Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 37 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor ( SSRI ) class used for antidepressant research.
| Isomeric SMILES | CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F |
|---|---|
| Alternate CAS | 56296-78-7 |
| UN Number | 3265 |
| Packing Group | I |
| Molecular Weight | 309.33 |
| Reaxy-Rn | 3991406 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3991406&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
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View spec sheet →| 1. Yanqing Ma, Shuanghe Wang, Shanshan Luo, Yixi Zeng, Guofeng Shi, Lanyue zhang, Hui Li. (2025) Antidepressant-like Effects of Five Essential Oils Inhaled in Reserpine-induced Depressed Mouse Models. CHEMISTRY & BIODIVERSITY, [PMID:40644689] [10.1002/cbdv.202500971] |
| 2. Ya-Nan Tang, Yun-Feng Bai, Ai Dong, Qin-Ling Rao, Hong-Hua Wu, Chun-Guo Wang, Yan-Tong Xu. (2025) Antidepressant effects of total phenols and total saponins of Kai-Xin-San mediated by synaptic plasticity induced by BDNF/TrkB/Akt pathway. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:40816580] [10.1016/j.jep.2025.120423] |
| 3. Jiahui Wu, Xin Li, Xiaoning Huang, Yun Zhu, Hongquan Yu, Yingjie Xia, Suisui Guo, Xiaoyang Wang, Tingxia Dong, Karl Wah Keung Tsim, Yue Zhu. (2025) Kai-Xin-San, an ancient herbal mixture for anti-depression, mitigates the fluoxetine-induced gut dysbiosis and intestinal damage in chronic unpredictable mild stressed mice. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:40882788] [10.1016/j.jep.2025.120484] |
| 4. Jingxin Chen, Jian Shi, Wenting Gu, Weiye Li, Ruiyin Lyu, Xueping Wu, Junming Wang, Chunhong Liu. (2025) Multi-Target Antidepressant Action of Citrus medica L. var. sarcodactylis Swingle (Bergamot) Essential Oil: From PI3K/AKT-Driven Apoptosis Inhibition to BDNF/5-HT Signaling Activation. SOUTH AFRICAN JOURNAL OF BOTANY, [PMID:] [10.1016/j.sajb.2025.07.033] |
| 5. Yiyang Du, Tingxu Yan, Bo Wu, Bosai He, Ying Jia. (2023) Research on the mechanism of antidepressive effect of Suanzaoren Decoction through TLR4/MyD88/NF-κB pathway and Wnt/β-catenin pathway. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:37739105] [10.1016/j.jep.2023.117190] |
| 6. Jiao-Zhao Yan, Guang-Xiang Li, Si-Rui Sun, Lin-Yu Cui, Yong-Yu Yin, Yun-Feng Li. (2023) A rate-limiting step in antidepressants onset: Excitation of glutamatergic pyramidal neurons in medial prefrontal cortex of rodents. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, [PMID:38065287] [10.1016/j.pnpbp.2023.110911] |
| 7. Yu Hui, Shao Shumin, Xu Junnan, Guo Haibiao, Zhong Zhangfeng, Xu Jiangping. (2022) Persimmon leaf extract alleviates chronic social defeat stress-induced depressive-like behaviors by preventing dendritic spine loss via inhibition of serotonin reuptake in mice. Chinese Medicine, 17 (1): (1-20). [PMID:35668445] [10.1186/s13020-022-00609-4] |
| 8. Qianqian Shang, Huajing Liu, Hang Mei, Chuixiu Huang, Xiantao Shen. (2022) Multi-extraction system with identical supported semi-liquid membrane: Enhanced stability for coextraction of acidic and basic drugs. TALANTA, [PMID:35462249] [10.1016/j.talanta.2022.123485] |
