Emtricitabine (BW 1592) - Moligand™, 10mM in DMSO , Human immunodeficiency virus type 1 reverse transcriptase inhibitor, CAS No.143491-57-0, Human immunodeficiency virus type 1 reverse transcriptase inhibitor

CAS: 143491-57-0 Cat. No.: E408866 Fórmula: C₈H₁₀FN₃O₃S Peso molecular: 247.25 Número EC: 604-363-1

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

FTC | 4-​amino-​5-​fluoro-​1-​[(2R,​5S)​-​2-​(hydroxymethyl)​-​1,​3-​oxathiolan-​5-​yl]​-2(1H)​-​pyrimidinone

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Emtricitabine (BW 1592) Emtricitabine (BW1592, FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.
In vitro

Emtricitabine moderately reduces hepatocyte proliferation independent of effects on mtDNA in HepG2 human hepatoma cells. Emtricitabine plus tenofovir slightly reduced cell proliferation without affecting mitochondrial parameters. Emtricitabine efficiently converts to their active metabolites in PBMCs and CEM cells. Emtricitabine combined with Tenofovir displays additive to synergistic activity against HIV replication in PBMCs and results in strongly synergistic anti-HIV activity in MT-2 cells against both wild-type and mutant virus. Emtricitabine demonstrates antiviral activity against laboratory adapted strains of HIV-1 and HIV-2 in various cell system. Emtricitabine also exhibits antiviral activity in cell culture against feline and simian immuno-deficiency viruses (SIVs). Emtricitabine consistently exhibits up to 10-fold greater activity than lamivudine against all viruses tested in all T-cell lines. Emtricitabine generally demonstrates greater potency in vitro in human PBMCs than in MT-4 lines. Emtricitabine also exhibits anti-HBV activity in vitro (EC50, 0.01–0.04 µM) that is comparable to the anti-HBV activity of 3TC. Emtricitabine is approximately fourfold more active than 3TC in assays in the transformed T-cell line MT-4 infected with HIV-(1IIIB), whereas Zidovudine is more active than Emtricitabine. Emtricitabine, Lamivudine and Zidovudine are equally active against a panel of eight primary HIV-1 isolates from antiretroviral-naive subjects in PBMCs.

In vivo

Cell Data

cell lines：Erythroid cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

FTC | 4-​amino-​5-​fluoro-​1-​[(2R,​5S)​-​2-​(hydroxymethyl)​-​1,​3-​oxathiolan-​5-​yl]​-2(1H)​-​pyrimidinone

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Emtricitabine (BW1592, FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Human immunodeficiency virus type 1 reverse transcriptase inhibitor

Nombres e identificadores

• Isómeros SMILES: C1[C@H](O[C@H](S1)CO)N2C=C(C(=NC2=O)N)F
• Peso molecular: 247.25
• Reaxy-Rn: 11732976
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11732976&ln=

Propiedades químicas y físicas

• Rotación específica [α]: -140° (C=0.25,MeOH)
• Punto de fusión (°C): 155 °C