Indomethacin , CAS No.53-86-1

CAS: 53-86-1 Cat. No.: I1372187-GMP Molecular Weight: 357.79 Beilstein Registry Number: 497341 EC Number: 200-186-5

Storage

Room temperature

Shipped In

Normal

Overview

Indomethacin (GMP) is Indomethacin produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Indomethacin (Indometacin) is a potent COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research.

Specifications

Storage

Room temperature

Shipped In

Normal

Product Properties

• ALogP: 4.3

Names and Identifiers

• Canonical Smiles: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O
• IUPAC Name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
• InChIKey: CGIGDMFJXJATDK-UHFFFAOYSA-N
• INCHI: 1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
• Isomeric SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O
• WGK Germany: 3
• RTECS: NL3500000
• UN Number: 2811
• Packing Group: I
• Molecular Weight: 357.79
• Beilstein: 497341
• Reaxy-Rn: 497341
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=497341&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Indoles and derivatives
      • Subclass Benzoylindoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Indoles and derivatives
• Subclass: Benzoylindoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzoylindoles
• Alternative Parents: Indole-3-acetic acid derivatives Indolecarboxylic acids and derivatives 3-alkylindoles 4-halobenzoic acids and derivatives Anisoles Benzoyl derivatives Alkyl aryl ethers Chlorobenzenes Substituted pyrroles Aryl chlorides Heteroaromatic compounds Monocarboxylic acids and derivatives Azacyclic compounds Carboxylic acids Organonitrogen compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds Organochlorides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzoylindole - Indole-3-acetic acid derivative - Indolecarboxylic acid derivative - Indolyl carboxylic acid derivative - 4-halobenzoic acid or derivatives - Halobenzoic acid or derivatives - 3-alkylindole - Indole - Benzoic acid or derivatives - Anisole - Benzoyl - Chlorobenzene - Alkyl aryl ether - Halobenzene - Benzenoid - Substituted pyrrole - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Heteroaromatic compound - Pyrrole - Carboxylic acid derivative - Carboxylic acid - Ether - Azacycle - Monocarboxylic acid or derivatives - Hydrocarbon derivative - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Organopnictogen compound - Organic oxide - Organohalogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as benzoylindoles. These are organic compounds containing an indole attached to a benzoyl moiety through the acyl group.
• External Descriptors: a small molecule

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Melt Point(°C): 158-162°C

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62. Li Lili, Zhang Sheng, Xin Yanfei, Sun Junying, Xie Feng, Yang Lin, Chen Zhiqin, Chen Hao, Liu Fang, Xuan Yaoxian, You Zhenqiang.  (2018)  Role of Quzhou Fructus Aurantii Extract in Preventing and Treating Acute Lung Injury and Inflammation.  Scientific Reports,  8  (1): (1-11).  [PMID:29374248] [10.1038/s41598-018-20083-z]

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64. Weiping Ji, Bo Wang, Qiuping Fan, Chao Xu, Youwu He, Youfen Chen.  (2017)  Chemosensitizing indomethacin-conjugated dextran-based micelles for effective delivery of paclitaxel in resistant breast cancer therapy.  PLoS One,  12  (7): (e0180037).  [PMID:28686704] [10.1371/journal.pone.0180037]

65. Xian Sun, Yingping Luo, Liwei Huang, Bo-Yang Yu, Jiangwei Tian.  (2017)  A peptide-decorated and curcumin-loaded mesoporous silica nanomedicine for effectively overcoming multidrug resistance in cancer cells.  RSC Advances,  7  (27): (16401-16409).  [PMID:] [10.1039/C7RA01128H]

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67. Xiaoye Yang, Xiaoqing Cai, Aihua Yu, Yanwei Xi, Guangxi Zhai.  (2017)  Redox-sensitive self-assembled nanoparticles based on alpha-tocopherol succinate-modified heparin for intracellular delivery of paclitaxel.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:28237749] [10.1016/j.jcis.2017.02.033]