| 9. Tiantian Wang, Ruihe Zheng, Song Sun. (2022) Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascade. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, [PMID:35158201] [10.1016/j.bbrc.2022.02.015] |
| 10. Ruiqin Zhu, Hang Mei, Huajing Liu, Changbao Hong, Xiantao Shen, Chuixiu Huang. (2021) Successive liquid-phase microextraction of acidic and basic analytes. ANALYTICA CHIMICA ACTA, [PMID:35057942] [10.1016/j.aca.2021.339335] |
| 11. Yanqiu Chen, Mei Wan, Yi Zhong, Tingfang Gao, Yuehan Zhang, Fen Yan, Da Huang, Yuanzi Wu, Zuquan Weng. (2021) Partially Hydrolyzed Guar Gum Modulates Gut Microbiota, Regulates the Levels of Neurotransmitters, and Prevents CUMS-Induced Depressive-Like Behavior in Mice. MOLECULAR NUTRITION & FOOD RESEARCH, 65 (16): (2100146). [PMID:34125489] [10.1002/mnfr.202100146] |
| 12. Yun Wang, Ce Gao, Tianyu Gao, Lu Zhao, Shiguang Zhu, Lin Guo. (2021) Plasma exosomes from depression ameliorate inflammation-induced depressive-like behaviors via sigma-1 receptor delivery. BRAIN BEHAVIOR AND IMMUNITY, [PMID:33607235] [10.1016/j.bbi.2021.02.004] |
| 13. Li Fan, Ying Peng, Jingwen Wang, Ping Ma, Lijuan Zhao, Xiaobo Li. (2021) Total glycosides from stems of Cistanche tubulosa alleviate depression-like behaviors: bidirectional interaction of the phytochemicals and gut microbiota. PHYTOMEDICINE, [PMID:33636477] [10.1016/j.phymed.2021.153471] |
| 14. Xin Shan, Jing Chen, Shilin Dai, Jie Wang, Zhiheng Huang, Zhiyang Lv, Qian Wang, Qinan Wu. (2020) Cyanidin-related antidepressant-like efficacy requires PI3K/AKT/FoxG1/FGF-2 pathway modulated enhancement of neuronal differentiation and dendritic maturation. PHYTOMEDICINE, [PMID:32593103] [10.1016/j.phymed.2020.153269] |
| 15. Lan Zhang, Yue Yang, Lei Di, Jun-long Li, Ning Li. (2020) Erxian decoction, a famous Chinese medicine formula, antagonizes corticosterone-induced injury in PC12 cells, and improves depression-like behaviours in mice. PHARMACEUTICAL BIOLOGY, [PMID:32476554] [10.1080/13880209.2020.1765812] |
| 16. Yiqun Chen, Yang Tong, Yingwen Xue, Zizheng Liu, Min Tang, Li-Zhi Huang, Senlin Shao, Zheng Fang. (2019) Degradation of the β-blocker propranolol by sulfite activation using FeS. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2019.123884] |
| 17. Hui Wang, Ling Xiao, Huiling Wang, Gaohua Wang. (2019) Involvement of chronic unpredictable mild stress-induced hippocampal LRP1 up-regulation in microtubule instability and depressive-like behavior in a depressive-like adult male rat model. PHYSIOLOGY & BEHAVIOR, [PMID:31770536] [10.1016/j.physbeh.2019.112749] |
| 18. Li Yang, Peng Ying, Ma Ping, Yang Hanlin, Xiong Haiyan, Wang Mengyue, Peng Chongsheng, Tu Pengfei, Li Xiaobo. (2018) Antidepressant-Like Effects of Cistanche tubulosa Extract on Chronic Unpredictable Stress Rats Through Restoration of Gut Microbiota Homeostasis. Frontiers in Pharmacology, [PMID:30186183] [10.3389/fphar.2018.00967] |
| 19. Hongxia Zhao, Lingge Huang, Jian Liu, Min Feng, Yeqian Liu, Hong Li, Shan Gong, Chunming Chen, Shuiqing Zeng, Weiqiong Ren. (2025) A vascular endothelial cell, neuron, and microglia tri-culture model to study hypertension-related depression. Frontiers in Cellular Neuroscience, [PMID:40230380] [10.3389/fncel.2025.1553309] |
