≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature Ships FedEx DG Service Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 16 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Product Application：
Tetrahydrothiophene can be used as a reagent for the synthesis of various epoxides and their derivatives. It can be used as a catalyst for the synthesis of benzo[n.1.0]bicycloalkanes.
| Pubchem Sid | 504750465 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504750465 |
| Canonical Smiles | C1CCSC1 |
| IUPAC Name | thiolane |
| InChIKey | RAOIDOHSFRTOEL-UHFFFAOYSA-N |
| INCHI | 1S/C4H8S/c1-2-4-5-3-1/h1-4H2 |
| Isomeric SMILES | C1CCSC1 |
| WGK Germany | 2 |
| RTECS | XN0370000 |
| PubChem CID | 1127 |
| UN Number | 2412 |
| Packing Group | II |
| Molecular Weight | 88.17 |
| Beilstein | 102392 |
| Reaxy-Rn | 102392 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Thiolanes |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Thiolanes |
| Alternative Parents | Dialkylthioethers Hydrocarbon derivatives |
| Molecular Framework | Aliphatic heteromonocyclic compounds |
| Substituents | Thiolane - Dialkylthioether - Thioether - Hydrocarbon derivative - Aliphatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as thiolanes. These are organic compounds containing thiolane, a five-member saturated ring containing four carbon atoms and a sulfur atom. |
| External Descriptors | a small molecule |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 J2120529 | Certificate of Analysis | Aug 12, 2025 | T107485 |
| J2120531 | Certificate of Analysis | Aug 12, 2025 | T107485 |
| J2120584 | Certificate of Analysis | Aug 12, 2025 | T107485 |
| G2105055 | Certificate of Analysis | Apr 08, 2025 | T107485 |
| D2415324 | Certificate of Analysis | Mar 22, 2024 | T107485 |
| E2305814 | Certificate of Analysis | Nov 16, 2022 | T107485 |
| F2609078 | Certificate of Analysis | Nov 16, 2022 | T107485 |
| J2523117 | Certificate of Analysis | Nov 16, 2022 | T107485 |
| J2528178 | Certificate of Analysis | Nov 16, 2022 | T107485 |
| L2215076 | Certificate of Analysis | Nov 16, 2022 | T107485 |
| L2215080 | Certificate of Analysis | Nov 16, 2022 | T107485 |
| L2215084 | Certificate of Analysis | Nov 16, 2022 | T107485 |
| L2215121 | Certificate of Analysis | Nov 16, 2022 | T107485 |
| E2305808 | Certificate of Analysis | Oct 08, 2021 | T107485 |
| Solubility | Insoluble in water, soluble in alcohol, ether, acetone, benzene and chloroform. |
|---|---|
| Refractive Index | 1.503-1.505 |
| Flash Point(°F) | 55.4 °F |
| Flash Point(°C) | 13°C |
| Boil Point(°C) | 119°C |
| Melt Point(°C) | -96°C |
| Molecular Weight | 88.170 g/mol |
| XLogP3 | 1.400 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 88.0347 Da |
| Monoisotopic Mass | 88.0347 Da |
| Topological Polar Surface Area | 25.300 Ų |
| Heavy Atom Count | 5 |
| Formal Charge | 0 |
| Complexity | 22.800 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Hao Zhang, Mingyao Wang, Meiyu Qian, Hongquan Wei. (2023) Odor familiarity and improvement of olfactory identification test in Chinese population. Frontiers in Psychology, [PMID:37908819] [10.3389/fpsyg.2023.1278668] |
| 2. Kefan Ouyang, Hexiang Xie, Yufeng Wang, Fangjian Ning, Hua Xiong, Qiang Zhao. (2023) Color formation during the fibrillization of whey protein isolate: Maillard reaction and protein oxidation. FOOD HYDROCOLLOIDS, [PMID:] [10.1016/j.foodhyd.2023.108819] |
| 3. Lei Jiang, Chengkun Wu, Lu Yao, Qiuxia Dong, Guohua Wu. (2023) Effect of CeO2 NPs on stability of regenerated silk fibroin against UV-aging. JOURNAL OF APPLIED POLYMER SCIENCE, 140 (17): (e53788). [PMID:] [10.1002/app.53788] |
