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1,10-Phenanthroline Maleimide
CAS: 351870-31-0 PubChem CID: 9961599 Formula: C₁₆H₉N₃O₂ Molecular Weight: 275.26

Solid ≥96%

In Stock Item #: P345281

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IUPAC Name

1-(1,10-phenanthrolin-5-yl)pyrrole-2,5-dione

SMILES

C1=CC2=CC(=C3C=CC=NC3=C2N=C1)N4C(=O)C=CC4=O

InChIKey
IXIRFFCTTLSORQ-UHFFFAOYSA-N

InChI

1S/C16H9N3O2/c20-13-5-6-14(21)19(13)12-9-10-3-1-7-17-15(10)16-11(12)4-2-8-18-16/h1-9H

Synonyms
1-(1,10-PHENANTHROLIN-5-YL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE | DTXSID30433327 | J-019981 | 1-(1,10-phenanthrolin-5-yl...
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N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
CAS: 25952-53-8 EC Number: 247-361-2 Formula: C₈H₁₈CIN₃ Molecular Weight: 191.70

≥98%

In Stock Item #: E106172

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SMILES

CCN=C=NCCCN(C)C.Cl

InChIKey
FPQQSJJWHUJYPU-UHFFFAOYSA-N

InChI

1S/C8H17N3.ClH/c1-4-9-8-10-6-5-7-11(2)3;/h4-7H2,1-3H3;1H

Synonyms
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride | EDCI·HCl | EDAC·HCl | EDC·HCl | 1-Ethyl-3-(3-dimethylam...
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Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite
CAS: 102690-88-0 Formula: C₁₂H₂₂N₃O₂P Molecular Weight: 271.3

Liquid ≥95%

Out of Stock Item #: B165524

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IUPAC Name

3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

SMILES

CC(C)N(C(C)C)P(OCCC#N)OCCC#N

InChIKey
LDHWBEHZLFDXCU-UHFFFAOYSA-N

InChI

1S/C12H22N3O2P/c1-11(2)15(12(3)4)18(16-9-5-7-13)17-10-6-8-14/h11-12H,5-6,9-10H2,1-4H3

Synonyms
bis(2-cyanoethoxy)diisopropylamino-phosphine | LDHWBEHZLFDXCU-UHFFFAOYSA-N | Bis(2-cyanoethyl)-N,N-diisopropylphospho...
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Bis(Triethoxysilylpropyl)Disulfide
CAS: 56706-10-6 Formula: C₁₈H₄₂O₆S₂Si₂ Molecular Weight: 474.83

≥98%

In Stock Item #: B304016

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IUPAC Name

triethoxy-[3-(3-triethoxysilylpropyldisulfanyl)propyl]silane

SMILES

CCO[Si](CCCSSCCC[Si](OCC)(OCC)OCC)(OCC)OCC

InChIKey
FBBATURSCRIBHN-UHFFFAOYSA-N

InChI

1S/C18H42O6S2Si2/c1-7-19-27(20-8-2,21-9-3)17-13-15-25-26-16-14-18-28(22-10-4,23-11-5)24-12-6/h7-18H2,1-6H3

Synonyms
4,4,13,13-Tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane | Bis(triethoxysilylpropyl)disulfide | Bis[3-(Triet...
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5-Ethynyluridine (5-EU)
CAS: 69075-42-9 Formula: C₁₁H₁₂N₂O₆ Molecular Weight: 268.22

≥99%

In Stock Item #: E276476

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IUPAC Name

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-ethynylpyrimidine-2,4-dione

SMILES

C#CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O

InChIKey
QCWBIPKYTBFWHH-FDDDBJFASA-N

InChI

1S/C11H12N2O6/c1-2-5-3-13(11(18)12-9(5)17)10-8(16)7(15)6(4-14)19-10/h1,3,6-8,10,14-16H,4H2,(H,12,17,18)/t6-,7-,8-,10-/m1/s1

Synonyms
5-EU | AKOS024462949 | 5-ethynyl uridine | DS-8002 | EX-A3665 | GLXC-25273 | AC-32359 | QCWBIPKYTBFWHH-FDDDBJFASA-N |...
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2′-Deoxyguanosine hydrate
CAS: 207121-55-9 PubChem CID: 135445705 Formula: C₁₀H₁₃N₅O₄ · xH₂O Molecular Weight: 267.24 (anhydrous basis)

≥99%

In Stock Item #: D168464

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IUPAC Name

2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one;hydrate

SMILES

C1C(C(OC1N2C=NC3=C2N=C(NC3=O)N)CO)O.O

InChIKey
LZSCQUCOIRGCEJ-FPKZOZHISA-N

InChI

1S/C10H13N5O4.H2O/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6;/h3-6,16-17H,1-2H2,(H3,11,13,14,18);1H2/t4-,5+,6+;/m0./s1

Synonyms
LZSCQUCOIRGCEJ-FPKZOZHISA-N | 2`-Deoxyguanosine monohydrate | 2'deoxyguanosine monohydrate | 2'-Deoxyguanosine monohy...
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2′-Deoxyadenosine 5′-monophosphate
CAS: 653-63-4 EC Number: 211-503-1 Formula: C₁₀H₁₄N₅O₆P Molecular Weight: 331.22