| 20. Ning Jiang, Caihong Yao, Yiwen Zhang, Yuzhen Chen, Fang Chen, Yanqin Luo, Muhammad Iqbal Choudhary, Ruile Pan, Xinmin Liu. (2024) Antidepressant effects of Parishin C in chronic social defeat stress-induced depressive mice. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:38331122] [10.1016/j.jep.2024.117891] |
| 21. Ya Zhu, Lan Li, Shaokui Yi, Rui Hu, Jianjun Wu, Jinqian Xu, Junguang Xu, Qinnan Zhu, Shijia Cen, Yuxuan Yuan, Da Sun, Waqas Ahmad, Huilan Zhang, Xuan Cao, Jingjuan Ju. (2024) Deep learning-assisted detection of psychoactive water pollutants using behavioral profiling of zebrafish embryos. JOURNAL OF HAZARDOUS MATERIALS, [PMID:39486333] [10.1016/j.jhazmat.2024.136358] |
| 22. Fengjiao Liu, Yaxin Jia, Liwei Zhao, Li-na Xiao, Xizhen Cheng, Yingying Xiao, Ying Zhang, Yuling Zhang, Huimin Yu, Qiao-en Deng, Yuanyuan Zhang, Yimeng Feng, junfang Wang, Yonggang Gao, Xuan Zhang, Yunyun Geng. (2024) Escin ameliorates CUMS-induced depressive-like behavior via BDNF/TrkB/CREB and TLR4/MyD88/NF-κB signaling pathways in rats. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:39426465] [10.1016/j.ejphar.2024.177063] |
| 23. Wenyu Sun, Huiyun Qiu, Susu Lin, Shengqiang Tong. (2024) Impact of the degree of substitution on the enantioseparation of anionic β-cyclodextrin in liquid‒liquid extraction and countercurrent chromatography: Insights from molecular docking simulations. JOURNAL OF CHROMATOGRAPHY A, [PMID:39146865] [10.1016/j.chroma.2024.465255] |
| 24. Lu Yang, Zijin Lin, Ruijing Mu, Wenhan Wu, Hao Zhi, Xiaodong Liu, Hanyu Yang, Li Liu. (2024) Neurons enhance blood–brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion. eLife, [PMID:39475379] [10.7554/eLife.96161] |
| 25. Peng Wang, Hui Ouyang, Guofang Bi, Fengting Liang, Shuang Hu, Chenhua Wu, Xiaowen Jiang, Wenhong Zhou, Dan Li, Shuaishuai Zhang, Xiao Yang, Mingliang Zhao, Jian-Hong Fang, Haitao Wang, Wei Jia, Zheng-jiang Zhu, Huichang Bi. (2024) Schisandrol B alleviates depression-like behavior in mice by regulating bile acid homeostasis in the brain-liver-gut axis via the pregnane X receptor. PHYTOMEDICINE, [PMID:39809031] [10.1016/j.phymed.2024.156340] |
| 26. Shan Liu, Yue Zhang, Hao Zhou, Yating Ma, Fangzhou Huang, Tianyuan Lei, Qingbin Wang, Shangmin Yu. (2025) Ginsenoside Re Inhibits NLRP3 Inflammasome Activation in Depressive Mice by Promoting PINK1-Mediated Mitophagy. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:40298124] [10.1021/acs.jafc.4c09773] |
| 27. Xinxin Zheng, Sidi Cun, Jiatai Yin, Xue Zhao, Yunshan Wang, Jing Wang, Qian Li, Xinfeng Zhao. (2025) Immobilizing the Endogenous 5-Hydroxytryptamine Transporter by Ligand-Directed and Proximity-Catalyzed Acyl Imidazole Chemistry for Affinity Chromatographic Analysis. ANALYTICAL CHEMISTRY, [PMID:40317770] [10.1021/acs.analchem.5c01334] |
| 28. Xue Zhao, Yunshan Wang, Jiatai Yin, Sidi Cun, Yuanyuan Ou, Qian Li, Xinfeng Zhao, Yajun Zhang. (2025) Integrating click chemistry into protein expression for efficient preparation of immobilized protein bio-surface with enhanced stability and reproducibility in affinity chromatography. ANALYTICA CHIMICA ACTA, [PMID:40409903] [10.1016/j.aca.2025.344142] |