68. Xinfeng Cheng, Yong Jin, Rui Qi, Wuhou Fan, Hanping Li, Xiaopeng Sun, Shuangquan Lai.  (2016)  Dual pH and oxidation-responsive nanogels crosslinked by diselenide bonds for controlled drug delivery.  POLYMER,      [PMID:] [10.1016/j.polymer.2016.08.087]

69. Yuxia Liu, Zhenfa Zhang, Cuizong Zhang, Wei Huang, Caiyun Liang, Jinyun Peng.  (2016)  Manganese dioxide-graphene nanocomposite film modified electrode as a sensitive voltammetric sensor of indomethacin detection.  BULLETIN OF THE KOREAN CHEMICAL SOCIETY,  37  (8): (1173-1179).  [PMID:] [10.1002/bkcs.10815]

70. Jihui Wang, Yuan Liang, Luyang Jian, Jingwei Zhang, Shuai Liang, Shan Xiao, Bingnan Liu, Han Wang.  (2016)  Linoelaidic acid enhances adipogenic differentiation in adipose tissue-derived stromal cells through suppression of Wnt/β-catenin signaling pathway in vitro.  PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS,      [PMID:27255637] [10.1016/j.plefa.2016.04.004]

71. Zhao Gao, Yu Han, Yunhui Hu, Xiaoyan Wu, Yongbin Wang, Xiaoqun Zhang, Jinjuan Fu, Xue Zou, Jun Zhang, Xiongwen Chen, Pedro A. Jose, Xi Lu, Chunyu Zeng.  (2016)  Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.  PLoS One,  11  (2): (e0149032).  [PMID:26866373] [10.1371/journal.pone.0149032]

72. Xinfeng Cheng, Yong Jin, Tongbing Sun, Rui Qi, Hanping Li, Wuhou Fan.  (2016)  An injectable, dual pH and oxidation-responsive supramolecular hydrogel for controlled dual drug delivery.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:26851440] [10.1016/j.colsurfb.2016.01.034]

73. Jinda Fang, Ke Zhang, Jingwei Jia, Zhengke Wang, Qiaoling Hu.  (2015)  Preparation and characterization of N-phthaloyl-chitosan-g-(PEO–PLA–PEO) as a potential drug carrier.  RSC Advances,  5  (120): (99418-99424).  [PMID:] [10.1039/C5RA12984B]

74. Qing Wang, Yao Long, Lin Yao, Li Xu, Zhi-Guo Shi, Lanying Xu.  (2015)  Preparation, characterization and application of a reversed phase liquid chromatography/hydrophilic interaction chromatography mixed-mode C18-DTT stationary phase.  TALANTA,      [PMID:26695288] [10.1016/j.talanta.2015.09.009]

75. Qing Wang, Zhi-Yuan Luo, Mao Ye, Yu-Zhuo Wang, Li Xu, Zhi-guo Shi, Lanying Xu.  (2015)  Preparation, chromatographic evaluation and application of adenosine 5′-monophosphate modified ZrO2/SiO2 stationary phase in hydrophilic interaction chromatography.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:25627970] [10.1016/j.chroma.2015.01.017]

76. Qian Wang, Shuang-ting Wang, Xin Yang, Pan-pan You, Wen Zhang.  (2015)  Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes.  NUTRITION RESEARCH,      [PMID:25724338] [10.1016/j.nutres.2014.12.009]

77. Qingchun Zhang, Ke Tan, Yan Zhang, Zhaoyang Ye, Wen-Song Tan, Meidong Lang.  (2013)  In Situ Controlled Release of rhBMP-2 in Gelatin-Coated 3D Porous Poly(ε-caprolactone) Scaffolds for Homogeneous Bone Tissue Formation.  BIOMACROMOLECULES,      [PMID:24266740] [10.1021/bm401309u]

78. Xiaohong Wang, Guohua Jiang, Zhen Wei, Xia Li, Bolin Tang.  (2013)  Preparation and drug release property of CO2 stimulus-sensitive poly(N, N-dimethylaminoethyl methacrylate)-b-polystyrene nanoparticles.  EUROPEAN POLYMER JOURNAL,      [PMID:] [10.1016/j.eurpolymj.2013.07.024]

