Determine the necessary mass, volume, or concentration for preparing a solution.
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≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 9 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Venlafaxine hydrochloride is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI).
An inhibitor of ST and SLC6A2.
| Pubchem Sid | 504753893 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504753893 |
| Canonical Smiles | CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl |
| IUPAC Name | 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol;hydrochloride |
| InChIKey | QYRYFNHXARDNFZ-UHFFFAOYSA-N |
| INCHI | 1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H |
| Isomeric SMILES | CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl |
| WGK Germany | 3 |
| RTECS | GV8872760 |
| Alternate CAS | 93413-69-5 |
| PubChem CID | 62923 |
| Molecular Weight | 313.86 |
| Reaxy-Rn | 4240401 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Phenol ethers |
| Subclass | Anisoles |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Anisoles |
| Alternative Parents | Phenoxy compounds Methoxybenzenes Cyclohexanols Aralkylamines Alkyl aryl ethers Tertiary alcohols 1,3-aminoalcohols Trialkylamines Cyclic alcohols and derivatives Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Phenoxy compound - Anisole - Methoxybenzene - Alkyl aryl ether - Aralkylamine - Cyclohexanol - Monocyclic benzene moiety - 1,3-aminoalcohol - Cyclic alcohol - Tertiary alcohol - Tertiary aliphatic amine - Tertiary amine - Ether - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Hydrochloride - Hydrocarbon derivative - Organopnictogen compound - Amine - Organic oxygen compound - Alcohol - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof. |
| External Descriptors | hydrochloride |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jun 13, 2026 | V129637 | |
| Certificate of Analysis | Mar 11, 2026 | V129637 | |
| Certificate of Analysis | Mar 11, 2026 | V129637 | |
| Certificate of Analysis | Mar 11, 2026 | V129637 | |
| Certificate of Analysis | Mar 11, 2026 | V129637 | |
| Certificate of Analysis | Jan 29, 2026 | V129637 | |
| Certificate of Analysis | Jan 29, 2026 | V129637 | |
| Certificate of Analysis | Jul 13, 2024 | V129637 | |
| Certificate of Analysis | Jul 13, 2024 | V129637 | |
| Certificate of Analysis | Jul 06, 2022 | V129637 |
| Solubility | Soluble in water (>25 mg/ml), and DMSO (50 mM) |
|---|---|
| Sensitivity | Light sensitive |
| Melt Point(°C) | 217°C |
| Molecular Weight | 313.900 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 5 |
| Exact Mass | 313.181 Da |
| Monoisotopic Mass | 313.181 Da |
| Topological Polar Surface Area | 32.700 Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 279.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
| 1. Niu Ting, Wei Zhiying, Fu Jiao, Chen Shu, Wang Ru, Wang Yuya, Zheng Ruihe. (2023) Venlafaxine, an anti-depressant drug, induces apoptosis in MV3 human melanoma cells through JNK1/2-Nur77 signaling pathway. Frontiers in Pharmacology, [PMID:36686679] [10.3389/fphar.2022.1080412] |
| 2. Haibo You, Ben Chen, Liqun Fang, Tingting Lin, Ping Xu, Chu Chu, Shengqiang Tong. (2022) Analytical enantioseparation of N-alkyl drugs by reversed-phase liquid chromatography with carboxymethyl-β-cyclodextrin as mobile phase additive. CHIRALITY, 35 (1): (58-66). [PMID:36345792] [10.1002/chir.23516] |
| 3. Jun Luo, Yuxuan Dai, Xiaoming Xu, Yazi Liu, Shaogui Yang, Huan He, Cheng Sun, Qiming Xian. (2021) Green and efficient synthesis of Co-MOF-based/g-C3N4 composite catalysts to activate peroxymonosulfate for degradation of the antidepressant venlafaxine. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:34922080] [10.1016/j.jcis.2021.11.162] |
| 4. Lisha Jin, Sisi Zhou, Shujie Zhu, Shaowei Lei, Weijuan Du, Huidi Jiang, Su Zeng, Hui Zhou. (2019) Dehydrocorydaline induced antidepressant-like effect in a chronic unpredictable mild stress mouse model via inhibiting uptake-2 monoamine transporters. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:31604070] [10.1016/j.ejphar.2019.172725] |
| 5. Xuesong Liu, Liuliu Cheng, Yehong Han, Mingyu Wang, Hongyuan Yan. (2024) Development of a novel second-generation polyester dendritic functionalized graphene oxide for efficient pipette tip micro solid-phase extraction and detection of venlafaxine and desvenlafaxine in urine. JOURNAL OF CHROMATOGRAPHY A, [PMID:39647375] [10.1016/j.chroma.2024.465582] |
| 6. Bo Zhao, Guojing Yang, Zhouyun Xie, Ni Zhang, Jingfen Xia, Xuran Liu, Dongbo Wang, Peier Wang, Li Tang. (2024) Efficient degradation of venlafaxine using intimately coupled high-active crystal facets exposed TiO2 and biodegradation system: Kinetic studies, biofilm stress behavior and transformation mechanism. JOURNAL OF ENVIRONMENTAL MANAGEMENT, [PMID:38759549] [10.1016/j.jenvman.2024.121159] |
| 7. Bin Wang, Yongyue Chen, Wenxuan Li, Yuwei Liu, Xudong Xia, Xia Xu, Yongli Yang, Di Chen. (2024) Magnetic phytic acid-modified kapok fiber biochar as a novel sorbent for magnetic solid-phase extraction of antidepressants in biofluids. ANALYTICA CHIMICA ACTA, [PMID:38401926] [10.1016/j.aca.2024.342295] |
| 8. Yumei Gan, Linlin Hua, Yuanyuan Zheng, Bin Wang, Di Chen. (2024) Natural kapok fiber as a green and efficient adsorbent for in-syringe solid-phase extraction in the determination of antidepressants in biofluids. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2024.110638] |
| 9. Zhanwu Li, Bowen Deng, Jiajia Chen, Ru Feng, Shuling Wang, Shu Li, Di Chen, Linlin Hua. (2025) One-pot synthesis of magnetic adsorbent with integrated pH regulation for convenient and rapid determination of antidepressant in biofluids. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2025.112834] |