4-Methyl-2-(1-piperidinyl)-quinoline - Moligand™, ≥98%(HPLC) , Channel blocker of TRPC4;Channel blocker of TRPC5, CAS No.5465-86-1, Channel blocker of TRPC4;Channel blocker of TRPC5

CAS: 5465-86-1 Cat. No.: M134489 Molecular Weight: 226.32 EC Number: 803-730-5

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

GTPL4255 | STL305647 | 4-Methyl-2-(1-piperidinyl)-quinoline;ML204 | A870393 | BDBM77617 | SCHEMBL14975993 | F17389 | 4-methyl-2-piperidin-1-ylquinoline | 4-methyl-2-piperidin-1-yl-quinoline | 4-methyl-2-piperidinoquinoline | 4-methyl-2-piperidino-quinolin

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

GTPL4255 | STL305647 | 4-Methyl-2-(1-piperidinyl)-quinoline;ML204 | A870393 | BDBM77617 | SCHEMBL14975993 | F17389 | 4-methyl-2-piperidin-1-ylquinoline | 4-methyl-2-piperidin-1-yl-quinoline | 4-methyl-2-piperidinoquinoline | 4-methyl-2-piperidino-quinolin

Specifications & Purity

Moligand™, ≥98%(HPLC)

Biochemical and Physiological Mechanisms

Blocker of TRPC4 channels (IC50values are 0.96 and 2.6μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

CHANNEL BLOCKER

Mechanism of action

Channel blocker of TRPC4;Channel blocker of TRPC5

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 504757991
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504757991
• Canonical Smiles: CC1=CC(=NC2=CC=CC=C12)N3CCCCC3
• IUPAC Name: 4-methyl-2-piperidin-1-ylquinoline
• InChIKey: USYRQXDHKXGTCK-UHFFFAOYSA-N
• INCHI: 1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3
• Isomeric SMILES: CC1=CC(=NC2=CC=CC=C12)N3CCCCC3
• WGK Germany: 3
• Molecular Weight: 226.32
• Reaxy-Rn: 476172
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=476172&ln=

Associated Targets(Human)

TRPC4 Tchem Short transient receptor potential channel 4 (2 Activities)

Discover Target: TRPC4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC5 Tchem Short transient receptor potential channel 5 (1 Activities)

Discover Target: TRPC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACHE Tclin Acetylcholinesterase (1 Activities)

Discover Target: ACHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)

Discover Target: GAA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMPD1 Tchem Sphingomyelin phosphodiesterase (13561 Activities)

Discover Target: SMPD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

L3MBTL1 Tchem Lethal(3)malignant brain tumor-like protein 1 (14536 Activities)

Discover Target: L3MBTL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

Discover Target: KDM4E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Luciferin 4-monooxygenase (66902 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trpc4 Short transient receptor potential channel 4 (1615 Activities)

Discover Target: Trpc4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trpc6 Short transient receptor potential channel 6 (57 Activities)

Discover Target: Trpc6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 22.63, Max Conc. mM: 100; Solvent:1eq. HCl, Max Conc. mg/mL: 5.66, Max Conc. mM: 25 with gentle warming
• Molecular Weight: 226.320 g/mol
• XLogP3: 3.900
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 226.147 Da
• Monoisotopic Mass: 226.147 Da
• Topological Polar Surface Area: 16.100 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 247.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Liu Yang, Zeyu Peng, Fanpeng Gong, WenXin Yan, Yi Shi, Hanyi Li, Chang Zhou, Hong Yao, Menglu Yuan, Fan Yu, Lei Feng, Naifu Wan, Guizhu Liu.  (2024)  TRPC4 aggravates hypoxic pulmonary hypertension by promoting pulmonary endothelial cell apoptosis.  FREE RADICAL BIOLOGY AND MEDICINE,      [PMID:38636714] [10.1016/j.freeradbiomed.2024.04.224]