Fluorouracil (5-Fluorouracil, 5-FU) - Moligand™, 10mM in DMSO , RNA inhibitor, CAS No.51-21-8, RNA inhibitor

CAS: 51-21-8 Cat. No.: F408985 Molecular Weight: 130.08 Beilstein Registry Number: 127172 EC Number: 200-085-6
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GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
Synonyms
NSC 19893 | 5-​fluoro-2,​4(1H,​3H)​-​pyrimidinedione
Storage
Store at -80°C
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1ml
F408985-1ml
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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 239 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

Fluorouracil (5-Fluorouracil, 5-FU) Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be
In vitro

Adrucil is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen. It rapidly enters the cell using the same facilitated transport mechanism as uracil. Adrucil is converted intracellularly to several active metabolites: fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine triphosphate (FUTP). The Adrucil metabolite FdUMP binds to the nucleotide-binding site of TS, forming a stable ternary complex with the enzyme and CH2THF, thereby blocking binding of the normal substrate dUMP and inhibiting dTMP synthesis. Metabolite of Adrucil also can be misincorporated into DNA, leading to DNA strand breaks and cell death. The pro-apoptosis effects of Adrucil may be related to its activation of tumor suppressor p53. Loss of p53 function reduces cellular sensitivity to Adrucil. Adrucil is able to inhibit the survival and induce apoptosis of a board range of cancer cells. Adrucil suppresses viabilities of the nasopharyngeal carcinoma cell line CNE2 and HONE1 , pancreatic cancer cell lines Capan-1 , and human colon carcinoma cell line HT-29 with IC50 of 9 μg/mL, 3 μg/mL, 0.22 μM, 2.5 μM, respectively.

In vivo

Adrucil is widely used in the treatment of a range of cancers, including colorectal and breast cancers. 100mg/kg Adrucil significantly suppresses tumor growth of murine colon carcinomas Colon 38 with tumor-doubling time (TD), growth-delay factor (GDF), and T/C of 26.5 days, 4.4, and 14%.
Cell Data

cell lines:

Concentrations:~25 μM

Incubation Time:7 days

Powder Purity:≥99%

Specifications

Synonyms
NSC 19893 | 5-​fluoro-2, ​4(1H, ​3H)​-​pyrimidinedione
Specifications & Purity
Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms
Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
RNA inhibitor
Names and Identifiers
Isomeric SMILES C1=C(C(=O)NC(=O)N1)F
WGK Germany 3
RTECS YR0350000
Molecular Weight 130.08
Beilstein 127172
Reaxy-Rn 127172
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=127172&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
Boil Point(°C)190 - 200 °C / 374 - 392 °F@ 0.1 mmHg
Melt Point(°C)278 - 282 °C / 532.4 - 539.6 °F
Documents & Articles
Citations of This Product
References
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14. Yu-Ting Wang, Hong-Yu Tan, Xue Zhao, Yu Yang, Rui Xu, Shuai-Ming Zhu, Hao Ma, Fu-Yao Luo, Cai-Hong Dong, Chang-Wei Li.  (2023)  Sesquiterpenoid derivatives isolated from a liquid culture of Hypholoma capnoides 819.  PHYTOCHEMISTRY,      [PMID:38159621] [10.1016/j.phytochem.2023.113959]
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18. Yudi Ma, Xiaohui Lai, Zhongling Wen, Ziling Zhou, Minkai Yang, Qingqing Chen, Xuan Wang, Feng Mei, Liu Yang, Tongming Yin, Shucun Sun, Guihua Lu, Jinliang Qi, Hongyan Lin, Hongwei Han, Yonghua Yang.  (2023)  Design, synthesis and biological evaluation of novel modified dual-target shikonin derivatives for colorectal cancer treatment.  BIOORGANIC CHEMISTRY,      [PMID:37399615] [10.1016/j.bioorg.2023.106703]
19. Zhou Zhu, Jian Wang, Xibo Pei, Junyu Chen, Xinwei Wei, Yanhua Liu, Pengcheng Xia, Qianbing Wan, Zhen Gu, Yong He.  (2023)  Blue-ringed octopus-inspired microneedle patch for robust tissue surface adhesion and active injection drug delivery.  Science Advances,  (25):   [PMID:37343097] [10.1126/sciadv.adh2213]
20. Ningyue Liu, Siwei Zou, Conghua Xie, Yan Meng, Xiaojuan Xu.  (2023)  Effect of the β-glucan from Lentinus edodes on colitis-associated colorectal cancer and gut microbiota.  CARBOHYDRATE POLYMERS,      [PMID:37321711] [10.1016/j.carbpol.2023.121069]
21. Xubao Jiang, Suisui Wang, Xiang Zheng Kong.  (2023)  Quenching mechanism of PEG emission by pyrimidines and their detections using PEG as fluorescent sensor.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.143617]
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23. Jiawen Han, Yaru Ding, Xujuan Lv, Yuwei Zhang, Daoqing Fan.  (2023)  Integration of G-Quadruplex and Pyrene as a Simple and Efficient Ratiometric Fluorescent Platform That Programmed by Contrary Logic Pair for Highly Sensitive and Selective Coralyne (COR) Detection.  Biosensors-Basel,  13  (4): (489).  [PMID:37185564] [10.3390/bios13040489]
24. Dong-mei Li, Fu-cui Zhu, Jie Wei, Jia-xiu Xie, Jun-hui He, Dong-mei Wei, Yi Li, Ke-dao Lai, Li-min Liu, Qi-biao Su, Gui-ning Wei, Bin Wang, Yan-cheng Liu.  (2023)  The Active Fraction of Polyrhachis vicina Roger (AFPR) activates ERK to cause necroptosis in colorectal cancer.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:37059246] [10.1016/j.jep.2023.116454]
