.: Ab176173

GRADE & PURITY Animal Free, Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Mensch

Reactive species

Cynomolgus-Affe, Mensch

Isotype

Human IgG4SP

Conjugation

Unconjugated

Übersicht

Serplulimab (anti-PDCD1) is humanized monoclonal anti-PD-1 antibody. Serplulimab (anti-PDCD1) can be used in research of small cell lung cancer.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Specifications

Product Name

Serplulimab (anti-PDCD1) - Primärer Antikörper, specific to PDCD1, >95%, Human IgG4SP, ANTAGONIST of Programmed cell death protein 1 antagonist

Synonyme

CD279 antibody | CD279 antigen antibody | hPD 1 antibody | hPD l antibody | hPD-1 antibody | hSLE1 antibody | PD 1 antibody | PD-1 antibody | PD1 antibody | PDCD 1 antibody | PDCD1 antibody | PDCD1_HUMAN antibody | Programmed cell death 1 antibody | Progr

Spezifikationen & Reinheit

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Wirtsspezies

Mensch

Spezifität

PDCD1

Konjugation

Unconjugated

Note

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Aktionsart

ANTAGONIST

Mechanismus der Wirkung

ANTAGONIST of Programmed cell death protein 1 antagonist

Isotyp

Human IgG4SP

Lichterketten-Typ

kappa

SDS-PAGE

27.1 kDa (Light Chain) & 51.9 kDa (Heavy Chain), under reducing conditions; 180.9 kDa, under non-reducing conditions.

Verfahren zur Reinigung

Protein A purified

Reinheit

>95%

Konzentration

See COA

CAS

2231029-82-4

Product Line

biological_products

Lagerung und Versand

Form

Liquid

Storage

Store at -80°C,Avoid repeated freezing and thawing

Verschickt in

Dry ice packs + Cold packs

Stabilität und Lagerung

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Bilder

SEC: Serplulimab (anti-PDCD1) (Ab176173)

Serplulimab (anti-PDCD1) (Ab176173) - SEC
The purity of Serplulimab (anti-PDCD1) (Ab176173) is more than 95% verified by HPLC.

Flow Cytometry: Serplulimab (anti-PDCD1) (Ab176173)

Serplulimab (anti-PDCD1) (Ab176173) - Flow Cytometry
Flow Cytometry analysis of 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated Jurkat cells (24h) labelling PDCD1 (red) with Serplulimab (anti-PDCD1) (Ab176173). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

ELISA: Serplulimab (anti-PDCD1) (Ab176173)

Serplulimab (anti-PDCD1) (Ab176173) - ELISA
Immobilized Recombinant Human PD-1 Protein (rp176241) at 2.0 μg/mL can bind Serplulimab (anti-PDCD1) (Ab176173) with the EC₅₀ of 59.84 ng/mL.

Zugehörige Ziele (menschlich)

PDCD1 Tclin Programmed cell death protein 1 (0 Activities)

Discover Target: PDCD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDCD1 Tclin Programmed cell death protein 1 (14 Activities)

Discover Target: PDCD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Häufig gestellte Fragen

What does Animal Free mean?

Animal Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

What does Carrier Free mean?

Carrier Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

How should this product be stored?

Store at ?80 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2231029-82-4.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

Which species reactivity has this antibody been validated against?

Validated reactivity is listed on the PDP and on each lot's datasheet. We validate against the most commonly tested species for the target (Serplulimab (anti-PDCD1)); cross-reactivity in untested species may exist but is not guaranteed. Contact technical support for specific species inquiries.