Moligand™ ? ≥98%

In Stock Item #: D113455

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Technical Identifiers

IUPAC Name

[(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate

SMILES

C1C(C(OC1N2C=NC3=C(N=CN=C32)N)COP(=O)(O)O)O

InChIKey
KHWCHTKSEGGWEX-RRKCRQDMSA-N

InChI

1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/t5-,6+,7+/m0/s1

Synonyms
2'-deoxyadenosine-5'-monophosphate | 2-Deoxyadenosine-5-monophosphate | MFCD00005753 | Q1874427 | 2'-Deoxy-5'-adenosi...
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Methyl N,N,N′,N′-tetraisopropylphosphorodiamidite
CAS: 92611-10-4 Formula: [[(CH₃)₃CH]₂N]₂POCH₃ Molecular Weight: 262.37

≥96%

In Stock Item #: M330939

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IUPAC Name

N-[[di(propan-2-yl)amino]-methoxyphosphanyl]-N-propan-2-ylpropan-2-amine

SMILES

CC(C)N(C(C)C)P(N(C(C)C)C(C)C)OC

InChIKey
YFYBXOIQXOOUCI-UHFFFAOYSA-N

InChI

1S/C13H31N2OP/c1-10(2)14(11(3)4)17(16-9)15(12(5)6)13(7)8/h10-13H,1-9H3

Synonyms
bis(diisopropylamino) methoxyphosphine | AKOS024375420 | N,N,N',N'-Tetraisopropyl-1-methoxyphosphanediamine | Methyl ...
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2′-Deoxyadenosine 5′-monophosphate
CAS: 653-63-4 EC Number: 211-503-1 Formula: C₁₀H₁₄N₅O₆P Molecular Weight: 331.22

Moligand™ ? 10mM in DMSO

In Stock Item #: D425305

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IUPAC Name

[(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate

SMILES

C1C(C(OC1N2C=NC3=C(N=CN=C32)N)COP(=O)(O)O)O

InChIKey
KHWCHTKSEGGWEX-RRKCRQDMSA-N

InChI

1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/t5-,6+,7+/m0/s1

Synonyms
2'-deoxyadenosine-5'-monophosphate | 2-Deoxyadenosine-5-monophosphate | MFCD00005753 | Q1874427 | 2'-Deoxy-5'-adenosi...
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iPr2N-P-(OTSE)2
CAS: 121373-20-4 Formula: C₁₆H₄₀NO₂PSi₂ Molecular Weight: 365.65

Out of Stock Item #: I341280

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IUPAC Name

N-[bis(2-trimethylsilylethoxy)phosphanyl]-N-propan-2-ylpropan-2-amine

SMILES

CC(C)N(C(C)C)P(OCC[Si](C)(C)C)OCC[Si](C)(C)C

InChIKey
UCVPTNNSVPPRRA-UHFFFAOYSA-N

InChI

1S/C16H40NO2PSi2/c1-15(2)17(16(3)4)20(18-11-13-21(5,6)7)19-12-14-22(8,9)10/h15-16H,11-14H2,1-10H3

Synonyms
bis(2-trimethylsilylethoxy)(diisopropylamino)pho sphane | FT-0757197 | N-[bis(2-trimethylsilylethoxy)phosphanyl]-N-pr...
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(2′S)-2′-Deoxy-2′-fluoro-5-ethynyluridine (F-ara-EdU)
CAS: 95740-26-4 PubChem CID: 514810 Formula: C₁₁H₁₁FN₂O₅ Molecular Weight: 270.21

≥95%

In Stock Item #: S479901

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IUPAC Name

5-ethynyl-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

SMILES

C#CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)F

InChIKey
YEEGMPUOCRQFRV-IBCQBUCCSA-N

InChI

1S/C11H11FN2O5/c1-2-5-3-14(11(18)13-9(5)17)10-7(12)8(16)6(4-15)19-10/h1,3,6-8,10,15-16H,4H2,(H,13,17,18)/t6-,7+,8-,10-/m1/s1

Synonyms
5-ethynyl-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione | Q27460255 | 1-(2-De...
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γ-[(Propargyl)-imido]-ATP sodium salt
Formula: C₁₃H₁₉N₆O₁₂P₃ · xNa+ Molecular Weight: 544.24 (free acid basis)

Solid ≥95%

In Stock Item #: P487786

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Synonyms
Adenosine-5’-[γ-(propargyl)-imido]triphosphate, Sodium salt | Adenosine-5’-[γ-(propargyl)-imido]triphosphate sodium salt

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Frequently Asked Questions

How do I choose between Coupling Reagents variants?

Match reagent to substrate compatibility, required selectivity, scalability, and downstream purification needs. Different coupling reagents have distinct reactivity profiles — review reaction conditions and reported yields for each variant.

What specifications matter for Coupling Reagents?

Purity, titer (for solution reagents), water content for moisture-sensitive reagents, stabilizer presence, and pack size. Always check certificate of analysis for batch-specific quality data.

How should Coupling Reagents be stored and handled?

Many synthesis reagents are moisture- or air-sensitive. Store in sealed containers under inert atmosphere when specified. Solution reagents may degrade after multiple openings — aliquot for long-term storage.

Are research and process scales both available?

Yes. Coupling Reagents are available in gram-scale research quantities through kilogram-scale process supplies. Bulk packaging and custom synthesis options are available on request.

Coupling reagents are commonly used to activate functional groups for amide formation, esterification, peptide synthesis, and other bond-forming reactions. Researchers usually compare activation strength, byproduct profile, racemization risk, solvent compatibility, substrate sensitivity, and ease of workup during reagent selection. This page supports method development when several activation systems need to be screened for efficiency and cleanliness. It pairs naturally with peptide-synthesis, protection, and bioconjugation-related workflows.