2-Thiophenecarboxaldehyde - ≥98% , CAS No.98-03-3

CAS: 98-03-3 Cat. No.: T107122 Molecular Weight: 112.15 Beilstein Registry Number: 105819 EC Number: 202-629-8 PubChem CID: 7364
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
.alpha.-Formylthiophene | thiophene 2-carbaldehyde | thiophenealdehyde | W-100098 | CHEBI:87301 | thien-2-carbaldehyde | Thiophene-2-aldehyde | 2-FORMYLTHIOFURAN | W-204260 | alpha-Thiophenecarboxaldehyde | AC-4923 | alpha-Formylthiophene | STL194296 | Th
Storage
Store at 2-8°C,Argon charged
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
25ml
T107122-25ml
7
$9.90
100ml
T107122-100ml
8
$21.90
500ml
T107122-500ml
1
$87.90
Enter a quantity for the sizes you want to add.
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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 24 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
.alpha.-Formylthiophene | thiophene 2-carbaldehyde | thiophenealdehyde | W-100098 | CHEBI:87301 | thien-2-carbaldehyde | Thiophene-2-aldehyde | 2-FORMYLTHIOFURAN | W-204260 | alpha-Thiophenecarboxaldehyde | AC-4923 | alpha-Formylthiophene | STL194296 | Th
Specifications & Purity
≥98%
Storage
Store at 2-8°C, Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Names and Identifiers
Pubchem Sid504751318
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504751318
Canonical SmilesC1=CSC(=C1)C=O
IUPAC Namethiophene-2-carbaldehyde
InChIKeyCNUDBTRUORMMPA-UHFFFAOYSA-N
INCHI1S/C5H4OS/c6-4-5-2-1-3-7-5/h1-4H
Isomeric SMILES C1=CSC(=C1)C=O
WGK Germany 3
RTECS XM8135000
PubChem CID 7364
Molecular Weight 112.15
Beilstein 105819
Reaxy-Rn 105819

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic oxygen compounds
ClassOrganooxygen compounds
SubclassCarbonyl compounds
Intermediate Tree Nodes Aldehydes
Direct ParentAryl-aldehydes
Alternative Parents Thiophenes  Heteroaromatic compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Aryl-aldehyde - Heteroaromatic compound - Thiophene - Organoheterocyclic compound - Organic oxide - Hydrocarbon derivative - Aromatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as aryl-aldehydes. These are compounds containing an aldehyde group directly attached to an aromatic ring.
External Descriptors thiophenes - aldehyde
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
SLC6A1 Tclin GABA transporter 1 (308 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MPO Tchem Myeloperoxidase (1002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
SARS coronavirus 3C-like proteinase (333 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania infantum (5912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania amazonensis (3813 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Meloidogyne incognita (862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

16 results found

Lot NumberCertificate TypeDateItem
E2627100Certificate of AnalysisJun 05, 2026 T107122
I2525043Certificate of AnalysisSep 30, 2025 T107122
L2109030Certificate of AnalysisAug 11, 2025 T107122
L2109032Certificate of AnalysisAug 11, 2025 T107122
C23241616Certificate of AnalysisDec 19, 2024 T107122
C23241434Certificate of AnalysisDec 19, 2024 T107122
C23241339Certificate of AnalysisDec 10, 2024 T107122
C23241430Certificate of AnalysisDec 10, 2024 T107122
C23241604Certificate of AnalysisDec 10, 2024 T107122
C23241617Certificate of AnalysisDec 10, 2024 T107122
D2503461Certificate of AnalysisJul 12, 2024 T107122
D2503462Certificate of AnalysisJul 12, 2024 T107122
H2520029Certificate of AnalysisJul 12, 2024 T107122
L2109028Certificate of AnalysisSep 13, 2023 T107122
B1808003Certificate of AnalysisJun 13, 2023 T107122
C2111132Certificate of AnalysisDec 13, 2022 T107122