25. Zhen Yu, Shixin Chan, Xu Wang, Rui Sun, Ming Wang, Zhenglin Wang, Xiaomin Zuo, Jiajie Chen, Huabing Zhang, Wei Chen.  (2023)  5-Fluorouracil Combined with Rutaecarpine Synergistically Suppresses the Growth of Colon Cancer Cells by Inhibiting STAT3.  Drug Design Development and Therapy,      [PMID:37020802] [10.2147/DDDT.S402824]
26. Shangyun Lu, Jiali Xu, Yang Xu, Yang Liu, Dongxing Shi, Jia Wang, Fubin Qiu.  (2023)  Glycyrol attenuates colon injury via promotion of SQSTM1/p62 ubiquitination and autophagy by inhibiting the ubiquitin-specific protease USP8.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2023.105492]
27. Onyinyechi Lydia Ugorji, Olisa Ivy Okoye, Chinekwu Nwangwu, Chinazom Precious Agbo, Franklin Chimaobi Kenechukwu.  (2023)  Soluplus-stabilized 5-fluorouracil-entrapped niosomal formulations prepared via active and passive loading techniques: comparative physico-chemical evaluation.  JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY,      [PMID:] [10.1080/01932691.2023.2186427]
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29. Min-Li Zhang, Yi-Min Li, Zi-Xuan Zhao, Xiang-Yuan Li, Zhao-Cui Sun, Guo-Xu Ma, Mei-Hua Yang, Xu-Dong Xu, Xiao-Feng Zhang, Hai-Feng Wu, Qiong-Yu Zou, Nelbon Giloi.  (2023)  Cycloartane triterpene glycosides from Actaea vaginata.  Phytochemistry Letters,      [PMID:] [10.1016/j.phytol.2023.02.006]
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32. Huiquan Yang, Wenbin Chen, Jun Ma, Jing Zhao, Dongdong Li, Yuyu Cao, Peidang Liu.  (2023)  Silver Nanotriangles and Chemotherapeutics Synergistically Induce Apoptosis in Glioma Cells via a ROS-Dependent Mitochondrial Pathway.  International Journal of Nanomedicine,      [PMID:33116501] [10.2147/IJN.S267120]
33. Chaohong Gao, Yubing Wang, Heng Zhang, Wei Hang.  (2022)  Titania Nanosheet as a Matrix for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Analysis and Imaging.  ANALYTICAL CHEMISTRY,      [PMID:36577518] [10.1021/acs.analchem.2c01878]
34. Ren Jin, Liang Liang, Yang Yongqing, Liu Xiang, Li Weidong, Liu Wenbo, Wang Yali, Yu Jingmou.  (2022)  Assembling drug-loaded-layered double hydroxide nanohybrids with poloxamer 188 for improved cellular uptake and in vitro efficacy.  JOURNAL OF MATERIALS RESEARCH,  38  (2): (337-349).  [PMID:] [10.1557/s43578-022-00813-w]
35. Huanli Yin, Qi Yan, Yuan Liu, Lan Yang, Yang Liu, Yujie Luo, Tianyu Chen, Ningxi Li, Min Wu.  (2022)  Co-encapsulation of paclitaxel and 5-fluorouracil in folic acid-modified, lipid-encapsulated hollow mesoporous silica nanoparticles for synergistic breast cancer treatment.  RSC Advances,  12  (50): (32534-32551).  [PMID:36425719] [10.1039/D2RA03718A]
36. Yue-Ming Yu, Fan-Zhi Bu, Su-Su Meng, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li.  (2022)  The first marine dual-drug cocrystal of cytarabine with 5-fluorouracil having synergistic antitumor effects shows superior biopharmaceutical peculiarities by oral administration.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:36372139] [10.1016/j.ijpharm.2022.122386]
37. Liang Qin, Fenglan Liang, Yan Li, Jiana Wu, Shiyuan Guan, Meiyin Wu, Shiling Xie, Manshi Luo, Deyun Ma.  (2022)  A 2D Porous Zinc-Organic Framework Platform for Loading of 5-Fluorouracil.  Inorganics,  10  (11): (202).  [PMID:] [10.3390/inorganics10110202]
38. Yang Bingxue, Xie Xinran, Lv Dazhao, Hu Jiajun, Chen Yuyun, Wu Zhaoyu, Luo Shuyue, Zhang Shiyi.  (2022)  Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil.  BRITISH JOURNAL OF CANCER,  128  (2): (219-231).  [PMID:36347964] [10.1038/s41416-022-02039-3]
39. Zhang Shiyu, Mi Yinxiao, Ye Tingting, Lu Xiaoyan, Liu Li, Qian Jing, Fan Xiaohui.  (2022)  Carbohydrates and ginsenosides in shenmai injection jointly improve hematopoietic function during chemotherapy-induced myelosuppression in mice.  Chinese Medicine,  17  (1): (1-15).  [PMID:36333798] [10.1186/s13020-022-00678-5]
40. Wang Mi, Shen Yanting, Hu Xiaoxiao, Zhu Yanyan, Wang Jing.  (2022)  Colorimetric/SERS dual-channel nanoprobe for reactive oxygen species monitoring in elucidating the mechanism of chemotherapeutic drugs action on cancer cells.  MICROCHIMICA ACTA,  189  (9): (1-11).  [PMID:36008738] [10.1007/s00604-022-05451-x]
41. Yanyan Wang, Liuqian Bao, Jiajing Sun, Yuanyuan Ding, Jiasheng Shi, Zhengyu Duan, Zhiyong Chen.  (2022)  Superhydrophobic fluorinated microspheres for fluorous affinity chromatography.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:36001909] [10.1016/j.chroma.2022.463428]
42. Huixia Feng, Guilin Chen, Yongli Zhang, Mingquan Guo.  (2022)  Potential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2.  Journal of Inflammation Research,      [PMID:35996684] [10.2147/JIR.S371830]
43. Dongsheng Fu, Jinhui You, Ruijie Guo, Jie Zhang, Qiang Li, Jing Wen, Huifang Wang, Hong Yan.  (2022)  Preparation of Nanostructured Graphene Oxide and Its Application in Drug Loading and Sustained Release.  ChemistrySelect,  (30): (e202200670).  [PMID:] [10.1002/slct.202200670]
44. Tianyu Chen, Hui Chen, Yichun Jiang, Qi Yan, Shuling Zheng, Min Wu.  (2022)  Co-Delivery of 5-Fluorouracil and Paclitaxel in Mitochondria-Targeted KLA-Modified Liposomes to Improve Triple-Negative Breast Cancer Treatment.  Pharmaceuticals,  15  (7): (881).  [PMID:35890181] [10.3390/ph15070881]
