tBID - Moligand™,10mM in DMSO , CAS No.1639895-85-4

CAS: 1639895-85-4 Cat. No.: T656448 Molecular Weight: 528.78

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 ( HIPK2 ) with an IC 50 of  0.33 µM.

In Vitro

Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival. TBID, displays toward HIPK2 unprecedented efficacy (IC 50 =0.33 µM) and selectivity (Gini coefficient 0.592 out of a panel of 76 kinases). The two other members of the HIPK family, HIPK1 and HIPK3, are also inhibited by TBID albeit less efficiently than HIPK2. The mode of action of TBID is competitive with respect to ATP, consistent with modelling. TBID interacts with the hinge region through hydrophobic interactions between Val 213, Val 261, Phe 277, Leu 280, Met 331, Ile 345, and the tetrabromine moiety, while the symmetric nitrogen atom at position 3 interacts with the catalytic Lys 228, thus playing a crucial role in the binding architecture. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 0.33 µM (HIPK2)

Specifications

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 ( HIPK2 ) with an IC 50 of u200a0.33 µM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Names and Identifiers

• Molecular Weight: 528.78