| 4. Yefeng Liu, Fei Wang, Ying Lv, Saisai Yu, Ruixin Wang, Weizhou Jiao. (2020) Three-Dimensional Graphene Oxide Covalently Functionalized with Dawson-Type Polyoxotungstates for Oxidative Desulfurization of Model Fuels. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, [PMID:] [10.1021/acs.iecr.0c04384] |
| 5. Yefeng Liu, Peng Zuo, Ruixin Wang, Yaqing Liu, Weizhou Jiao. (2020) Covalent immobilization of Dawson polyoxometalates on hairy particles and its catalytic properties for the oxidation desulfurization of tetrahydrothiophene. Journal of Cleaner Production, [PMID:] [10.1016/j.jclepro.2020.122774] |
| 6. Riyi Lin, Kai Chen, Mingqiang Miao, Liqiang Zhang, Xinwei Wang, Ye Jiang, Jianliang Zhang, Yue Wang, Huida Pan. (2020) Reaction Mechanism of H2S Generation during Tetrahydrothiophene Aquathermolysis Reaction. ENERGY & FUELS, [PMID:] [10.1021/acs.energyfuels.9b03844] |
| 7. Jiajun Gao, Shuang Zhu, Yafen Dai, Chunyan Xiong, Chunxi Li, Weimin Yang, Xingmao Jiang. (2018) Performance and mechanism for extractive desulfurization of fuel oil using modified polyethylene glycol. FUEL, [PMID:] [10.1016/j.fuel.2018.06.101] |
| 8. Yexuan Mao, Lanlan Yu, Mengfan Mao, Chuanguo Ma, Lingbo Qu. (2017) Design and study of lipopeptide inhibitors on preventing aggregation of human islet amyloid polypeptide residues 11-20. JOURNAL OF PEPTIDE SCIENCE, 24 (1): (e3058). [PMID:29159976] [10.1002/psc.3058] |
| 9. Yexuan Mao, Lanlan Yu, Ran Yang, Chuanguo Ma, Ling-bo Qu, Peter de B. Harrington. (2015) New insights into side effect of solvents on the aggregation of human islet amyloid polypeptide 11–20. TALANTA, [PMID:26653463] [10.1016/j.talanta.2015.11.012] |
| 10. Pan Qi, Yongkang Zhang, Ziang Zhang, Xiaobing Li, Cunlan Guo. (2024) Denatured bovine serum albumin particle decorated graphene oxide nanocomposite for ultrasensitive resistive humidity sensing. Materials Advances, [PMID:] [10.1039/D4MA00832D] |
| 11. Daqi Li, Dujie Zhang, Fan Li, Qiaoling Xiang, Yuan Dong, Lizhu Wang. (2024) Fundamental Studies on Fluids-Independent Regenerative Nanocomposite Hydrogels for Fracture Treatments of Conformance Control. ACS Applied Materials & Interfaces, [PMID:39075036] [10.1021/acsami.4c09258] |
| 12. Jing Liu, Weiwei Wu, Fei Peng, Deying Gong, Yi Kang, Yujun Zhang, Congyan Liu, Yuncheng Li, Guoyan Zhao, Feng Qiu, Wensheng Zhang. (2024) Size control of ropivacaine nano/micro-particles by soft-coating with peptide nanosheets for long-acting analgesia. Theranostics, [PMID:38646642] [10.7150/thno.93322] |
| 13. Zhuo Zhang, Mingchen Lv, Jiaxi Xu, Yaping Liu, Jinlong Qin, Zhen Fan, Jianzhong Du. (2025) A Metal-Peptide Framework as a Nanozyme for the Attenuation of Amyloid-β Aggregation and Reactive Oxygen Species. JACS Au, [PMID:41001643] [10.1021/jacsau.5c00721] |
| 14. Jiawei Liu, Tongjia Zhang, Lixin Song, Guangyuan Zhou, Honghua Wang. (2025) Novel reactive phenolphthalein-based polyether ketone, its scale-up preparation and high-efficiency toughening in epoxy resin modification. POLYMER ENGINEERING AND SCIENCE, [PMID:] [10.1002/pen.27247] |
| 15. Dong Han, Guan-Nan Zhang, Zhen-Wen Sun, Yao Liu. (2025) Forensic analysis of tetrahydrothiophene (THT) at gas explosion scenes: Adsorption-desorption dynamics on common substrates. Forensic Chemistry, [PMID:] [10.1016/j.forc.2025.100703] |
| 16. Wang Zhenyu, Yang Yingguo, Luo Guizhong, Xu Wenwu, Liu Chengyu, Yang Tianqi, Ji Wenyu, Zhang Fujun, Lu Min, Zhang Yu, Wu Zhennan, Bai Xue. (2026) Flexible light-emitting diodes with EQE approaching 26.4% from horizontal dipole-oriented metal nanoclusters. Nature Communications, 17 (1): (767). [PMID:41565634] [10.1038/s41467-025-67737-x] |