45. Ya-Hui Yu, Li Wang, Qiang Zhang, Xiao-Nan Zhang, Xin-Huai Zhao.  (2022)  Activities of the soluble and non-digestible longan (Dimocarpus longan Lour.) polysaccharides against HCT-116 cells as affected by a chemical selenylation.  Current Research in Food Science,      [PMID:35799859] [10.1016/j.crfs.2022.06.008]
46. Xiaofei Liao, Mengyan Li, Li Zou.  (2022)  Target-induced activation of DNAzyme for highly sensitive colorimetric detection of bleomycin via DNA scission.  RSC Advances,  12  (29): (18296-18300).  [PMID:35799941] [10.1039/D2RA02816F]
47. Hanwen Liu, Ying Liu, Ting Zhou, Penghui Zhou, Jianguo Li, Anping Deng.  (2022)  Ultrasensitive and Specific Detection of Anticancer Drug 5-Fluorouracil in Blood Samples by a Surface-Enhanced Raman Scattering (SERS)-Based Lateral Flow Immunochromatographic Assay.  MOLECULES,  27  (13): (4019).  [PMID:35807264] [10.3390/molecules27134019]
48. Kun Fang, Sha Du, Dachuan Shen, Zhipeng Xiong, Ke Jiang, Dapeng Liang, Jianxin Wang, Huizhe Xu, Lulu Hu, Xingyue Zhai, Yuting Jiang, Zhiyu Xia, Chunrui Xie, Di Jin, Wei Cheng, Songshu Meng, Yifei Wang.  (2022)  SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway.  iScience,      [PMID:35800779] [10.1016/j.isci.2022.104618]
49. Yaowei Guo, Jin Liu, Qinglin Tang, Cuicui Li, Yanying Zhang, Yao Wang, Yanxin Wang, Yupeng Bi, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore, Jianguo Tang.  (2022)  Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  23  (12): (6597).  [PMID:35743042] [10.3390/ijms23126597]
50. Ting Zhou, Guangzhao He, Changjia Hu, Kang Wu, Ying Liu, Jianguo Li, Anping Deng.  (2022)  Development of a highly sensitive and specific monoclonal antibody-based ELISA coupled with immuno-affinity extraction for the detection of anticancer drug 5-fluorouracil in blood samples.  TALANTA,      [PMID:35696979] [10.1016/j.talanta.2022.123655]
51. Li Cheng, Fang Wang, Yuanxin Cao, Chaoying Tong, Qisheng Wei, Shuyun Shi, Ying Guo.  (2022)  Rapid profiling of potential antitumor polymethoxylated flavonoids in natural products by integrating cell biospecific extraction with neutral loss/diagnostic ion filtering-based high-performance liquid chromatography–quadrupole time-of-flight tandem mass spectrometry.  PHYTOCHEMICAL ANALYSIS,  33  (6): (895-905).  [PMID:35668040] [10.1002/pca.3147]
52. Hao Guo, Songjie Fan, Jianhua Liu, Yumei Wang.  (2022)  A dual-pH sensitive drug release system for combinatorial delivery of 5‑fluorouracil and leucovorin calcium in colon cancer therapy.  INORGANIC CHEMISTRY COMMUNICATIONS,      [PMID:] [10.1016/j.inoche.2022.109616]
53. Jieping Zhang, Shaomin Zou, Yijing Zhang, Ziqing Yang, Wencong Wang, Manqi Meng, Junyan Feng, Peng Zhang, Lishi Xiao, Mong-Hong Lee, Lekun Fang.  (2022)  3,3′-Diindolylmethane Enhances Fluorouracil Sensitivity via Inhibition of Pyrimidine Metabolism in Colorectal Cancer.  Metabolites,  12  (5): (410).  [PMID:35629914] [10.3390/metabo12050410]
54. Ya-Hui Yu, Zhi-Mei Tang, Cen Xiong, Fei-Fei Wu, Jun-Ren Zhao, Xin-Huai Zhao.  (2022)  Enhanced Growth Inhibition and Apoptosis Induction in Human Colon Carcinoma HT-29 Cells of Soluble Longan Polysaccharides with a Covalent Chemical Selenylation.  Nutrients,  14  (9): (1710).  [PMID:35565676] [10.3390/nu14091710]
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135. Li Da-Hong, Li Chen-Xi, Jia Cui-Cui, Sun Ya-Ting, Xue Chun-Mei, Bai Jiao, Hua Hui-Ming, Liu Xiao-Qiu, Li Zhan-Lin.  (2015)  Xanthones from Garcinia paucinervis with in vitro anti-proliferative activity against HL-60 cells.  ARCHIVES OF PHARMACAL RESEARCH,  39  (2): (172-177).  [PMID:26659874] [10.1007/s12272-015-0692-6]
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137. Xue-Jie Wang, Jin-zong You, Feng Yu.  (2015)  Study on the thermal decomposition of emtricitabine.  JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS,      [PMID:] [10.1016/j.jaap.2015.08.011]
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147. Chang-Jing Wu, Chang-Wei Li, Cheng-Bin Cui.  (2014)  Seven New and Two Known Lipopeptides as well as Five Known Polyketides: The Activated Production of Silent Metabolites in a Marine-Derived Fungus by Chemical Mutagenesis Strategy Using Diethyl Sulphate.  Marine Drugs,  12  (4): (1815-1838).  [PMID:24686557] [10.3390/md12041815]
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152. Huanshun Yin, Yunlei Zhou, Zhenning Xu, Mo Wang, Shiyun Ai.  (2013)  Ultrasensitive electrochemical immunoassay for DNA methyltransferase activity and inhibitor screening based on methyl binding domain protein of MeCP2 and enzymatic signal amplification.  BIOSENSORS & BIOELECTRONICS,      [PMID:23708816] [10.1016/j.bios.2013.04.040]
153. Hai-Yan Zhao, Li Yang, Jian Wei, Ming Huang, Jian-Guo Jiang.  (2012)  Bioactivity evaluations of ingredients extracted from the flowers of Citrus aurantium L. var. amara Engl.  FOOD CHEMISTRY,      [PMID:22980787] [10.1016/j.foodchem.2012.07.018]
154. Cheng Zhang, Guodong Li, Yihan Wang, Fuying Cui, Jien Zhang, Qingshan Huang.  (2012)  Preparation and characterization of 5-fluorouracil-loaded PLLA–PEG/PEG nanoparticles by a novel supercritical CO2 technique.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:22721846] [10.1016/j.ijpharm.2012.06.022]
