1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (ammonium salt) - ≥99% , CAS No.474922-26-4

CAS: 474922-26-4 Cat. No.: D130802 PubChem CID: 156592378

GRADE & PURITY ≥99%

Synonyms

DSPE-PEG(2000) Amine | DSPE-PEG-NH2 | DSPE-PEG2000-NH2 | PD070000 | DSPE-PEG-Amine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Application

Drug Delivery, Surface Modification, PEGylation of Protein, Peptide & Oligo

Specifications

Synonyms

DSPE-PEG(2000) Amine | DSPE-PEG-NH2 | DSPE-PEG2000-NH2 | PD070000 | DSPE-PEG-Amine

Specifications & Purity

≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)OCCOCCN)OC(=O)CCCCCCCCCCCCCCCCC.N
• IUPAC Name: [3-[2-[2-(2-aminoethoxy)ethoxycarbonylamino]ethoxy-hydroxyphosphoryl]oxy-2-octadecanoyloxypropyl] octadecanoate;azane
• InChIKey: AXHRCGLQEUQOIS-UHFFFAOYSA-N
• INCHI: 1S/C46H91N2O11P.H3N/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-44(49)56-41-43(42-58-60(52,53)57-38-36-48-46(51)55-40-39-54-37-35-47)59-45(50)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h43H,3-42,47H2,1-2H3,(H,48,51)(H,52,53);1H3
• Isomeric SMILES: CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)OCCOCCN)OC(=O)CCCCCCCCCCCCCCCCC.N
• PubChem CID: 156592378

References

1. Yan-ming Xia, Li-xin Hu, Yun-han Xia, Shi-xuan Li, Bo Shi, Chao Qin, Xiao-peng Han, Su-xin Li, Li-fang Yin.  (2023)  Rational surface modification of zirconium-based metal–organic framework nanomaterials for the adsorption and recovery of coloured drugs and proteins from aqueous solutions.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2023.132845]

2. Minghua Zhou, Beibei Tian, Yingcui Bu, Zhichao Wu, Jianhua Yu, Sen Wang, Xianshun Sun, Xiaojiao Zhu, Hongping Zhou.  (2023)  Enhanced pH-Responsive Chemo/Chemodynamic Synergistic Cancer Therapy Based on In Situ Cu2+ Di-Chelation.  ACS Applied Bio Materials,      [PMID:37428493] [10.1021/acsabm.3c00323]

3. Huaming He, Fang Zhao, Wukun Zhong, Yuling Yang, Yuhong Lin, Yihang Ding, Jiajia Yang, Chunhua Lu, Xiankun Tu.  (2022)  GSH-responsive sequential mitochondria-targeting nanoagents for photothermal-enhanced chemodynamic therapy.  MATERIALS & DESIGN,      [PMID:] [10.1016/j.matdes.2022.110722]

4. Xiangqi Liu, Wei Feng, Huijing Xiang, Baihui Liu, Mujie Ye, Meng Wei, Rui Dong, Yu Chen, Kuiran Dong.  (2021)  Multifunctional cascade nanocatalysts for NIR-II-synergized photonic hyperthermia-strengthened nanocatalytic therapy of epithelial and embryonal tumors.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2020.128364]

5. Zhaoming Guo, Yi Zhang, Yuwei Gong, Guqing Li, Jiawei Pan, Danni Dou, Kun Ma, Changhao Cui, Yubo Liu, Xudong Zhu.  (2025)  Antibody functionalized curcuma-derived extracellular vesicles loaded with doxorubicin overcome therapy-induced senescence and enhance chemotherapy.  JOURNAL OF CONTROLLED RELEASE,      [PMID:39814319] [10.1016/j.jconrel.2025.01.029]

6. Ming-Yuan Yang, Meng-Meng Han, Ling Tang, Yu-Yang Bi, Xue-Na Li, Jee-Heon Jeong, Yi Wang, Hu-Lin Jiang.  (2024)  Dual Barrier-Penetrating Inhaled Nanoparticles for Enhanced Idiopathic Pulmonary Fibrosis Therapy.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202315128]