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Chemical and Physical Properties
SolubilityMiscible with chloroform, alcohol, ether, dimethylsulfoxide, ethyl acetate and most organic solvents. Immiscible with water.
SensitivityAir sensitive;Heat sensitive
Refractive Index1.592
Flash Point(°F)170.6 °F
Flash Point(°C)77℃
Boil Point(°C)198°C
Molecular Weight112.150 g/mol
XLogP31.000
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass111.998 Da
Monoisotopic Mass111.998 Da
Topological Polar Surface Area45.300 Ų
Heavy Atom Count7
Formal Charge0
Complexity72.500
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
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2. Tong Zhou, Xue Xia, Heping Cui, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2023)  Promotion or Inhibition Effects of Exogenous Glutathione-Degraded Amino Acids on the Formation of 2,3-Butanedione and Pyrazines via Varied Pathways of Interaction with α-Dicarbonyl Compounds Derived from N-(1-Deoxy-d-xylulos-1-yl)-alanine.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:37737140] [10.1021/acs.jafc.3c04424]
3. Xing Chenyu, Chen Gaoyu, Zhu Xia, An Jiakun, Bao Jianchun, Wang Xuan, Zhou Xiuqing, Du Xiuli, Xu Xiangxing.  (2023)  Synthesis of carbon dots with predictable photoluminescence by the aid of machine learning.  Nano Research,      [PMID:] [10.1007/s12274-023-5893-6]
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5. Tong Zhou, Xue Xia, Heping Cui, Yun Zhai, Foxin Zhang, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2023)  Cysteine-Induced pH-Dependent Formation of Thiols and Sulfides or 2-Acetylthiazole and Pyrazines during Thermal Treatment of N-(1-Deoxy-d-xylulos-1-yl)-alanine.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:36696632] [10.1021/acs.jafc.2c08360]
6. Taotao Li, Xinyi Li, Yu Zheng, Pan Zhu, Cheng Zhang, Kui Zhang, Jing-Juan Xu.  (2023)  Phosphorescent Carbon Dots as Long-Lived Donors To Develop an Energy Transfer-Based Sensing Platform.  ANALYTICAL CHEMISTRY,      [PMID:36652380] [10.1021/acs.analchem.2c04639]
7. Tong Zhou, Xue Xia, Heping Cui, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Competitive Formation of 2,3-Butanedione and Pyrazines through Intervention of Added Cysteine during Thermal Processing of Alanine-Xylose Amadori Compounds.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:36444759] [10.1021/acs.jafc.2c07026]
8. Linhui Feng, Heping Cui, Pusen Chen, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho.  (2022)  Promoted Formation of Pyrazines and Sulfur-Containing Volatile Compounds through Interaction of Extra-Added Glutathione or Its Constituent Amino Acids and Secondary Products of Thermally Degraded N-(1-Deoxy-d-ribulos-1-yl)-Glutathione.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:35838405] [10.1021/acs.jafc.2c02949]
9. Brian Musikavanhu, Yujie Zhang, Dongwei Zhu, Zhaoli Xue, Rui Yuan, Shengjun Wang, Long Zhao.  (2022)  Turn-off detection of Cr(III) with chelation enhanced fluorescence quenching effect by a naphthyl hydrazone Shiff base chemosensor.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:35816866] [10.1016/j.saa.2022.121599]
10. Brian Musikavanhu, Selvaraj Muthusamy, Dongwei Zhu, Zhaoli Xue, Qian Yu, Choonzo N. Chiyumba, John Mack, Tebello Nyokong, Shengjun Wang, Long Zhao.  (2021)  A simple quinoline-thiophene Schiff base turn-off chemosensor for Hg2+ detection: spectroscopy, sensing properties and applications.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:34482149] [10.1016/j.saa.2021.120338]