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157. Jiang Xiaoqian, Qu Aihua, Xu Xinxin, Kuang Hua, Liu Liqiang, Xu Chuanlai.  (2024)  A gold-based multiplex immunochromatographic sensor for detecting paclitaxel, methotrexate, and 5-fluorouracil in clinical samples.  Nano Research,      [PMID:] [10.1007/s12274-024-6649-7]
158. Tao Wu, Jingqiu Zhou, Wanli He, Lei Jin, Tenghui Li, Tianxing Gong, Xu Liu.  (2025)  An injectable multimodal thiolated carboxymethyl cellulose hydrogel for advanced gastric cancer treatment.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40020807] [10.1016/j.ijbiomac.2025.141546]
159. Danping Liu, Li-Sheng Xie, Shitao Lian, Kexin Li, Yun Yang, Wen-Zhao Wang, Songnian Hu, Shuang-Jiang Liu, Chang Liu, Zilong He.  (2024)  Anaerostipes hadrus, a butyrate-producing bacterium capable of metabolizing 5-fluorouracil.  mSphere,      [PMID:38470044] [10.1128/msphere.00816-23]
160. Jiamei Song, Jiaqi Zeng, Xi Chen, Jiayu Wang, Ying Zhang, Yuhao Gao, Ruiqi Wang, Nan Jiang, Yuhui Lin, Rui Li.  (2025)  Anti-neuroinflammatory agent rhein lysinate-based self-assembled injectable hydrogel loaded with ZL006 for promoting post-stroke functional recovery.  BIOMATERIALS,      [PMID:39884131] [10.1016/j.biomaterials.2025.123124]
161. Chen Siwei, Huang Hongwu, Li Qi, Cai Jia, Miao Zhuolin, Xie Peikang, Tang Shengsong, He Dongxiu.  (2024)  Carrier-free nanoparticles based on self-assembly of 5-FU and copper-genistein complexes for the combined treatment of hepatocellular carcinoma.  Drug Delivery and Translational Research,      [PMID:39126575] [10.1007/s13346-024-01676-w]
162. Chengfei Yue, Changkun Ding, Min Hu, Ruquan Zhang, Bowen Cheng.  (2024)  Collagen/functionalized cellulose nanofibril composite aerogels with pH-responsive characteristics for drug delivery system.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38286379] [10.1016/j.ijbiomac.2024.129650]
163. Xiang Yu, Di Zhang, Chengming Hu, Zejun Yu, Yang Li, Cheng Fang, Yinsheng Qiu, Zhinan Mei, Lingyun Xu.  (2024)  Combination of Diosmetin With Chrysin Against Hepatocellular Carcinoma Through Inhibiting PI3K/AKT/mTOR/NF-кB Signaling Pathway: TCGA Analysis, Molecular Docking, Molecular Dynamics, In Vitro Experiment.  Chemical Biology & Drug Design,  104  (4): (e70003).  [PMID:39448547] [10.1111/cbdd.70003]
164. Qing Wang, Jiajia You, Yichen Li, Jie Zhang, Yi Wang, Meijuan Xu, Zhiming Rao.  (2024)  Continuous Evolution of Protein through T7 RNA Polymerase-Guided Base Editing in Corynebacterium glutamicum.  ACS Synthetic Biology,      [PMID:39700484] [10.1021/acssynbio.4c00606]
165. Yingzhen Guan, Michel Nguyen, Anne Robert, Yan Liu, Bernard Meunier.  (2024)  Copper selective 8-aminoquinoline based tetradentate chelators as anticancer agents.  RSC Medicinal Chemistry,      [PMID:39309357] [10.1039/D4MD00171K]
166. Xiaotian Guan, Jingru Zhao, Zhou Sha, Yujie Liang, Jianghong Huang, Jun Zhang, Shuqing Sun.  (2024)  CRISPR/Cas12a and aptamer-chemiluminescence based analysis for the relative abundance determination of tumor-related protein positive exosomes for breast cancer diagnosis.  BIOSENSORS & BIOELECTRONICS,      [PMID:38754193] [10.1016/j.bios.2024.116380]
167. Muchen Zhang, Huangwei Song, Siyuan Yang, Yan Zhang, Yunrui Tian, Yang Wang, Dejun Liu.  (2024)  Deciphering the Antibacterial Mechanisms of 5-Fluorouracil in Escherichia coli through Biochemical and Transcriptomic Analyses.  Antibiotics-Basel,  13  (6): (528).  [PMID:38927194] [10.3390/antibiotics13060528]
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169. Ya-Shuai Kang, Hao-Wen Zhu, Xue Zhao, Hao Ma, Yu Yang, Rui Xu, Fu-Yao Luo, Er-Wei Li, Qian Luo, You-Zhi Zhang, Chang-Wei Li.  (2025)  Diversity of Endophytic Fungi Isolated From Huperzia serrata and Research on the Secondary Metabolites of Penicillium panissanguineum SZSS 4-2-2.  CHEMISTRY & BIODIVERSITY,      [PMID:40098595] [10.1002/cbdv.202500701]
170. Yukun Zhong, Haining Li, Teng Jiang, Xueliang Mu, Munetoshi Seki, U Kei Cheang.  (2024)  Double-Layered Metal-Organic-Frameworks-Based Microswimmers for Adaptive Dual-Drug Anti-Cancer Therapy Using Artemisinin-Based Compounds.  Advanced Intelligent Systems,      [PMID:] [10.1002/aisy.202400244]
171. Yue-Ming Yu, Xue-Jie Li, Fan-Zhi Bu, Zhi-Long Zhao, Zhi-Yong Wu, Yan-Tuan Li.  (2024)  Drug–Drug Cocrystal Alloy and Nanoformulation of Cytarabine: Optimized Biopharmaceutical Property and Synergistic Antitumor Efficacy.  MOLECULAR PHARMACEUTICS,      [PMID:39392428] [10.1021/acs.molpharmaceut.4c00733]
172. Yaxue Xie, Pingxiong Cai, Huining Xiao, Yuanfeng Pan.  (2024)  Dual-responsive, highly bacteriostatic and swellable chitosan-based hydrogels loaded with 5-fluorouracil for sustainable release.  REACTIVE & FUNCTIONAL POLYMERS,      [PMID:] [10.1016/j.reactfunctpolym.2024.105992]
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174. Onyinyechi Lydia Ugorji, Ikechukwu Virgilius Onyishi, Amarauche Chukwu, Anthony Amaechi Attama.  (2024)  Engineering 5-flourouracil and leucovorin-loaded vesicular systems for possible colon specific delivery: In vitro evaluation and real time cell assay against HCT-116 colon cell lines.  Heliyon,      [PMID:38655322] [10.1016/j.heliyon.2024.e28872]
