Raclopride - Moligand™, ≥95% , Antagonist of 5-HT 1A receptor;Antagonist of D 2 receptor;Antagonist of D 3 receptor;Antagonist of D 4 receptor, CAS No.84225-95-6, Antagonist of 5-HT 1A receptor;Antagonist of D 2 receptor;Antagonist of D 3 receptor;Antagonist of D 4 receptor

CAS: 84225-95-6 Cat. No.: R160944 Molecular Weight: 347.24 PubChem CID: 3033769

GRADE & PURITY Moligand™, ≥95%

Synonyms

(S)-3,5-DICHLORO-N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-2-HYDROXY-6-METHOXYBENZAMIDE | (S)-3,5-Dichloro-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-hydroxy-6-methoxybenzamide | FLA 870 | MLS001423957 | 3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-metho

Storage

Room temperature

Shipped In

Normal

Specifications

Synonyms

(S)-3, 5-DICHLORO-N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-2-HYDROXY-6-METHOXYBENZAMIDE | (S)-3, 5-Dichloro-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-hydroxy-6-methoxybenzamide | FLA 870 | MLS001423957 | 3, 5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-metho

Specifications & Purity

Moligand™, ≥95%

Biochemical and Physiological Mechanisms

High affinity (K d = 1.2 nM) and high selectivity for D 2 receptors in vitro and in vivo (IC 50 = 32 nM). Centrally active following systemic administration.

Storage

Room temperature

Shipped In

Normal

Grade

Moligand™

Action Type

ANTAGONIST

Mechanism of action

Antagonist of 5-HT 1A receptor;Antagonist of D 2 receptor;Antagonist of D 3 receptor;Antagonist of D 4 receptor

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥95%

Names and Identifiers

• Pubchem Sid: 504762345
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504762345
• Canonical Smiles: CCN1CCCC1CNC(=O)C2=C(C(=CC(=C2OC)Cl)Cl)O
• IUPAC Name: 3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide
• InChIKey: WAOQONBSWFLFPE-VIFPVBQESA-N
• INCHI: 1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1
• Isomeric SMILES: CCN1CCC[C@H]1CNC(=O)C2=C(C(=CC(=C2OC)Cl)Cl)O
• RTECS: CV3463500
• Alternate CAS: 84225-95-6
• PubChem CID: 3033769
• MeSH Entry Terms: C11, Raclopride;FLA 870;FLA-870;FLA870;FLB 472;FLB-472;FLB472;Raclopride;Raclopride C11
• Molecular Weight: 347.24
• Reaxy-Rn: 3559819

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Benzoic acids and derivatives
        • Level5 Hydroxybenzoic acid derivatives
          • Level6 Salicylic acid and derivatives
            • Level7 Salicylamides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Benzoic acids and derivatives
• Intermediate Tree Nodes: Hydroxybenzoic acid derivatives - Salicylic acid and derivatives
• Direct Parent: Salicylamides
• Alternative Parents: Methoxyphenols 3-halobenzoic acids and derivatives Benzamides Benzoyl derivatives Dichlorobenzenes Anisoles Methoxybenzenes O-chlorophenols P-chlorophenols Phenoxy compounds Alkyl aryl ethers N-alkylpyrrolidines Aryl chlorides Vinylogous acids Amino acids and derivatives Secondary carboxylic acid amides Trialkylamines Azacyclic compounds Hydrocarbon derivatives Organic oxides Organochlorides Organopnictogen compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Salicylamide - Methoxyphenol - 3-halobenzoic acid or derivatives - Halobenzoic acid or derivatives - Benzamide - Phenol ether - 4-chlorophenol - 2-chlorophenol - Phenoxy compound - 1,3-dichlorobenzene - Methoxybenzene - 4-halophenol - 2-halophenol - Benzoyl - Anisole - Halobenzene - Alkyl aryl ether - Phenol - Chlorobenzene - Aryl chloride - Aryl halide - N-alkylpyrrolidine - Pyrrolidine - Vinylogous acid - Secondary carboxylic acid amide - Carboxamide group - Tertiary amine - Tertiary aliphatic amine - Amino acid or derivatives - Organoheterocyclic compound - Ether - Azacycle - Carboxylic acid derivative - Organonitrogen compound - Hydrocarbon derivative - Organohalogen compound - Organic oxide - Organopnictogen compound - Amine - Organic nitrogen compound - Organic oxygen compound - Organooxygen compound - Organochloride - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as salicylamides. These are carboxamide derivatives of salicylic acid. Salicylic acid is the ortho-hydroxylated derivative of benzoic acid.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

DRD2 Tclin D(2) dopamine receptor (9 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD4 Tchem D(4) dopamine receptor (1 Activities)

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DRD3 Tclin D(3) dopamine receptor (6 Activities)

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HTR1A Tclin 5-hydroxytryptamine receptor 1A (1 Activities)

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DRD2 Tclin Dopamine D2 receptor (23596 Activities)

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DRD1 Tclin Dopamine D1 receptor (9720 Activities)

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DRD4 Tchem Dopamine D4 receptor (7907 Activities)

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DRD3 Tclin Dopamine D3 receptor (14368 Activities)

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ARSA Tbio Cerebroside-sulfatase (655 Activities)

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CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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Caco-2 (12174 Activities)

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HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

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KMT2A Tchem Histone-lysine N-methyltransferase MLL (17327 Activities)

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GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)

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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

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Galc Galactocerebrosidase (11 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Rattus norvegicus (775804 Activities)

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lef Anthrax lethal factor (7585 Activities)

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Luciferin 4-monooxygenase (66902 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Brain (1 Activities)

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Plasma (328 Activities)

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fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

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Drd5 Dopamine receptor (1304 Activities)

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in Methanol
• Sensitivity: Air Sensitive
• Specific Rotation[α]: -70° (C=2,Acetone)
• Melt Point(°C): 54 °C
• Molecular Weight: 347.200 g/mol
• XLogP3: 2.900
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 346.085 Da
• Monoisotopic Mass: 346.085 Da
• Topological Polar Surface Area: 61.800 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 386.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Jinxin Yu, Jiayi He, Xin Gong, Jimin Xu, Yongqiang Bai, Yiqiang Tian, Xilian Yang, Xinnian Zeng, Jiali Liu.  (2025)  The role of dopamine signaling in olfactory associative learning and memory in the oriental fruit fly, Bactrocera dorsalis.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:41326102] [10.1016/j.pestbp.2025.106740]