79. Zhiyao Hou, Xuejiao Li, Chunxia Li, Yunlu Dai, Ping’an Ma, Xiao Zhang, Xiaojiao Kang, Ziyong Cheng, Jun Lin.  (2013)  Electrospun Upconversion Composite Fibers as Dual Drugs Delivery System with Individual Release Properties.  LANGMUIR,      [PMID:23855606] [10.1021/la402080y]

80. Juan Chen, Ying-Xin Tang, Yong-Ming Liu, Ji Chen, Xiao-Qing Hu, Na Liu, Shu-Xin Wang, Yu Zhang, Wen-Gao Zeng, Hou-Jie Ni, Bin Zhao, Yan-Fang Chen, Zhou-Ping Tang.  (2012)  Transplantation of Adipose-Derived Stem Cells is Associated with Neural Differentiation and Functional Improvement in a Rat Model of Intracerebral Hemorrhage.  CNS Neuroscience & Therapeutics,  18  (10): (847-854).  [PMID:22934896] [10.1111/j.1755-5949.2012.00382.x]

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82. MengYing Lei, Qing Chen, Yang Wang, Gang Wang.  (2024)  A facile carrier-free co-assembly nanoplatform for effective enhanced oral chemotherapy.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2024.105651]

83. Sisi Yi, Tao Guo, Yan Wang, Xiaodi Yang, Yue Liao, Xiyu Tang, Xiangjun Zhang.  (2024)  A micrometer sized porous β-cyclodextrin polymer for improving bioavailability of poorly soluble drug.  CARBOHYDRATE POLYMERS,      [PMID:39647945] [10.1016/j.carbpol.2024.123042]

84. Junying Li, Xiaoxiao Shan, Yu Gao, Haizhou Zhu, Hongyan Cheng, Chengjie Xing, Lele Zhou, Wenkang Tao, Yangyang Li, Baoqi Yin, Caiyun Zhang.  (2025)  Acori Tatarinowii Rhizoma regulates OCT3/OATP2 and P-gp/MRP1 to “guide medicines upwards” in Kai-Xin-San to treat Alzheimer's disease.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:39947370] [10.1016/j.jep.2025.119484]

85. Zhiren Yao, Tian Li, Meiling Jin, Siyang Fang, Jie Wang, Jiaming Zheng, Ke Pan, Jian Zhang, Guoqing Zhao, Zhiqi Yin, Yaping Huang.  (2024)  Bioactivity-Oriented Separation of “Pepper Alkaloids” from Piper sintenense Hatusima with Potential Antigouty Arthritis Activity.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:39432871] [10.1021/acs.jafc.4c05999]

86. Wenhao Zhou, Xiaoqin Zheng, Xilei Wang, Yinghan Tian, Yi Wen, Yijun Tu, Jiachuan Lei, Hong Cheng, Jianqing Yu.  (2024)  Bioassay-guided isolation of antibacterial and anti-inflammatory components from Atractylodes lancea.  PHYTOCHEMISTRY,      [PMID:39097216] [10.1016/j.phytochem.2024.114232]

87. Yan Gan, Haotian Han, Ying Zhang, Ziwei Zhou, Xiang Shen, Jianjun Fang, Lei Cui, Zhihua Zhou.  (2025)  Chitosan-based injectable porous microcarriers with enhanced adipogenic differentiation and angiogenesis for subcutaneous adipose tissue regeneration.  Biomaterials Advances,      [PMID:39756088] [10.1016/j.bioadv.2025.214174]

88. Gao Hong-Xue, Liu Zhi-Qiang, Hou Zong, Song Feng-Rui, Xing Jun-Peng, Zheng Zhong, Liu Shu.  (2024)  Comprehensive Screening and Evaluation of Anti-gout Activity of Plantago asiatica L. through Integrated In vivo and In vitro Methodologies.  World Journal of Traditional Chinese Medicine,      [PMID:] [10.4103/wjtcm.wjtcm_75_24]