175. Qing Sun, Jiao Yan, Xiaofang Hu, Jiale Yu, Jian Zhang, Jiawei Sheng.  (2024)  Facile coating Co/Ca-silicate on 13X for enhanced degradation of metronidazole via peroxymonosulfate activation: Catalytic performance and toxicity evolution.  MICROPOROUS AND MESOPOROUS MATERIALS,      [PMID:] [10.1016/j.micromeso.2024.113424]
176. Yu-Ting Wang, Yuan Dong, Fang Wang, Shuai-Ming Zhu, Yang Zhang, Yu Yang, Rui Xu, Cai-Hong Dong, You-Zhi Zhang, Chang-Wei Li.  (2024)  Four New Caryophyllene Sesquiterpenoids Isolated From Hypholoma capnoides 819.  CHEMISTRY & BIODIVERSITY,      [PMID:39614646] [10.1002/cbdv.202402414]
177. Xiaobo Cai, Min Cao, Qingliang Yang, Xiazhen Yu, Xin-Hua Feng, Robert Yongxin Zhao.  (2024)  HER2-targeted ADC DX126-262 combined with chemotherapy demonstrates superior antitumor efficacy in HER2-positive gastric cancer.  American Journal of Cancer Research,  14  (12): (5752).  [PMID:39803638] [10.62347/QCDR9612]
178. Qiaomei Ke, Ke Jiang, Hong Li, Ling Zhang, Banglin Chen.  (2024)  Hierarchically Micro-, Meso-, and Macro-Porous MOF Nanosystems for Localized Cross-Scale Dual-Biomolecule Loading and Guest-Carrier Cooperative Anticancer Therapy.  ACS Nano,      [PMID:39102565] [10.1021/acsnano.4c02288]
179. Xiangxiang Zhang, Chao Li, Shubin Li, Xuefeng Tang, Jingjing Zhao, Weili Xu, Xiaojun Han.  (2025)  High-Throughput Programmable Tumor Spheroid Generation Using the Magneto-Archimedes Effect.  ACS Applied Materials & Interfaces,      [PMID:40022287] [10.1021/acsami.4c21198]
180. Min Yu, Jian-Qin Yan, Ling-Yang Wang, Zhi-Yong Wu, Meng-Yao Wu, Yong Sun, Yan-Tuan Li.  (2024)  Integrating Theory with Experimental Studies on the Directed Assembly of Phenforminium 5-Fluorouracilate toward Enhanced In Vitro/Vivo Properties and Synergistic Antitumor Efficacy.  CRYSTAL GROWTH & DESIGN,      [PMID:] [10.1021/acs.cgd.4c00295]
181. Liqin Xie, Xirui Zuo, Beilei Wang, Dan Li, Wenke Chang, Shenglu Ji, Dan Ding.  (2024)  Micelle-like Nanoparticles for Drug Delivery and Magnetically Enhanced Tumor Chemotherapy.  ACS Biomaterials Science & Engineering,      [PMID:39576943] [10.1021/acsbiomaterials.4c01897]
182. Zhiqiang Zhang, Chenxi Fang, Junfang Ke, Yue Li, Meitao Duan, Jungang Ren, Chen Wang.  (2025)  Microneedle drug delivery system based on hyaluronic acid for improving therapeutic efficiency of hypertrophic scars.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39805460] [10.1016/j.ijbiomac.2025.139790]
183. Guangchao Xie, Bingjie Li, Shuyue Guo, Wenjing Hou, Yao Wang, Jiamei Liu, Jialin Zhu, Luchen Chang, Xiaoqing Wang, Xiaoyi Wang, Jinbin Pan, Xi Wei.  (2025)  Minimalistic Implant for Percutaneous Magnetic Hyperthermia-Based Combination Therapy of Hepatocellular Carcinoma.  ACS Applied Materials & Interfaces,      [PMID:39916295] [10.1021/acsami.4c18486]
184. Chunxia Qi, Ang Li, Baoming Wu, Peisan Wang.  (2024)  Multi-Sensitive Au NCs/5-FU@Carr-LA Composite Hydrogels for Targeted Multimodal Anti-Tumor Therapy.  MOLECULES,  29  (17): (4051).  [PMID:39274898] [10.3390/molecules29174051]
185. Lengshan Mo, Cansheng Hong, Zhihan Jiang, Yiqiang Zhu, Lu Zhou, Simin Tan, Guorong Deng, Yanwei Qi, Tengfei Hu, Qianlian Wu, Yi Zhao, Huaina Qiu, Taizhen Liang, Peibin Lin, Jian Zhang, Xiancai Ma, Quan Yang.  (2024)  Myeloid-derived suppressor cells inhibit responses of T follicular helper cells during experimental Plasmodium yoelii infection.  FASEB JOURNAL,  38  (23): (e70211).  [PMID:39629706] [10.1096/fj.202401237R]
186. Li Yang, Liu Xiaoyan, Liu Zhongming, Wang Shoujuan, Kong Fangong.  (2024)  Nanocellulose composite aerogels for efficient drug loading and sustained release.  CELLULOSE,  31  (14): (8539-8554).  [PMID:] [10.1007/s10570-024-06061-x]
187. Zhongyi Guo, Kang Fu, Jingyi Sun, Wenhao Du, Qisheng Hao, Xiao Hu.  (2024)  Near-infrared-responsive Prussian blue nanocages loaded with 5-fluorouracil for combined chemotherapy and photothermal therapy in tumor treatment.  RSC Advances,  14  (34): (24942-24951).  [PMID:39131498] [10.1039/D4RA04609A]
188. Xinqi Qiu, Minhui Zhang, Yan Liu, Mingao Li, Quanzhou Wu, Jianfeng He.  (2024)  Novel water-compatible surface molecularly imprinted polymer microspheres based on boronate affinity and hydrophilic coating for efficient enrichment and separation of capecitabine from urine samples.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.111289]
189. Guangchao Xie, Bingjie Li, Xuejun Zhang, Jiaojiao Yu, Shao-Kai Sun.  (2024)  One-Minute Preparation of Iron Foam-Drug Implant for Ultralow-Power Magnetic Hyperthermia-Based Combination Therapy of Tumors in Vivo.  Advanced Science,  11  (11): (2307823).  [PMID:38164827] [10.1002/advs.202307823]
190. Yue Lu, Ming-Hua Duan, Xue Zhao, Yang Zhang, Yu Yang, Rui Xu, Ya-shuai Kang, Zi-Lin Wang, You-Zhi Zhang, Chang-Wei Li.  (2024)  Pestiorosins A–F, New Papulacandins Isolated from the Fungus Pestalotiopsis rosea YNJ21.  CHEMISTRY & BIODIVERSITY,      [PMID:39246262] [10.1002/cbdv.202401921]
191. Zhu Yiqiang, Zhou Lu, Mo Lengshan, Hong Cansheng, Pan Lingxia, Lin Jie, Qi Yanwei, Tan Simin, Qian Manhongtian, Hu Tengfei, Zhao Yi, Qiu Huaina, Lin Peibin, Ma Xiancai, Yang Quan.  (2024)  Plasmodium yoelii Infection Enhances the Expansion of Myeloid-Derived Suppressor Cells via JAK/STAT3 Pathway.  JOURNAL OF IMMUNOLOGY,      [PMID:38819229] [10.4049/jimmunol.2300541]
