Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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224,000+ research products · Triple ISO certified · COA & SDS available for every product · Same-day shipping on in-stock items
Why this grade
Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
Specifications
Synonyms
compound 13;GNE 131;GNE131
Specifications & Purity
Moligand™, ≥98%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of Na v1.1;Inhibitor of Na v1.2;Inhibitor of Na v1.5;Inhibitor of Na v1.6;Inhibitor of Na v1.7
Purity
≥98%
Names and Identifiers
| Canonical Smiles | C1CC1C2=CN3C(=NN=C3NS(=O)(=O)C4CC4)C=C2OCC56CC7CC(C5)CC(C7)C6 |
|---|---|
| IUPAC Name | N-[7-(1-adamantylmethoxy)-6-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl]cyclopropanesulfonamide |
| InChIKey | FPERPEQIXLOVIK-UHFFFAOYSA-N |
| INCHI | 1S/C23H30N4O3S/c28-31(29,18-3-4-18)26-22-25-24-21-8-20(19(12-27(21)22)17-1-2-17)30-13-23-9-14-5-15(10-23)7-16(6-14)11-23/h8,12,14-18H,1-7,9-11,13H2,(H,25,26) |
| Isomeric SMILES | C1CC1C2=CN3C(=NN=C3NS(=O)(=O)C4CC4)C=C2OCC56CC7CC(C5)CC(C7)C6 |
| PubChem CID | 91666633 |
| Molecular Weight | 442.57 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Taxonomic Classification
Taxonomy Tree
- Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
- Class Triazolopyridines
- Superclass Organoheterocyclic compounds
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Triazolopyridines |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Triazolopyridines |
| Alternative Parents | Alkyl aryl ethers Pyridines and derivatives Organosulfonamides Organic sulfonamides Triazoles Heteroaromatic compounds Aminosulfonyl compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Triazolopyridine - Alkyl aryl ether - Organosulfonic acid amide - Organic sulfonic acid amide - Pyridine - Heteroaromatic compound - Aminosulfonyl compound - 1,2,4-triazole - Triazole - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Azole - Azacycle - Ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as triazolopyridines. These are compounds containing a triazole ring fused to a pyridine ring. Triazole is a five-membered ring consisting of two carbon atoms and three nitrogen atoms. Pyridine is a 6-membered ring consisting of five carbon atoms and one nitrogen center. |
| External Descriptors | Not available |
3D Structure
Interactive Chemical Structure Model
Associated Targets(Human)
SCN2A Tclin Sodium channel protein type 2 subunit alpha (2 Activities)
SCN5A Tclin Sodium channel protein type 5 subunit alpha (2 Activities)
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SCN9A Tclin Sodium channel protein type 9 subunit alpha (5 Activities)
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SCN1A Tclin Sodium channel protein type 1 subunit alpha (2 Activities)
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SCN8A Tclin Sodium channel protein type 8 subunit alpha (2 Activities)
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SCN1A Tclin Sodium channel protein type I alpha subunit (483 Activities)
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KCNH2 Tclin HERG (29587 Activities)
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CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
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SCN5A Tclin Sodium channel protein type V alpha subunit (3462 Activities)
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NR1I2 Tchem Pregnane X receptor (6667 Activities)
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CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
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CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
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U2OS (164939 Activities)
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Associated Targets(non-human)
Scn2a Sodium channel protein type II alpha subunit (191 Activities)
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Scn9a Sodium channel protein type IX alpha subunit (69 Activities)
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Scn8a Sodium channel protein type VIII alpha subunit (53 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Canis familiaris (36305 Activities)
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Mus musculus (284745 Activities)
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Rattus norvegicus (775804 Activities)
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Scn9a Sodium channel protein type 9 subunit alpha (111 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanisms of Action
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 H2423257 | Certificate of Analysis | May 13, 2024 | G610612 |
| H2423258 | Certificate of Analysis | May 13, 2024 | G610612 |
| H2423259 | Certificate of Analysis | May 13, 2024 | G610612 |
| H2423260 | Certificate of Analysis | May 13, 2024 | G610612 |
| H2423261 | Certificate of Analysis | May 13, 2024 | G610612 |
| H2423262 | Certificate of Analysis | May 13, 2024 | G610612 |
| H2423263 | Certificate of Analysis | May 13, 2024 | G610612 |
| H2423264 | Certificate of Analysis | May 13, 2024 | G610612 |
Chemical and Physical Properties
| Molecular Weight | 442.600 g/mol |
|---|---|
| XLogP3 | 4.800 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 7 |
| Exact Mass | 442.204 Da |
| Monoisotopic Mass | 442.204 Da |
| Topological Polar Surface Area | 94.000 Ų |
| Heavy Atom Count | 31 |
| Formal Charge | 0 |
| Complexity | 780.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
Solution Calculators
Reviews
Customer Reviews
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