89. Zhaorui Qi, Xurui Li, Yueming Zhu, Li Li, Yu Liu.  (2024)  Construction and Evaluation of pH-Responsive Nitrogen-Containing Metal–Organic Frameworks as Oral Drug Carriers.  APPLIED ORGANOMETALLIC CHEMISTRY,      [PMID:] [10.1002/aoc.7675]

90. Wei Gu, Qinfu Zhao, Ye He, Shengyu Wang, Yuanqi Yang, Yian Li, Shuaipeng Feng, Siling Wang.  (2024)  Different mesoporous carbon carriers for the improvement of solubility and physical stability of poorly soluble drugs.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:39705828] [10.1016/j.colsurfb.2024.114436]

91. Xiaoxiao Liang, Shiyuan Liu, Zebin Li, Yuehua Deng, Yanbin Jiang, Huaiyu Yang.  (2024)  Efficient cocrystal coformer screening based on a Machine learning Strategy: A case study for the preparation of imatinib cocrystal with enhanced physicochemical properties.  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,      [PMID:38309538] [10.1016/j.ejpb.2024.114201]

92. Anyi Zhao, Jiangmin Su, Qingxia Xu, Jun Zhang, Jinzhu Jiang, Sha Chen, Jintang Cheng, Chang Chen, Lianmei Wang, Jipeng Di, Xianju Liu, Liang Jiang, Li Liu, Yan Liu, An Liu, Cong Guo.  (2024)  Elucidation of anti-pneumonia pharmacodynamic material basis and potential mechanisms of Xiebai San by combining spectrum–efficacy relationship and surface plasmon resonance.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:39053707] [10.1016/j.jep.2024.118609]

93. Yuting Liu, Yinyu Chen, Huiying Ding, Jingchuan Xue, Yang Yang, Xianhui Li.  (2024)  Enhancing PPCP and salt separation in polyamide nanofiltration membranes with polydopamine and ZnO functionalized nanofiber support.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2024.123525]

94. Tao Zhao, Minghao Xu, Xuerui Yang, Jean-Marc Chovelon, Lei Zhou.  (2025)  Exploring the reactivity of high-valent copper species with emerging contaminants using predictive QSAR modelling.  ENVIRONMENTAL TECHNOLOGY,      [PMID:40163592] [10.1080/09593330.2025.2485363]

95. Yanjun Cheng, Huiying Ding, Yuting Liu, Di He, Lu Elfa Peng, Hideto Matsuyama, Mengyang Hu, Xianhui Li.  (2024)  Fabrication of polyethersulfone/sulfonated polysulfone loose nanofiltration membranes for enhanced selectivity of pharmaceuticals and personal care products and minerals.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2024.126466]

96. Xiaoyuan Yan, Na An, Zeying Zhang, Qiujing Qiu, Di Yang, Penggong Wei, Xiyue Zhang, Lihong Qiu, Jiajie Guo.  (2024)  Graphene Oxide Quantum Dots-Preactivated Dental Pulp Stem Cells/GelMA Facilitates Mitophagy-Regulated Bone Regeneration.  International Journal of Nanomedicine,      [PMID:39381026] [10.2147/IJN.S480979]

97. An Na, Yan Xiaoyuan, Qiu Qiujing, Zhang Zeying, Zhang Xiyue, Zheng Bowen, Zhao Zhenjin, Guo Jiajie, Liu Yi.  (2024)  Human periodontal ligament stem cell sheets activated by graphene oxide quantum dots repair periodontal bone defects by promoting mitochondrial dynamics dependent osteogenic differentiation.  JOURNAL OF NANOBIOTECHNOLOGY,  22  (1): (1-20).  [PMID:38539195] [10.1186/s12951-024-02422-7]

98. Mengxian Wang, Zeping Yu, Xinlong Li, Junqiao Li, Jianshu Li, Jun Luo, Jiyao Li, Yan Xiong, Jiaojiao Yang.  (2025)  In situ dual-targeted drug delivery system for alleviating imaging and pathological damage in septic arthritis.  Acta Biomaterialia,      [PMID:39922516] [10.1016/j.actbio.2025.02.014]

