Cholelithiasis (cholelithiasis) is a common gastrointestinal disease that occurs in the gallbladder and bile ducts and has a high incidence. Cholelithiasis is the result of a combination of factors, with high morbidity and postoperative recurrence rate, which seriously affects people's life and health. Therefore, it is very necessary to establish a reasonable animal model applied to the study of cholelithiasis. Although the research on cholelithiasis has made great progress in recent years with the development of medicine, the clinical research on the treatment of cholelithiasis is facing great difficulties, and the establishment of animal models of cholelithiasis (animal models of cholelithiasis) provides a new way for the clinical research of cholelithiasis and the study of drugs. Currently, there are two main methods for modeling animal models of cholelithiasis: food induction method and foreign body implantation method.
Principle
The basic principles of cholelithiasis animal modeling experiments are
1. Biliary infections Bacterial infections can cause inflammation in the gallbladder or bile ducts of animals, and the exudate in the exfoliated epithelium, mucus, and bacterial colonies act as the core of the gallstone formation, and the protein components in the exudate can act as the important contributing factors to the nucleation, which is conducive to the deposition of cholesterol, bilirubin, bile salts, and the gradual formation of stones.
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