4,4-Dihydroxystilbene - ≥95% , CAS No.659-22-3

CAS: 659-22-3 Cat. No.: D331689 Molecular Weight: 212.24 Beilstein Registry Number: 2048565 EC Number: 211-530-9
AVAILABLE TO ORDER
GRADE & PURITY ≥95%
Synonyms
AKOS000278359 | Phenol, 4,4'-(1,2-ethenediyl)bis-, (E)- | EC-000.1580 | Phenol, 4,4'-(1E)-1,2-ethenediylbis- | p,p'-Dihydroxystilbene | 4,4'-Dioxystilbene | 921UXX4IZL | 4,4'-(ethene-1,2-diyl)diphenol | 6DRS5V9W5C | NSC4184 | NSC-4184 | 4,4 inverted excla
Storage
Store at 2-8°C,Argon charged
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
5mg
D331689-5mg
3
$14.90
25mg
D331689-25mg
2
$49.90
100mg
D331689-100mg
2
$129.90
500mg
D331689-500mg
2
$481.90
1g
D331689-1g
2
$910.90
Enter a quantity for the sizes you want to add.
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Why this grade

≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
AKOS000278359 | Phenol, 4, 4'-(1, 2-ethenediyl)bis-, (E)- | EC-000.1580 | Phenol, 4, 4'-(1E)-1, 2-ethenediylbis- | p, p'-Dihydroxystilbene | 4, 4'-Dioxystilbene | 921UXX4IZL | 4, 4'-(ethene-1, 2-diyl)diphenol | 6DRS5V9W5C | NSC4184 | NSC-4184 | 4, 4 inverted excla
Specifications & Purity
≥95%
Storage
Store at 2-8°C, Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥95%
Product Properties
pKapKa: 9.82 (Predicted)
Names and Identifiers
Canonical SmilesC1=CC(=CC=C1C=CC2=CC=C(C=C2)O)O
IUPAC Name4-[(E)-2-(4-hydroxyphenyl)ethenyl]phenol
InChIKeyXLAIWHIOIFKLEO-OWOJBTEDSA-N
INCHI1S/C14H12O2/c15-13-7-3-11(4-8-13)1-2-12-5-9-14(16)10-6-12/h1-10,15-16H/b2-1+
Isomeric SMILES C1=CC(=CC=C1/C=C/C2=CC=C(C=C2)O)O
Molecular Weight 212.24
Beilstein 2048565
Reaxy-Rn 2329460
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2329460&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClassStilbenes
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentStilbenes
Alternative Parents Styrenes  1-hydroxy-2-unsubstituted benzenoids  Organooxygen compounds  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Stilbene - Styrene - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Benzenoid - Monocyclic benzene moiety - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids.
External Descriptors Diphenyl ethers, biphenyls, dibenzyls and stilbenes
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR2 Tclin Estrogen receptor beta (9272 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TRPV1 Tclin Vanilloid receptor (8273 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Caco-2 (12174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
PC-12 (7051 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot NumberCertificate TypeDateItem
I2224220Certificate of AnalysisJul 21, 2025 D331689
I2224207Certificate of AnalysisJul 21, 2025 D331689
I2224206Certificate of AnalysisJul 21, 2025 D331689
I2224184Certificate of AnalysisJul 21, 2025 D331689
I2224175Certificate of AnalysisJul 21, 2025 D331689
C2507201Certificate of AnalysisJun 25, 2022 D331689
Chemical and Physical Properties
SolubilityDMSO (Slightly), Methanol (Slightly)
Refractive Indexn20D1.73 (Predicted)
Boil Point(°C)386.01° C at 760 mmHg (Predicted)
Melt Point(°C)294.5° C
Molecular Weight212.240 g/mol
XLogP33.500
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass212.084 Da
Monoisotopic Mass212.084 Da
Topological Polar Surface Area40.500 Ų
Heavy Atom Count16
Formal Charge0
Complexity197.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds1
Covalently-Bonded Unit Count1
Documents & Articles
Solution Calculators
Reviews

Customer Reviews

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