5-Fluoro-2′-deoxyuridine(FUDR) - Moligand™, 10mM in DMSO , Thymidylate synthase inhibitor, CAS No.50-91-9, Thymidylate synthase inhibitor

CAS: 50-91-9 Cat. No.: F408736 Molecular Weight: 246.19 EC Number: 200-072-5

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Deoxyfluorouridine, FUDR | 5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Floxuridine (NSC 27640) Floxuridine (NSC 27640, Deoxyfluorouridine, FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(A
In vitro

Floxuridine exhibits higher affinity for PEPT1 than the corresponding 5\'-O-mono amino acid ester prodrugs. Floxuridine combined with Leucovorin results in synergistic inhibitory effects on growth of human T-lymphoblast leukemia cells. Floxuridine significantly inhibits the uptake of both [(3)H]-inosine and [(3)H]-adenosine (60-70% of control), while its amino acid ester prodrugs including Val, Phe, Pro, Asp, and Lys esters exhibits markedly decreased inhibition potency (10-30% of control). Floxuridine inhibits cell proliferation by more than 50% relative to the untreated control cells at 36 days, the cell numbers still increases fourfold compared with the initial cell density. Floxuridine results in prolonged effects on the proliferation of human Tenon\'s capsule fibroblasts in vitro. Floxuridine (FUDR) is an ideal drug for hepatic arterial infusion (HAI) due to its short half life, steep dose response curve, high total body clearance, and high hepatic extraction.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Deoxyfluorouridine, FUDR | 5-fluoro-1-((2R, 4S, 5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidine-2, 4(1H, 3H)-dione

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Floxuridine (NSC 27640, Deoxyfluorouridine, FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Thymidylate synthase inhibitor

Product Properties

• ALogP: -1.2

Names and Identifiers

• Isomeric SMILES: C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)F)CO)O
• RTECS: YU7525000
• UN Number: 1760
• Packing Group: I
• Molecular Weight: 246.19
• Reaxy-Rn: 24714617
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24714617&ln=

Chemical and Physical Properties

• Specific Rotation[α]: 38 ° (C=1, H2O)
• Melt Point(°C): 148°C

References

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