Selonsertib (GS-4997) - Moligand™, 10mM in DMSO , Mitogen-activated protein kinase kinase kinase 5 inhibitor, CAS No.1448428-04-3, Mitogen-activated protein kinase kinase kinase 5 inhibitor

CAS: 1448428-04-3 Cat. No.: S408220 Molecular Weight: 445.49 EC Number: 822-332-2 PubChem CID: 71245288

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Benzamide, 5-​(4-​cyclopropyl-​1H-​imidazol-​1-​yl)​-​2-​fluoro-​4-​methyl-​N-​[6-​[4-​(1-​methylethyl)​-​4H-​1,​2,​4-​triazol-​3-​yl]​-​2-​pyridinyl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Selonsertib (GS-4997) Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
In vitro

In vivo

An orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. Upon oral administration, ASK1 inhibitor GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. This prevents the phosphorylation of downstream kinases, such as c-Jun N-terminal kinases (JNKs) and p38 mitogen-activated protein kinase (p38 MAPK). By preventing the activation of ASK1-dependent signal transduction pathways, GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Benzamide, 5-​(4-​cyclopropyl-​1H-​imidazol-​1-​yl)​-​2-​fluoro-​4-​methyl-​N-​[6-​[4-​(1-​methylethyl)​-​4H-​1, ​2, ​4-​triazol-​3-​yl]​-​2-​pyridinyl]​-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Mitogen-activated protein kinase kinase kinase 5 inhibitor

Product Properties

• ALogP: 4.054
• HBD Count: 1
• Rotatable Bond: 6

Names and Identifiers

• Isomeric SMILES: CC1=CC(=C(C=C1N2C=C(N=C2)C3CC3)C(=O)NC4=CC=CC(=N4)C5=NN=CN5C(C)C)F
• PubChem CID: 71245288
• Molecular Weight: 445.49

Associated Targets(Human)

MAP3K5 Tchem Mitogen-activated protein kinase kinase kinase 5 (1 Activities)

Discover Target: MAP3K5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• DMSO(mg / mL) Max Solubility: 36
• DMSO(mM) Max Solubility: 80.80989472
• Water(mg / mL) Max Solubility: ＜1