GRADE & PURITYAnimal Free?Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material.Carrier Free?Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays.Bioactive?Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure.ActiBioPure™?ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required.Azide Free?Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory.High Performance?High-performance grade with optimized purity and performance characteristics. Use for sensitive analyses where ordinary grades fall short.Fc tag?Fc tag grade — recombinant protein bearing a Fc tag for affinity purification/detection. Use to purify, immobilize, or detect the tagged protein. The Fc tag aids dimerization and protein-A/G capture.≥95%(SDS-PAGE)
Expression System
HEK293
Accession #
O35235
Protein Tag
N-Met & Fc
Expression system
HEK293
Endotoxin Concentration
<0.01 EU/μg
Bioactivity
Measured by its ability to induce TRAP activity in Raw 264.7 cells.The ED50 of each lot is between 2-10 ng/mL.
Store at -20°C,Avoid repeated freezing and thawing Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Purity
＞95% SDS-PAGE.
Actual molecular weight
19 kDa
Additional sequence information
Soluble Receptor Activator of NFkB Ligand
Function
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
Post-translational
The soluble form of isoform 1 derives from the membrane form by proteolytic processing (By similarity). The cleavage may be catalyzed by ADAM17.
Reconstitute in water to a concentration of 0.1-1.0 mg/ml
Storage
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -20~-80℃ for more than 1 year.
Images
Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein (rp154577) - Protein Bioactivity Measured by its ability to induce TRAP activity in Raw 264.7 cells. The ED₅₀ of this effect is 7.0 ng/mL.
Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein (rp154577) - SDS-PAGE 2.5 μg/lane of Recombinant Mouse TRANCE/RANK L/TNFSF11 was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 57.4 kDa under reducing condition and 114.0 kDa under non-reducing condition.
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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