CAPS - ≥98.0% , CAS No.1135-40-6

CAS: 1135-40-6 Cat. No.: C105209 Molecular Weight: 221.32 Beilstein Registry Number: 2835588 EC Number: 214-492-1

GRADE & PURITY ≥98.0%

Synonyms

3-CyclohexylaminopropanesulfonicAcid | 3-(Cyclohexylamino)-propane sulfonic acid (CAPS) | CAPS, BioUltra, >=99.0% (TLC) | N-Cyclohexyl-3-aminopropanesulfonic acid | BUFFER CAPS HIGH-PURITY GRADE 1KG | DB02219 | A803066 | SCHEMBL4441928 | 1H-Purine-2,6-dio

Storage

Room temperature

Shipped In

Normal

Overview

pKa (25 °C)   10.4

Used to formulate CAPS buffer, a zwitterionic buffer useful in the range of pH 7.9-11.1. CAPS buffer is widely used in Western and immunoblotting experiments as well as protein sequencing and identification. Used in the electro transfer of proteins to PVDF (sc-3723) or nitrocellulose membranes (sc-3718, sc-3724). The high pH of this buffer makes it useful for the transfer of proteins with a pI > 8.5. and minimal reactivity with enzymes or proteins, minimal salt effects.

Specifications

Synonyms

3-CyclohexylaminopropanesulfonicAcid | 3-(Cyclohexylamino)-propane sulfonic acid (CAPS) | CAPS, BioUltra, >=99.0% (TLC) | N-Cyclohexyl-3-aminopropanesulfonic acid | BUFFER CAPS HIGH-PURITY GRADE 1KG | DB02219 | A803066 | SCHEMBL4441928 | 1H-Purine-2, 6-dio

Specifications & Purity

≥98.0%

Biochemical and Physiological Mechanisms

Widely used as buffer in Western blotting and SDS-PAGE. Working pH range in aqueous solution: 9.7 - 11.1.

Storage

Room temperature

Shipped In

Normal

Purity

≥98.0%

Names and Identifiers

• Canonical Smiles: C1CCC(CC1)NCCCS(=O)(=O)O
• IUPAC Name: 3-(cyclohexylamino)propane-1-sulfonic acid
• InChIKey: PJWWRFATQTVXHA-UHFFFAOYSA-N
• INCHI: 1S/C9H19NO3S/c11-14(12,13)8-4-7-10-9-5-2-1-3-6-9/h9-10H,1-8H2,(H,11,12,13)
• Isomeric SMILES: C1CCC(CC1)NCCCS(=O)(=O)O
• WGK Germany: 3
• RTECS: TZ6395000
• Molecular Weight: 221.32
• Beilstein: 2835588
• Reaxy-Rn: 2835588
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2835588&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Class Organonitrogen compounds
      • Subclass Cyclohexylamines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Class: Organonitrogen compounds
• Subclass: Cyclohexylamines
• Intermediate Tree Nodes: Not available
• Direct Parent: Cyclohexylamines
• Alternative Parents: Sulfonyls Organosulfonic acids Alkanesulfonic acids Dialkylamines Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic homomonocyclic compounds
• Substituents: Cyclohexylamine - Alkanesulfonic acid - Sulfonyl - Organosulfonic acid - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Secondary amine - Secondary aliphatic amine - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Amine - Aliphatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as cyclohexylamines. These are organic compounds containing a cyclohexylamine moiety, which consist of a cyclohexane ring attached to an amine group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Solvent:water, Max Conc. mg/mL: 11.07, Max Conc. mM: 50
• Melt Point(°C): 324°C
• Molecular Weight: 221.320 g/mol
• XLogP3: -1.400
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 221.109 Da
• Monoisotopic Mass: 221.109 Da
• Topological Polar Surface Area: 74.800 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 239.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Shouping Xu, Renchang Zeng, Jiang Cheng, Zhiqi Cai, Xiufang Wen, Pihui Pi.  (2013)  Preparation of antimicrobial polycarboxybetaine-based hydrogels for studies of drug loading and release.  JOURNAL OF APPLIED POLYMER SCIENCE,  131  (3):   [PMID:] [10.1002/app.39839]