2 M in THF for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature Ships Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
General Description
Trimethyl(trifluoromethyl)silane (TMSCF 3.Flammable liquid ) is also called as Ruppert-Prakash fluorination reagent. It is extensively used for the synthesis of trifluoromethyl-containing compounds.
Application
Reactant for: Silver-mediated C-H trifluoromethylation of arenes Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8 Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts Palladium-catalyzed oxidative trifluoromethylation of indoles Preparation of 5-HT1A antagonists Used as difluorocarbene source TMSCF 3.Flammable liquid can be used as a reagent for: Conversion of aromatic aldehydes to difluoromethylated products. C-H trifluoromethylation of arenes, terminal alkynes, tertiary amines, heteroarenes, allylic, and terminal alkenes using metal catalyst or metal free oxidative trifluoromethylation reaction. It can also be used in trifluoromethylation of: Non-activated aldimines. Heterocumulenes. Azomethine imines.
| Canonical Smiles | C[Si](C)(C)C(F)(F)F |
|---|---|
| IUPAC Name | trimethyl(trifluoromethyl)silane |
| InChIKey | MWKJTNBSKNUMFN-UHFFFAOYSA-N |
| INCHI | 1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3 |
| Isomeric SMILES | C[Si](C)(C)C(F)(F)F |
| WGK Germany | 3 |
| UN Number | 1993 |
| Molecular Weight | 142.19 |
| Beilstein | 4241868 |
| Reaxy-Rn | 4241868 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organohalogen compounds |
| Class | Alkyl halides |
| Subclass | Halomethanes |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Trihalomethanes |
| Alternative Parents | Organic metalloid salts Organofluorides Hydrocarbon derivatives Alkylsilanes Alkyl fluorides |
| Molecular Framework | Aliphatic acyclic compounds |
| Substituents | Trihalomethane - Organic metalloid salt - Hydrocarbon derivative - Organic salt - Organosilicon compound - Alkylsilane - Organofluoride - Alkyl fluoride - Aliphatic acyclic compound |
| Description | This compound belongs to the class of organic compounds known as trihalomethanes. These are organic compounds in which exactly three of the four hydrogen atoms of methane (CH4) are replaced by halogen atoms. |
| External Descriptors | Not available |
| Refractive Index | 1.33 |
|---|---|
| Flash Point(°F) | 1.4 °F |
| Flash Point(°C) | -17℃ |
| Boil Point(°C) | 54-55 °C |
| Molecular Weight | 142.190 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 0 |
| Exact Mass | 142.043 Da |
| Monoisotopic Mass | 142.043 Da |
| Topological Polar Surface Area | 0.000 Ų |
| Heavy Atom Count | 8 |
| Formal Charge | 0 |
| Complexity | 78.300 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Hui Han, Ying-Ying Wang, Xing-Chao Yu, Yan-Na Ma, Xuenian Chen. (2022) A Simple and Efficient Way to Directly Synthesize Unsolvated Alkali Metal (M = Na, K) Salts of [CB11H12]−. Crystals, 12 (10): (1339). [PMID:] [10.3390/cryst12101339] |
| 2. Ma Baochen, Zhang Haikuo, Li Ruhong, Zhang Shuoqing, Chen Long, Zhou Tao, Wang Jinze, Zhang Ruixin, Ding Shouhong, Xiao Xuezhang, Deng Tao, Chen Lixin, Fan Xiulin. (2024) Molecular-docking electrolytes enable high-voltage lithium battery chemistries. Nature Chemistry, [PMID:39009795] [10.1038/s41557-024-01585-y] |
| 3. Chun Li, Jiaxun Yao, Jiayi Xu, Huanhuan Yang, Guangfu Luo, Yanhao Yu. (2025) Burst Nucleation in Area-Selective Atomic Layer Deposition. ACS Applied Materials & Interfaces, [PMID:40663797] [10.1021/acsami.5c07184] |
| 4. Li Ruhong, Zhang Haikuo, Zhang Shuoqing, Li Yong, Guo Rui, Pei Haijuan, Yang Ming, Zhang Junbo, Chen Long, Xiao Xuezhang, Chen Lixin, Shen Yanbin, Deng Tao, Fan Xiulin. (2025) Unified affinity paradigm for the rational design of high-efficiency lithium metal electrolytes. Nature Energy, [PMID:] [10.1038/s41560-025-01842-5] |