192. Fan Yang, Jing Zhao, Zhengang Wu, Yingna Wei, Hengyong Wei, Jingwu Li, Bo Li.  (2024)  Preparation and characterization of 5-fluorouracil drug cocrystal and its dynamic monitoring of cocrystallization process via SERS spectroscopy.  VIBRATIONAL SPECTROSCOPY,      [PMID:] [10.1016/j.vibspec.2024.103749]
193. Ya-Hui Yu, Kouadio Jean Eric-Parfait Kouame, Xiaozhen Liu, Xiangying Yu, Ming-Yu Jin, Long-Qing Li, Fengyuan Liu, Yuting Li, Jing-Kun Yan, Bing Li.  (2025)  Preparation, characterization, and induced human colon cancer HCT-116 and HT-29 cell apoptosis performance of selenium nanoparticles stabilized by longan polysaccharides.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39920945] [10.1016/j.ijbiomac.2025.140719]
194. Xiaoxiang Gao, Yinghui Qiu, Wei Liao, Chao Zhao.  (2024)  Protocol for screening potential targets for the treatment of hepatocellular carcinoma based on H22 tumor-bearing mouse model.  STAR Protocols,      [PMID:39423126] [10.1016/j.xpro.2024.103193]
195. Jinmiao Tian, Lichao Zhang, Xiaoqin La, Yuxuan An, Xiaxia Fan, Zhuoyu Li.  (2024)  QPH-FR: A Novel Quinoa Peptide Enhances Chemosensitivity by Targeting Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5 in Colorectal Cancer.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:39047262] [10.1021/acs.jafc.4c03761]
196. Ruige Yang, Xiangjing Fu, Jiangping Fan, Tingting Wang, Jian Song, Ting Xu, Yong Guo, Sai-Yang Zhang.  (2024)  Semisynthesis and biological evaluation of novel honokiol thioethers against colon cancer cells HCT116 via inhibiting the transcription and expression of YAP protein.  BIOORGANIC & MEDICINAL CHEMISTRY,      [PMID:38759254] [10.1016/j.bmc.2024.117762]
197. Simei Liu, Tingting Zhang, Zilong Chen, Ke Guo, Peng Zhao.  (2025)  Structural characterization of Corydalis yanhusuo polysaccharides and its bioactivity in vitro.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40023428] [10.1016/j.ijbiomac.2025.141575]
198. Long Deng, Junqiu Liao, Weiqi Liu, Shiyuan Liu, Xiaoxiao Liang, Rujin Zhou, Yanbin Jiang.  (2025)  Study of Zn2+ complexation driven zein-based W/O/W Pickering emulsions for enhancing curcumin bioaccessibility and fluorouracil bioactivity.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2025.111243]
199. Xiaoxiao Liang, Yanru Wu, Yuehua Deng, Xingye Zeng, Shufeng Shan, Yanbin Jiang, Huaiyu Yang.  (2024)  Supramolecular self-assembly strategy for the enhanced solubility/dissolution rate and anti-cancer efficacy of osimertinib: Insights from multi-component crystals to drug chemistry.  CHEMICAL ENGINEERING SCIENCE,      [PMID:] [10.1016/j.ces.2024.120520]
200. Jun Gao, Miaomiao Li, Haiying Chen, Ze Xu, Junyao Li, Yong Kong, Xiaoming Zuo.  (2024)  Synthesis of stimuli-responsive copolymeric hydrogels for temperature, reduction and pH-controlled drug delivery.  JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY,      [PMID:] [10.1016/j.jiec.2024.08.027]
201. Nannan Kang ,Jun Ma ,Yuling Hu ,Rongrong Di ,Lei Wang ,Xuanling Zhang ,Yisheng Lai , Yu Liu .  (2024)  Targeting MutT Homolog 1 (MTH1) for Breast Cancer Suppression by Using a Novel MTH1 Inhibitor MA−24 with Tumor-Selective Toxicity.  Pharmaceuticals,  17  (3): (291).  [PMID:38543077] [10.3390/ph17030291]
202. Jing Zuo, Yingying Quan, Yue Li, Dong Song, Jinpeng Li, Yuxin Wang, Li Yi, Yang Wang.  (2024)  Targeting ThyA: Investigating the mechanisms of 5-FU-induced inhibition of biofilm formation and virulence in Streptococcus suis through LuxS/AI-2 quorum sensing1.  Journal of Integrative Agriculture,      [PMID:] [10.1016/j.jia.2024.07.007]
203. Mangmang Feng, Xiaxia Fan, Jiangying Shi, Shuhua Shan, Songtao Li, Shuiling He, Man Ding, Zhuoyu Li.  (2024)  Terpenoids from quinoa reverse drug resistance of colon cancer by upregulating miR-495-3p.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,      [PMID:38962946] [10.1002/jsfa.13718]
204. Xiao-liang Zhao, Zheng-lei Guo, Kai-li Qi, Qing-song Zhou, Yan-mei Liu, Li-xia Xiong, Jing Zhang, Ji Zhang, Wei-jie Zhang.  (2024)  The Polysaccharides from Pinellia ternata and Their Derivatives: Preparation, Structure Characteristics, and Activities in Vitro.  CHEMISTRY & BIODIVERSITY,  21  (8): (e202400596).  [PMID:38804585] [10.1002/cbdv.202400596]
205. Haihua Zhou, Hongyan Pan, Faisal Raza, Hajra Zafar, Yu Ge, Nan Wang, Ronglei Zheng, Degeng Zhang, Yanmin Yang.  (2024)  Thermosensitive drug-loaded liposomes for photothermal and chemotherapeutic treatment of colon cancer.  Materials Advances,  (6): (2456-2469).  [PMID:] [10.1039/D3MA01060K]
206. Zhang Lisheng, Huang Yan, Yang Yanting, Liao Birong, Hou Congyan, Wang Yiqi, Qin Huaiyu, Zeng Huixiang, He Yanli, Gu Jiangyong, Zhang Ren.  (2024)  TIMM9 as a prognostic biomarker in multiple cancers and its associated biological processes.  Scientific Reports,  14  (1): (1-21).  [PMID:39232081] [10.1038/s41598-024-71421-3]
207. Lihong Chen, Zijia Zhao, Rominah Onintsoa Diarimalala, Zhongwei Chen, Yu Wang, Taozhu Zhan, Yanchao Zhao, Chunhui Ma, Xingyue Wang, Chenqi Zhao, Zicheng Xiao, Kanghong Hu, Pingfan Wu.  (2024)  Tris-functionalized polyoxotungstovanadate-mediated antitumor efficacy involves multiple cell death pathways.  CHEMISTRY & BIODIVERSITY,      [PMID:38369765] [10.1002/cbdv.202301898]
