≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.
| Canonical Smiles | CC(=O)N1CCC(CC1)C2=C(C=C(C=C2)C(=O)N=C(N)N)C(F)(F)F.Cl |
|---|---|
| IUPAC Name | 4-(1-acetylpiperidin-4-yl)-N-(diaminomethylidene)-3-(trifluoromethyl)benzamide;hydrochloride |
| InChIKey | SLSZLEROFKLICF-UHFFFAOYSA-N |
| INCHI | 1S/C16H19F3N4O2.ClH/c1-9(24)23-6-4-10(5-7-23)12-3-2-11(14(25)22-15(20)21)8-13(12)16(17,18)19;/h2-3,8,10H,4-7H2,1H3,(H4,20,21,22,25);1H |
| Alternate CAS | 1204329-34-9 |
| PubChem CID | 121513866 |
| Molecular Weight | 356.34(free) |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 K2420285 | Certificate of Analysis | Jul 23, 2024 | B286959 |
| K2420286 | Certificate of Analysis | Jul 23, 2024 | B286959 |
| K2420290 | Certificate of Analysis | Jul 23, 2024 | B286959 |
| K2420293 | Certificate of Analysis | Jul 23, 2024 | B286959 |
| K2420432 | Certificate of Analysis | Jul 23, 2024 | B286959 |
| K2420438 | Certificate of Analysis | Jul 23, 2024 | B286959 |
| K2420439 | Certificate of Analysis | Jul 23, 2024 | B286959 |
| K2420444 | Certificate of Analysis | Jul 23, 2024 | B286959 |
| K2420445 | Certificate of Analysis | Jul 23, 2024 | B286959 |
| Solubility | Solvent:DMSO, Max Conc. mg/mL: 19.64, Max Conc. mM: 50 |
|---|---|
| Sensitivity | Moisture sensitive |
| Molecular Weight | 392.800 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 2 |
| Exact Mass | 392.123 Da |
| Monoisotopic Mass | 392.123 Da |
| Topological Polar Surface Area | 102.000 Ų |
| Heavy Atom Count | 26 |
| Formal Charge | 0 |
| Complexity | 538.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