11. Shichao Xu, Xiaojing Zeng, Songlin Dai, Jing Wang, Yuxiang Chen, Jie Song, Yunfei Shi, Xian Cheng, Shengliang Liao, Zhendong Zhao.  (2020)  Turpentine Derived Secondary Amines for Sustainable Crop Protection: Synthesis, Activity Evaluation and QSAR Study.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:32975941] [10.1021/acs.jafc.0c01909]
12. Tianhao Jiang, Chaoqun Shang, Qingguo Meng, Mingliang Jin, Hua Liao, Ming Li, Zhihong Chen, Mingzhe Yuan, Xin Wang, Guofu Zhou.  (2018)  The Ternary Heterostructures of BiOBr/Ultrathin g-C3N4/Black Phosphorous Quantum Dot Composites for Photodegradation of Tetracycline.  Polymers,  10  (10): (1118).  [PMID:30961042] [10.3390/polym10101118]
13. Haoping Wang, Tiantian Kang, Xiaoju Wang, Liheng Feng.  (2018)  Design and synthesis of a novel tripod rhodamine derivative for trivalent metal ions detection.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2018.03.003]
14. Yusha Feng, Ziyu Kuai, Yan Song, Jing Guo, Qingbiao Yang, Yaming Shan, Yaoxian Li.  (2017)  A novel “turn-on” thiooxofluorescein-based colorimetric and fluorescent sensor for Hg2+ and its application in living cells.  TALANTA,      [PMID:28501145] [10.1016/j.talanta.2017.03.099]
15. Lan-Zhi Wang, Xiao-Qing Li, Ying-Shuang An.  (2015)  1,5-Benzodiazepine derivatives as potential antimicrobial agents: design, synthesis, biological evaluation, and structure–activity relationships.  ORGANIC & BIOMOLECULAR CHEMISTRY,  13  (19): (5497-5509).  [PMID:25875695] [10.1039/C5OB00655D]
16. Junjie Li, Chunhua Lai, Xiongzhi Xiang, Lei Wang.  (2015)  Synthesis and characterization of poly-Schiff bases with a donor–acceptor structure containing thiophene units as thermoelectric materials.  Journal of Materials Chemistry C,  (11): (2693-2701).  [PMID:] [10.1039/C5TC00065C]
17. Zhenyu Jiang, Zhaobei Chen, Zhonglin Luo, Biaobing Wang.  (2024)  A P/N/S containing flame retardant for epoxy resins with excellent optical, mechanical and flame retardant properties.  POLYMER DEGRADATION AND STABILITY,      [PMID:] [10.1016/j.polymdegradstab.2024.110783]
18. Liping Wei, Kexin Zhou, Hui-qiang Li, Ping Yang, Baicang Liu.  (2024)  Cobalt based bimetallic catalysts for heterogeneous electro-Fenton adapting to vary pH for HEDP and MIT degradation.  ENVIRONMENTAL TECHNOLOGY,      [PMID:38780498] [10.1080/09593330.2024.2356226]
19. Shoulian Wei, Shenwei Huang, Jun Zhou, Chun Xiao, Jiangfei Cao, Jibo Xiao, Chunsheng Xie.  (2025)  Magnetic Carbon Porous Polymer Prepared from a New Suspended Emulsion for the Absorption of Heavy Metal Ions.  Polymers,  17  (3): (257).  [PMID:39940461] [10.3390/polym17030257]
20. Yunjie Cao, Xijie Feng, Wenbo Sui, Yufei Shi, Zihan Xie, Xinyan Xian, Jun Wu, Jun Zhou, Jie Dong, Changyu Shen.  (2024)  Polyacrylamide/2-Thiophenecarboxaldehyde Hydrogel Functionalized Fiber Optic Mercury Ion Trace Detection.  IEEE SENSORS JOURNAL,      [PMID:] [10.1109/JSEN.2024.3461790]
21. Pan Wang, Jingjing Liu, Xinrui Hou, Zhixuan Chen.  (2024)  Preparation and luminescence properties of polypyrrole-thiophene derivatives.  INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION,      [PMID:] [10.1080/1023666X.2024.2357397]
22. Brian Musikavanhu, Xin Huang, Quanhong Ma, Zhaoli Xue, Lei Feng, Long Zhao.  (2024)  Rhodamine-benzothiazole-thiophene: A triangular molecular tool for simultaneous detection of Hg2+ and Cu2+.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.111549]
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