208. Jia Liu, Zhiyang Wang, Xiaowei Wu, Shanyue Wei, Yiming Xie, Jing Chen, Can-Zhong Lu.  (2024)  Two-dimensional covalent organic framework-based hybrid nanosheets for electrochemical detection of 5-fluorouracil and uracil in biofluids.  Materials Chemistry Frontiers,      [PMID:] [10.1039/D4QM00439F]
209. Zhao Kai, Yan Yu, Jin Xiao-Kang, Pan Ting, Zhang Shi-Man, Yang Chi-Hui, Rao Zhi-Yong, Zhang Xian-Zheng.  (2025)  An orally administered gene editing nanoparticle boosts chemo-immunotherapy in colorectal cancer.  Nature Nanotechnology,      [PMID:40269250] [10.1038/s41565-025-01904-5]
210. Junzhe Fu, Weijiang Yu, Yixian Mu, Xuedan Qian, Xinyi Li, Ke Sun, Youxiang Wang, Jian Ji.  (2025)  Hypoxia Alleviation Enhances the Efficacy of 5-Fluorouracil in Hypertrophic Scar Therapy via an Oxygen-Popping Microneedle System.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202422678]
211. Shuai Zhou, Chendi Ding, Cheng Wang, Jiajun Fu.  (2019)  UV-light cross-linked and pH de-cross-linked coumarin-decorated cationic copolymer grafted mesoporous silica nanoparticles for drug and gene co-delivery in vitro.  Materials Science & Engineering C-Materials for Biological Applications,      [PMID:31923958] [10.1016/j.msec.2019.110469]
212. Shan-Mei Chen, Jun-Nan Feng, Chuan-Ke Zhao, Li-Cheng Yao, Li-Xin Wang, Lin Meng, Shao-Qing Cai, Cai-Yun Liu, Li-Ke Qu, Yan-Xing Jia, Cheng-Chao Shou.  (2022)  A multi-targeting natural product, aiphanol, inhibits tumor growth and metastasis.  American Journal of Cancer Research,      [PMID:36504899] [PMID:36504899]
213. Xia Tian, Meng Liu, Xiaodong Huang, Qingxi Zhu, Weijie Liu, Wei Chen, Yanli Zou, Yishan Cai, Shasha Huang, Aifang Chen, Ting Zhan, Min Huang, Xiaoli Chen, Zheng Han, Jie Tan.  (2020)  Noscapine Induces Apoptosis in Human Colon Cancer Cells by Regulating Mitochondrial Damage and Warburg Effect via PTEN/PI3K/mTOR Signaling Pathway.  OncoTargets and Therapy,      [PMID:32606759] [10.2147/OTT.S232137]
214. Qing Sun, Jiao Yan, Jiale Yu, Xiaofang Hu, Jian Zhang, Jiawei Sheng.  (2025)  Designing Mg-enhanced cobalt silicate @13X core-shell nanostructures via in-situ growth: synergistic PMS activation and anti-leaching for efficient metronidazole mineralization.  NANOTECHNOLOGY,  36  (19): (195602).  [PMID:40164101] [10.1088/1361-6528/adc741]
215. Xiaoliang Zhao, Qingsong Zhou, He Mou, Li Ma, Yanmei Liu, Kaili Qi, Cunjin Wang, Jing Zhang, Ji Zhang, Weijie Zhang.  (2025)  Sulfated modification of polysaccharides from Sophora flavescens: Impact on antioxidant, antitumor, and immunomodulatory activities.  FITOTERAPIA,      [PMID:40258430] [10.1016/j.fitote.2025.106560]
216. Yang Chen, Cai Peng.  (2025)  Unveiling the Oral Therapeutic Promise of 5-Fluorouracil-Laden Thiol-Chitosan-Coated Metal-Organic Frameworks.  Journal of Inorganic and Organometallic Polymers and Materials,      [PMID:] [10.1007/s10904-025-03796-3]
217. Wang Ying, Yang YunXia, Zhu Daliang, Zhang Hongmei, Wang Yanqing.  (2025)  Preparation, characterization, and anticancer activity evaluation of Ganoderma lucidum polysaccharide/5-fluorouracil conjugate.  COLLOID AND POLYMER SCIENCE,      [PMID:] [10.1007/s00396-025-05414-7]
218. Jingqiu Zhou, Zaishan Zhang, Zhili Zhang, Tao Wu, Hao Li, Xujia Hao, Xu Liu, Tianxing Gong, Dan Liu, Shibo Wei.  (2025)  A facile dual-drug delivery system using cellulose-based microgel/hydrogel for enhanced gastric cancer therapy.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:40412286] [10.1016/j.colsurfb.2025.114813]
219. Zhao Yi, Dai Zhengqun, Lang Yanmei, Li Rui, Zheng Hongyu, Mi Jiajia, He Xiu, Liu Jin, Xiang Rong, Mei Xueran, Liu Yang, Wang Yantang, Guo Huijie, Yang Qian, Ren Ke, Yang Tai.  (2025)  Screening of Fecal Bacteroides Strains and Discovery of Bacteroides eggerthii S13-F8 with Protective Effects Against Chemotherapy-Induced Diarrhea.  Probiotics and Antimicrobial Proteins,      [PMID:40423879] [10.1007/s12602-025-10595-2]
220. Xiaoliang Zhao, Yanmei Liu, Haili Wang, Kaili Qi, Haidong Wen, Yuxin Wang, Yuanyuan Ma, Cunjin Wang, Jing Zhang, Yonggang Wang, Weijie Zhang.  (2025)  Preparation, Structure Characteristics, Antioxidant, Antitumor, and Immunomodulatory Activity of Polysaccharides From Rheum officinale Baill. and Their Derivatives.  CHEMISTRY & BIODIVERSITY,      [PMID:40387065] [10.1002/cbdv.202500732]
221. Aijing Jia, Yucong Xu, Chaonan Sun, Hongwei Luan, Zhiteng Liu, Ying Bu, Wenhui Zhu, Xuepeng Li.  (2025)  Identification and molecular mechanisms of novel antioxidant peptides from Manila clam hydrolysate: Caenorhabditis elegans model, molecular simulations, and quantum chemistry.  FOOD CHEMISTRY,      [PMID:40516351] [10.1016/j.foodchem.2025.145079]
222. Hongjuan Cui, Yan Zhao, Wei Li, Huanjie Cui, Jiahong Han, Enbo Cai.  (2025)  Design, Synthesis, Anti-Tumor Activity and Molecular Docking Studies of Novel Triphenylphosphine-Containing Formononetin Derivatives.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  26  (11): (5280).  [PMID:40508093] [10.3390/ijms26115280]
223. Si-qi Zhang, Si-mei Liu, Zi-long Chen, Ke Guo, Xin-xin Yang, Li-hua Zhang, Ya-feng Yan, Ting-ting Zhang, Peng Zhao.  (2025)  Extraction, Structural Analysis, and Bioactivity of a Novel Polysaccharide From Corydalis yanhusuo Residues.  Chemical Biology & Drug Design,  105  (6): (e70115).  [PMID:40495313] [10.1111/cbdd.70115]
