3-Indolepropionic acid（IPA） - Moligand™, ≥98% , Inhibitor of Proton-coupled Amino acid Transporter 1, CAS No.830-96-6, Inhibitor of Proton-coupled Amino acid Transporter 1

CAS: 830-96-6 Cat. No.: I103959 Molecular Weight: 189.21 Beilstein Registry Number: 147733 EC Number: 212-600-1

GRADE & PURITY Moligand™, ≥98%

Synonyms

IPA | 3-(Indol-3-yl)propanoic acid | BDBM31879 | Indole-3-propionic acid | 3-Indole propionic acid | 3-Indolepropionic acid | b-Indole-3-propionate | b-Indolepropionic acid | HY-W015229 | InChI=1/C11H11NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H

Storage

Protected from light,Room temperature,Desiccated,Cool

Shipped In

Normal

Overview

3-Indolepropionic acid is an effective inhibitor of aggregation of misfolded β-amyloid protein (Abeta). Three-component one-pot procedure has been reported to assemble 3-indolepropionic acids.

Function
3-Indolepropionic acid (Indolepropionic acid) is shown to be a powerful antioxidant with potential in the treatment for Alzheimer’s disease.

Specifications

Synonyms

IPA | 3-(Indol-3-yl)propanoic acid | BDBM31879 | Indole-3-propionic acid | 3-Indole propionic acid | 3-Indolepropionic acid | b-Indole-3-propionate | b-Indolepropionic acid | HY-W015229 | InChI=1/C11H11NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4, 7, 12H

Specifications & Purity

Moligand™, ≥98%

Storage

Protected from light, Room temperature, Desiccated, Cool

Shipped In

Normal

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of Proton-coupled Amino acid Transporter 1

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 488179788
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488179788
• Canonical Smiles: C1=CC=C2C(=C1)C(=CN2)CCC(=O)O
• IUPAC Name: 3-(1H-indol-3-yl)propanoic acid
• InChIKey: GOLXRNDWAUTYKT-UHFFFAOYSA-N
• INCHI: 1S/C11H11NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6H2,(H,13,14)
• Isomeric SMILES: C1=CC=C2C(=C1)C(=CN2)CCC(=O)O
• WGK Germany: 3
• RTECS: NM1329000
• Molecular Weight: 189.21
• Beilstein: 147733
• Reaxy-Rn: 147733
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=147733&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Indoles and derivatives
      • Subclass Indolyl carboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Indoles and derivatives
• Subclass: Indolyl carboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Indolyl carboxylic acids and derivatives
• Alternative Parents: 3-alkylindoles Substituted pyrroles Benzenoids Heteroaromatic compounds Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Indolyl carboxylic acid derivative - 3-alkylindole - Indole - Substituted pyrrole - Benzenoid - Heteroaromatic compound - Pyrrole - Azacycle - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Carbonyl group - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as indolyl carboxylic acids and derivatives. These are compounds containing a carboxylic acid chain (of at least 2 carbon atoms) linked to an indole ring.
• External Descriptors: indol-3-yl carboxylic acid

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

SLC36A1 Tchem Proton-coupled amino acid transporter 1 (1 Activities)

Discover Target: SLC36A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KYAT1 Tbio Kynurenine--oxoglutarate transaminase I (96 Activities)

Discover Target: KYAT1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mycobacterium tuberculosis (203094 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mixed cortical cells (27 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rotifers (49 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: it is slightly soluble in water.
• Sensitivity: Light sensitive.
• Melt Point(°C): 130-136°C
• Molecular Weight: 189.210 g/mol
• XLogP3: 1.800
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 189.079 Da
• Monoisotopic Mass: 189.079 Da
• Topological Polar Surface Area: 53.100 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 217.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

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22. Yunlei Zhou, Huanshun Yin, Jie Li, Bingchen Li, Xue Li, Shiyun Ai, Xiansheng Zhang.  (2015)  Electrochemical biosensor for microRNA detection based on poly(U) polymerase mediated isothermal signal amplification.  BIOSENSORS & BIOELECTRONICS,      [PMID:26700579] [10.1016/j.bios.2015.12.009]

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