| 29. Yu Cao, Kexuan Zhao, Yudi Zhao, Ying Ni, Zicheng Zhang, Xinyi Yuan, Jiamei Ning, Qinghua Song, Fan Zhao, Ling He, Tong Chen. (2025) Arbutin ameliorated depression by inhibiting neuroinflammation and modulating intestinal flora. PHYTOMEDICINE, [PMID:40554291] [10.1016/j.phymed.2025.156944] |
| 30. Shirong Li, Junwen Ding, Zihan Liu, Jinjin Jia, Qian Zhao, Peijie Li, Han Zhang, Guibai Li, Langming Bai, Heng Liang. (2025) Interface-Facilitated Removal of Environmental Micropollutants by Nanofiltration Membranes Prepared from Amino Acid-Mediated Interfacial Polymerization: Mechanistic Insights into Micropollutant Interfacial Partitioning Regulation. ENVIRONMENTAL SCIENCE & TECHNOLOGY, [PMID:40493848] [10.1021/acs.est.5c04586] |
| 31. Zhao Xue, Yu Yi, Yang Lili, Liu Hui, Lei Ting. (2025) Screening of selective serotonin reuptake inhibitors from Cyperus rotundus using immobilized neurotransmitter transporter affinity chromatography for antidepressant discovery. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, [PMID:41062859] [10.1007/s00216-025-06105-6] |
| 32. Zi Wang, Peng Liu, Zixin Wang, Hongzhi Liu, Gaoxin Dai, Shirong Li, Qian Zhao, Heng Liang, Langming Bai. (2025) Tailoring Polyamide Nanofiltration Membranes for the Removal of Environmental Micropollutants: Synergistic Diffusion-Reaction Modulation in Interfacial Polymerization. ENVIRONMENTAL SCIENCE & TECHNOLOGY, [PMID:41330725] [10.1021/acs.est.5c10956] |
| 33. Wenjia Yang, Lu Zeng, Xinyu Zhang, Xiangrui Li, Qiujin Zhu. (2026) A time-resolved fluorescent signal tag-mediated immunochromatographic assay for the rapid and sensitive detection of fluoxetine. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, [PMID:] [10.1016/j.jfca.2026.108884] |
| 34. Yingqian Zhang, Qi Lai, Tangcong Chen, Yueyang Luo, Mengdie Li, Mengqi Niu, Jing Li, Michael Maes. (2026) Hypersensitization of peripheral immune cells from major depressive disorder patients is mildly attenuated by fluoxetine in vitro. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, [PMID:41529783] [10.1016/j.pnpbp.2026.111608] |
| 35. Jinni Meng, Ping Wei, Heping Yang, Lin Chen, Cheng Peng, Ou Dai, Qinmei Zhou, Liang Xiong. (2026) Levistilide A from Ligusticum chuanxiong alleviates LPS-induced depression- and anxiety-like behaviors by promoting mitophagy through the SIRT3/PINK1/Parkin pathway. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:41554453] [10.1016/j.jep.2025.121146] |
| 36. Zhao Chen-di, Liu Nan-feng, Samad Abdus, Tian Zhen, Xu Hong-mei, Tian Jiao. (2026) Neferine alleviated corticosterone-induced depressive-like behaviors in mice via the inhibition of TNF/NF-κB pathway by binding to PPARγ. MOLECULAR NEUROBIOLOGY, 63 (1): (374). [PMID:41553445] [10.1007/s12035-025-05659-x] |
| 37. Ya Zou, Zhouhong Tan, Jiaqian Li, Anzhong Peng, Jieli He. (2026) Rapid and sensitive fluorescence detection of clozapine via g-C3N4 nanosheet-based quenching. Analytical Methods, [PMID:] [10.1039/D5AY02159F] |
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