224. Siyue Wang, Xiaotian Guan, Shuqing Sun.  (2025)  CRISPR/Cas12a-Based Aptasensor Enhanced by Functionalized AuNPs for Sensitive Full-Range C-Reactive Protein Detection.  Journal of Materials Chemistry B,      [PMID:41170688] [10.1039/D5TB01727K]
225. Shiyu Qin, Zijun Liu, Hongliang Wei, Qiaoran Zhang, Gang Wang, Yu Liu, Tao Guo, Meng Yan, Hongli Chen.  (2025)  Facile one-pot construction of starch-based hydrogel with interpenetrating network structure via azide-maleimide click reaction and photopolymerization in water.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2025.128898]
226. Han Chen, Jin Su, Wenhui Cheng, Linwen Wen, Meiqi Huang, Xuejiao Li, Wei Cai, Qian Ning, Liangjun Guan.  (2025)  Folate-targeted long-circulating 5-fluorouracil liposomes: preparation, characterization, anti-tumor effect and pharmacokinetic profile in rats.  JOURNAL OF LIPOSOME RESEARCH,      [PMID:41086347] [10.1080/08982104.2025.2571625]
227. Qian Luo, Chen Sun, Xue Zhao, Er-Wei Li, Yu-Qing Yi, Yang Zhang, Shuai-Ming Zhu, Yu Yang, Rui Xu, Li-Xia Chen, You-Zhi Zhang, Chang-Wei Li.  (2025)  Cytochalasinols A and B, Two New Cytochalasins From the Fungus Xylaria necrophora SZSS1-2-2.  CHEMISTRY & BIODIVERSITY,      [PMID:41289054] [10.1002/cbdv.202503213]
228. Fengxue Liu, Xuefei Yu, Yanmei Wu, Ting Zhu, Ning Chen, Hao Chen, Wei Shen, Wei Zheng.  (2025)  Novel PLA-based shape-memory formulation: Design, preparation, and evaluation for gastro-retentive delivery of 5-fluorouracil to enhance oral bioavailability.  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,      [PMID:41422985] [10.1016/j.ejpb.2025.114968]
229. Wang Jiahui, Li Shuqi, Lei Zichen, Xing Yantao, Li Jieshu, Guo Jie, Duan Boshi, Liu Yonggang.  (2025)  Multi-target synergistic anti-aging: QG extends Caenorhabditis elegans lifespan through DAF-16/FOXO pathways, mitochondrial homeostasis and metabolic reprogramming.  BIOGERONTOLOGY,  27  (1): (6).  [PMID:41251816] [10.1007/s10522-025-10347-3]
230. Peng Cao, Qilin Li, Yuyu Li, Honglian Guo, Chunyu Wei, Rengui Xu, Chenke Ouyang, Wei Chen, Lin Wang, Zheng Wang.  (2025)  Manganese-engineered Lactobacillus Reuteri with enhanced antitumor and immunomodulatory activities for colorectal cancer prevention and treatment.  Nature Communications,      [PMID:41413024] [10.1038/s41467-025-67437-6]
231. Di Zhang, Yujiang Dai, Xin Wang, Qi Mai, Lu Jiang, Tuanjie Wang, Huifang Li, Xing Ren, Rongbin Wei.  (2026)  An undescribed biflavone from coastal halophyte Suaeda maritima subsp. salsa (L.) Soó.  NATURAL PRODUCT RESEARCH,      [PMID:41518651] [10.1080/14786419.2026.2613341]
232. Sai-Nan Qin, Yi-Xue Zhang, Yi-Jie Cao, Ting Wan, Yi-Yang Zhou, Shan-Shan Su, Yu-Qiong Guo, Jian-Jun Sun, Kalle Salminen.  (2026)  A self-assembled electrochemical aptasensor for one-step rapid detection of cisplatin in blood via aptamer conformational change.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2026.116962]
233. Xiaoyan Liu, Yang Li, Changjing Qiu, Zhongming Liu, Shoujuan Wang, Fangong Kong.  (2026)  Design and characterization of a pH-responsive carboxylated cellulose nanofibril composite aerogel for enhanced drug delivery.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:41633458] [10.1016/j.ijbiomac.2026.150677]
234. Wenqian Bai, Miaomiao Li, Junyao Li, Wenrong Cai, Yong Kong, Haiying Chen.  (2026)  Metal–Organic Framework and 5-Fluorouracil Co-Encapsulated Hyaluronic Acid/Carboxymethyl Chitosan Hydrogels for Synergistic Chemotherapy and Enhanced Chemodynamic Therapy.  MOLECULAR PHARMACEUTICS,      [PMID:41582519] [10.1021/acs.molpharmaceut.5c01519]
235. Mengxue Sun, Qing Sun, Jiawei Sheng.  (2026)  Concise and eco-friendly: Stable anchoring of cobalt nanoparticles embedded in MXene via CaCl2 for boosting degradation of 5-fluorouracil.  Surfaces and Interfaces,      [PMID:] [10.1016/j.surfin.2026.108726]
236. Yanlong Shi, Sentai Ding, Zexin Wang, Leping Li, Jinshen Wang, Sepehr Mehdizadeh, Younes Pilehvar.  (2026)  Hydrogel-mediated tri-modal nanoplatform for localized colorectal cancer therapy via smart chemo-photothermal-radiotherapy.  Journal of Biological Engineering,      [PMID:41652605] [10.1186/s13036-026-00633-0]
237. Hongyu Lin, Huwei Bian, Junyao Li, Laidi Xu, Tao Jiang, Yong Kong.  (2026)  A pH-Responsive Controlled Release Platform Based on Honeycomb MnO2/Carboxymethyl Chitosan/Oxidized Hyaluronic Acid for Multimodal Therapy of Breast Cancer.  MOLECULAR PHARMACEUTICS,      [PMID:41609314] [10.1021/acs.molpharmaceut.5c01660]
238. Zhang Ran, Tang Liqing, He Jianglong, Jiang Guanyu, Su Yingfei, Jiang Xueping, Wu Ping, Zhang Dongyang, Chen Sitong, Li Hao, Gui Zhongzheng.  (2026)  A multifunctional 5-fluorouracil prodrug: synthesis, biological evaluation, and antitumor mechanism investigation.  MOLECULAR DIVERSITY,      [PMID:41706295] [10.1007/s11030-025-11445-7]
239. Xiaoliang Zhao, Lixia Xiong, Haidong Wen, Yuanyuan Ma, Yuxin Wang, Cunjin Wang, Pengcheng Shao, Jing Zhang, Yuhui Zhao, Ji Zhang, Weijie Zhang.  (2026)  Ultrasound-Assisted Extraction, Chemical Modification, Structural Characterization, and Activity Studies of Polysaccharides From Corn Silk.  CHEMISTRY & BIODIVERSITY,  23  (3): (e03369).  [PMID:] [10.1002/cbdv.202503369]
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