99. Peng Wang, Haifan Wang, Yang Xiao, Jialiang Zou, Hongping Chen, Lin Chen, Fu Wang, Yuan Hu, Youping Liu.  (2024)  Insights into metabolic characteristics and biological activity changes in Zangju (Citrus reticulata cv. Manau Gan) peel at different maturity stages through UPLC–MS/MS-based metabolomics.  Food Chemistry-X,      [PMID:38357370] [10.1016/j.fochx.2024.101197]

100. Ze Li, Jing Yuan, Yue Dai, Yufeng Xia.  (2024)  Integration of serum pharmacochemistry and metabolomics to reveal the underlying mechanism of shaoyao-gancao-fuzi decoction to ameliorate rheumatoid arthritis.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:38373664] [10.1016/j.jep.2024.117910]

101. Jing Xu, Xiu-Wei Yang.  (2024)  LC-MS-Based Metabolomics Reveals the Mechanism of Protection of Berberine against Indomethacin-Induced Gastric Injury in Rats.  MOLECULES,  29  (5): (1055).  [PMID:38474567] [10.3390/molecules29051055]

102. Wang Aiping, Ning Jie, Zhao Lu, Xu Renjie.  (2024)  Lipid-lowering effect and oral transport characteristics study of curculigoside.  Frontiers in Cardiovascular Medicine,      [PMID:39015683] [10.3389/fcvm.2024.1426379]

103. Li Bo, Zhao Qianhui, Yang Hanyu, Wang Xueyuying, Zhang Zhijun, Gong Yanling, Wan Xu.  (2024)  Long-Circulating and Targeted Liposomes Co-loading Cisplatin and Mifamurtide: Formulation and Delivery in Osteosarcoma Cells.  AAPS PHARMSCITECH,  25  (8): (1-12).  [PMID:39592553] [10.1208/s12249-024-02992-7]

104. Yadan Zhang, Xiaoyu Zhang, Tianhan Kai, Lin Zhang, Anping Li.  (2024)  Lycium ruthenicum Murray derived exosome-like nanovesicles inhibit Aβ-induced apoptosis in PC12 cells via MAPK and PI3K/AKT signaling pathways.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39089544] [10.1016/j.ijbiomac.2024.134309]

105. Lian Xu, Yan Xiao, Kun Yu, Hongshuo Pan, Jiayi Xu, Yiyun Guan, Mengke Wang, Xiangyu Xu, Hao Wang.  (2025)  Machine Learning-Assisted Chemical Tongues Based on Dual-channel Inclusion Complexes for Rapid Identification of Nonsteroidal Anti-inflammatory Drugs in Food.  ACS Sensors,      [PMID:39992799] [10.1021/acssensors.4c02806]

106. Xin Qiao, Xiaojuan Cao, Shuang Xu, Cunlin Wang, Rui Guo, Xiaojuan Yao, Qiong Zhang.  (2024)  Menisoxoisoaporphine A, a novel oxoisoaporphine alkaloid from Menispermi Rhizoma, inhibits inflammation by targeting PDE4B.  Frontiers in Pharmacology,      [PMID:39691395] [10.3389/fphar.2024.1505116]

107. Irfan Ijaz, Aysha Bukhari, Ammara Nazir, Ezaz Gilani, Hina Zain, Attia Shaheen, Mohammed Rafi Shaik, Mujeeb Khan.  (2025)  Modification of bacterial cellulose by MoBTx MBene and 1,4-dithiothreitol for rapid and efficient adsorption of indomethacin and losartan potassium.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39922337] [10.1016/j.ijbiomac.2025.140745]

108. Xiangyi Liu, Lulu Du, Jia Liu, Yueting Shi, Qipeng Liu, Ying Xu, Yingying Xia, Xiaiting Wang, Dan Ding, Xingyi Li, Deqing Lin.  (2024)  NaCl-Responsive Ultrashort Peptide to Trigger Self-Assembly of TPE-Capped Supramolecular Hydrogelator.  BIOMACROMOLECULES,      [PMID:39621541] [10.1021/acs.biomac.4c01050]