7. Xufeng Lu, Xiaodong Chen, Chengyin Lin, Yongdong Yi, Shengsheng Zhao, Bingzi Zhu, Wenhai Deng, Xiang Wang, Zuoliang Xie, Shangrui Rao, Zhonglin Ni, Tao You, Liyi Li, Yingpeng Huang, Xiangyang Xue, Yaojun Yu, Weijian Sun, Xian Shen.  (2024)  Elesclomol Loaded Copper Oxide Nanoplatform Triggers Cuproptosis to Enhance Antitumor Immunotherapy.  Advanced Science,      [PMID:38430531] [10.1002/advs.202309984]

8. Hafza Behroz Mehvish, Shirong Zhang, Yi Liang, Da Sun, Xu Qiu, Kai Qu, Xian Qin, Jiawei Li, Fei Yan, Chunhui Lang, Lixin Xu, Guixue Wang, Jian Chen, Bo He, Kun Zhang, Wei Wu.  (2025)  Enhanced Osteoporosis Treatment via Nano Drug Coating Encapsulating Lactobacillus rhamnosus GG.  ACS Applied Materials & Interfaces,      [PMID:39789866] [10.1021/acsami.4c17985]

9. Yao Zuo, Hongwen Li, Xiaochao Wang, Yejin Liang, Caihong Huang, Guanye Nai, Jingrong Ruan, Wenzheng Dong, Xiang Lu.  (2024)  Inhibition of JAK/STAT3 Expression by Acute Myeloid Leukemia-Targeted Nanoliposome for Chemotherapy Enhancement.  ACS Omega,      [PMID:39281932] [10.1021/acsomega.4c00710]

10. Xiaojuan Hu, Danping Wu, Shijie Yao, Gongning Chen, Ping Li, Yang Chen, Wancheng Gong, Weijiao Fan, Xiaoyi Chen, Xiaozhou Mou, Yu Cai, Xianghong Yang.  (2024)  Platelet membrane coated Cu9S8-SNAP for NIR-II photoacoustic imaging guided NO repairing acute kidney injury.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.153324]

11. Danping Wu, Xiaoyi Chen, Shijie Yao, Yichen He, Gongning Chen, Xiaojuan Hu, Yang Chen, Zhenye Lv, Jing Yu, Ketao Jin, Yu Cai, Xiaozhou Mou.  (2024)  Platelet Membrane Coated Cu9S8-SNAP for Targeting NIR-II Mild Photothermal Enhanced Chemodynamic/Gas Therapy of Triple-Negative Breast Cancer.  Small,      [PMID:38639010] [10.1002/smll.202400919]

12. Jian Cui, Zhiwei Wen, Huajie Huang, Shuilin Qin, Yanjie Luo, Wei Zhang, Wei Wu.  (2024)  The Pharmacokinetics and Liver-Targeting Evaluation of Silybin Liposomes Mediated by the NTCP/OCTN2 Dual Receptors.  MOLECULAR PHARMACEUTICS,      [PMID:39370820] [10.1021/acs.molpharmaceut.3c01245]

13. Shu Lou, Changyue Xing, Jiarong Zhang, Qifei Yang, Wentao Wang, Yuxing Qian, Ben Zhong Tang, Ming Zhang, Yongchu Pan.  (2025)  Efficient organic nanoparticles for photothermal antibacterial activity and immune regulation to promote maxillofacial wound healing and scarless repair.  BIOMATERIALS,      [PMID:40618450] [10.1016/j.biomaterials.2025.123534]

14. Xu Jia, Deng Cheng, Gao Tang, He Mengrong, Fu Wenpei, Zhang Xin, Bai Yin, Qiu Jiani, Wang Rui, Chen Yihan, Jin Qiaofeng, Zhang Li, Lv Qing, Xie Mingxing, Wu Wenqian.  (2025)  Ultrasound molecular imaging of M2 macrophages for early detection of chronic rejection in heart transplantation.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (1-17).  [PMID:40847355] [10.1186/s12951-025-03672-9]

