TCS 359 - Moligand™, 10mM in DMSO , Inhibitor of fms related receptor tyrosine kinase 3, CAS No.301305-73-7, Inhibitor of fms related receptor tyrosine kinase 3

CAS: 301305-73-7 Cat. No.: T408702 Molecular Weight: 360.43 EC Number: 636-890-8 PubChem CID: 1048845

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Benzo[b]thiophene-3-carboxamide, 2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

TCS 359 TCS 359 is a potent FLT3 inhibitor with IC50 of 42 nM.
In vitro

TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM. TCS 359 inhibits MV4-11 proliferation with IC50 of 340 nM. TCS 359 is highly selective for FLT3 against a panel of kinases.

In vivo

Cell Data

cell lines：

Concentrations：~5 μM

Incubation Time：72 hours

Powder Purity:≥99%

Specifications

Synonyms

Benzo[b]thiophene-3-carboxamide, 2-[(3, 4-dimethoxybenzoyl)amino]-4, 5, 6, 7-tetrahydro-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

TCS 359 is a potent FLT3 inhibitor with IC50 of 42 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of fms related receptor tyrosine kinase 3

Names and Identifiers

• Isomeric SMILES: COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC
• WGK Germany: 3
• PubChem CID: 1048845
• Molecular Weight: 360.43

Associated Targets(Human)

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 (1 Activities)

Discover Target: FLT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)