109. Li Guo, Sai Zhang, Cong Zhang, Shuang Ren, Zihan Zhou, Fengyuan Wang, Yuexuan Wang, Qiqi Chen, Yubing Wang, Wen-Hui Lee, Kui Zhu, Di Qin, Yuanyuan Gao, Tongyi Sun.  (2024)  Novel analgesic peptide derived from Cinobufacini injection suppressing inflammation and pain via ERK1/2/COX-2 pathway.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:39159558] [10.1016/j.intimp.2024.112918]

110. Yuhan Yang, Yangyi Chen, Yue Wei, Wei Wu, Qing Wang, Tianyun Xue, Xiaoyan Zhang, Wei Chen, Wei Zhang.  (2024)  Novel Silybin-Conjugated Chitosan Polymeric Micelles for Improving the Oral Absorption of Doxorubicin Based on the Inhibition of P-gp and CYP3A4.  BIOMACROMOLECULES,      [PMID:39418531] [10.1021/acs.biomac.4c00628]

111. Tang Bo, Wang Qiuxiang, Zhang Guowei, Zhang Aiwen, Zhu Lu, Zhao Rongrong, Gu Hongwei, Meng Jie, Zhang Junfang, Fang Guihua.  (2024)  OCTN2- and ATB0,+-targeted nanoemulsions for improving ocular drug delivery.  JOURNAL OF NANOBIOTECHNOLOGY,  22  (1): (1-19).  [PMID:38532399] [10.1186/s12951-024-02402-x]

112. Shu-Hang Li, Meng-Ying Li, Tao-Tao Yuan, Guo-Wei Wang, Jian-Bin Zeng, Zhimian Shi, Jian-Hang Liu, Jun-Cheng Su.  (2024)  Osthole Activates the Cholinergic Anti-Inflammatory Pathway via α7nAChR Upregulation to Alleviate Inflammatory Responses.  CHEMISTRY & BIODIVERSITY,      [PMID:38389159] [10.1002/cbdv.202400290]

113. Yang Yu, Lixin Fan, Chunling Gao, Yang Ping, Liting Mu, Weitong Sun.  (2025)  Preparation and antitumor activity of reduction-sensitive pre-drug micelles loaded with paclitaxel.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2025.136376]

114. Yi Hao, Jian Shang, Shuyan Liu, Xuemeng Tian, Xin Yao, Fengjun Liu, Ruizhen Zhu, Yue Wang, Ruixia Gao, Sicen Wang.  (2025)  Preparation of protein-resistant magnetic molecularly imprinted polymers as solid-phase extraction adsorbents via a one-stone-two-birds strategy for selective enrichment of tetracycline in milk.  TALANTA,      [PMID:39904252] [10.1016/j.talanta.2025.127678]

115. Huijuan Yang, Hailong Li, Yuxin Liu, Jinrui Jiang, Mei Hai, Cong Li, Zhiqiang Hu, Ru Zhou.  (2024)  The Vasodilator Effect and Mechanism of 18β-glycyrrhetinic Acid on Isolated Pulmonary Artery Rings in Rats.  Pharmacognosy Magazine,      [PMID:] [10.1177/09731296241241115]

116. Lin Liang, Xi Yuan, Xiao-Ya Xian, Xian-Li Zhou, Tong-Dong Kuang, Jin-Tao Gao, Li-Sheng Wang, Cheng-Qin Liang.  (2024)  Two new quinazolinone alkaloids from Aspergillus udagawae.  JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,      [PMID:39552573] [10.1080/10286020.2024.2424910]

117. Shuiling Qin, Zhiwei Wen, Huajie Huang, Wei Wu.  (2024)  Use of novel taurine-chitosan mediated liposomes for enhancing the oral absorption of doxorubicin via the TAUT transporter.  CARBOHYDRATE POLYMERS,      [PMID:38286550] [10.1016/j.carbpol.2024.121780]

118. Yaxin Zheng, Lu Sun, Ziran Zhai, Fangling Cao, Tingting Zhang, Qishu Jiao, Keming Xu, Wenying Zhong.  (2024)  Wound microenvironment-responsive dually cross-linked nanofibrillar peptide hydrogels for efficient hemostatic control and multi-faceted wound management.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38171439] [10.1016/j.ijbiomac.2023.129133]