15. Xiuqin Chen, Liangmiao Qiu, Qiquan Liu, Yuxian He.  (2025)  Development of a Dual-Shelled pH-Responsive Polymer-MOF Nanocarrier for Sustained Imidacloprid Delivery and Enhanced Control of Megoura crassicauda.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2025.137410]

16. Yong Li, Yuanyuan Zhou, Lifang Wu, Quanyuan Gao, Wei Wang.  (2025)  Cationic PPC liposomes with dual targeting modules through extracellular matrix barrier for enhanced liver fibrosis therapy.  Biomaterials Science,      [PMID:41160406] [10.1039/D5BM01262G]

17. Yuejun Jiang, Yicheng Ye, Hong Wang, Yunshi Li, Yalin He, Hui Ran, Xiurong Li, Cong Xu, Weilin Lu, Hao Tian, Yingfeng Tu, Yingjia Li.  (2025)  Engineered Probiotics Remodel the Tumor Immune Microenvironment.  ACS Nano,      [PMID:41208228] [10.1021/acsnano.5c13557]

18. Hao Shen, Tong Li, Xueying Chen, Zhurun Fang, Yan Xu, Kai Zheng, Ming Zhang.  (2025)  Multifunctional collagen hydrogel accelerates infected wound repair through photothermal disinfection and pro-angiogenic activity.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:41418368] [10.1016/j.colsurfb.2025.115382]

19. Ganxiang Yu, Huimin Deng, Chun Xu, Zhilan Huang, Yuanyuan Zhang, Cheng Luo, Lisha Chen, Huixin Chen.  (2025)  Targeted delivery of empagliflozin via glycyrrhetinic-acid-modified lipid nanoparticles for metabolic dysfunction–associated steatotic liver disease therapy.  MATERIALS & DESIGN,      [PMID:] [10.1016/j.matdes.2025.115391]

20. Cheng Fu, Tianyi Hu, Xiangli Zhao, Man Zhang, Tianhui Pan, Yahui Huang, Jiang Zhang, Lan Zhu, Gang Chen.  (2026)  Kidney Targeting Liposomes Loaded with the Antioxidant Pinocembrin for Treatment of Acute Kidney Injury.  ACS Applied Materials & Interfaces,      [PMID:41510988] [10.1021/acsami.5c18109]

21. Xuhui Fan, Ruru Zhang, Linjun Yang, Shixiong Chen, Meijuan He, Yongqiang Wang, Linjie Huang, Jianfeng Zeng, Shuwang Wu, Mingyuan Gao, Han Wang.  (2026)  CRISPR-Cas9-Loaded Theranostic Liposomes for Enhancing Radiosensitization of Prostate Cancer through POLD4 Gene Editing under Real-Time MRI Monitoring.  Advanced Science,      [PMID:41498761] [10.1002/advs.202519704]

22. Wenjing Li, Bi Lin, Bixiao Li, Peifu Zhang, Ziyue Ju, Anees A. Ansari, Ruichan Lv.  (2026)  Deep learning enabled magnetic/rare earth hybrid nanorobots for multi-modal bioimaging and temperature sensing with surgical boundary determination.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2026.139673]

23. Ji Luo, Feiying Yin, Yuan Liang, Yuting Ye, Shihui Xiao, Jianfeng Guo, Jianhui Xiang, Guanhua Li, Xin Yang, Jiejia Deng, Junxu Yang, Zhengtian Li, Jinmin Zhao, Li Zheng, Kelong Fan, Jingping Zhong.  (2026)  Engineering Asymmetric and Highly Exposed Fe Single-Atom Nanozymes for siMMP13 Delivery and Ferroptosis Inhibition in Osteoarthritis Therapy.  ADVANCED MATERIALS,      [PMID:41705627] [10.1002/adma.202520951]

24. Li Wang, Jiaqi Chen, Simin Gou, Yuting Long, Dandan Yang, Jifang Zhou, Yaxin Zheng, Wan Yan, Xuzhi Hu.  (2026)  A minimally invasive shape-programmable scaffold system for defect conformation and sustained paclitaxel delivery after osteosarcoma resection.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2026.140289]