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120. Xiaofei Han, Jia Chen, Zhan Li, Kaijun Quan, Hongdeng Qiu.  (2020)  Magnetic solid-phase extraction of triazole fungicides based on magnetic porous carbon prepared by combustion combined with solvothermal method.  ANALYTICA CHIMICA ACTA,      [PMID:32891394] [10.1016/j.aca.2020.06.077]

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122. Yiyao Li, Huixian Tian, Han Zeng, Yu Zhang, Tian Yin, Haibing He, Jingxin Gou, Xing Tang.  (2025)  Chitosan based surface modulation of core-shell nanoparticles for oral delivery of exenatide via balancing mucus penetration and cellular uptake.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:39921014] [10.1016/j.ijpharm.2025.125319]

123. Longyan Yang, Ruili Yin, Ziyu Shan, Anqi Feng, Kun Li, Yan Wang, Ke Yu, Yongsong Xu, Lin Mao, Jianan Lang, Baoyu Zhang, Dong Zhao.  (2025)  Adipocyte-secreted ANGPTL2 promotes hyperuricemia through inhibiting AKT/ABCG2 signaling.  FREE RADICAL BIOLOGY AND MEDICINE,      [PMID:40180020] [10.1016/j.freeradbiomed.2025.03.048]

124. Ying Zhang, Jingjing Liu, Ling Yin, Chengyun Yan, Bingli Jiang, Yueyi Deng.  (2025)  Three indomethacin cocrystals: Preparation, characterization and formation thermodynamics.  CHEMICAL ENGINEERING RESEARCH & DESIGN,      [PMID:] [10.1016/j.cherd.2025.04.048]

125. Wenling Zheng, Junni Ke, Kaerdun Liu, Rongrong Xue, Fenghua Chen.  (2025)  Aqueous Solution Spray Drying Preparations of Binary Amorphous Solid Dispersions.  Crystals,  15  (4): (323).  [PMID:] [10.3390/cryst15040323]

126. Shirong Li, Junwen Ding, Zihan Liu, Jinjin Jia, Qian Zhao, Peijie Li, Han Zhang, Guibai Li, Langming Bai, Heng Liang.  (2025)  Interface-Facilitated Removal of Environmental Micropollutants by Nanofiltration Membranes Prepared from Amino Acid-Mediated Interfacial Polymerization: Mechanistic Insights into Micropollutant Interfacial Partitioning Regulation.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:40493848] [10.1021/acs.est.5c04586]

127. Zhang Zehong, Wan Qianyi, Zhu Yuedan, Ye Jinbao, Fu Fang, Fan Xinxin, Chen Haiou, Ren Gang, Jiang Wei, Guo Xiaoxin, Zhou Juanyu, Yan La, Yan Jinhua, Liu Xingzhu, Yuan Yu, Chen Yi, Chen Haiyang.  (2025)  Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging.  Nature Communications,  16  (1): (1-20).  [PMID:40593722] [10.1038/s41467-025-61070-z]

128. Mi Wang, Tianqi Liu, Hao Wang, Zhenyuan Wang, Jiaheng Zhang.  (2025)  A Supramolecular System of Bioactive Ionic Liquid, Peony Extract, and Peptide for Enhanced Permeability and Synergistic Skincare Benefits.  CHEMISTRY-A EUROPEAN JOURNAL,      [PMID:40522284] [10.1002/chem.202501323]

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130. Yating Li, Jianrong Huo, Shilong Yu, Yifan Xiang, Yanrong Feng, Zongyou Jiang, Shaoqi Gao, Zhongzuo Huang, Yichen Luo, Yu Xin, Jinyan Yu, Bo Wang, Junxing Zhao.  (2025)  Maternal Taurine Supplementation Enhances Thermogenesis of Newborn Lambs by Promoting Brown Adipogenesis.  FASEB JOURNAL,  39  (20): (e71185).  [PMID:41139244] [10.1096/fj.202502140RR]

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