Articles by Topic "molecular building blocks"

1. OSF/ASF Dual-Channel Toolbox: Divergent Reactions of Four-Membered Ring Sulfonyl Fluorides, Condition “Knobs,” and Selection Navigation
   posted this at Jan 19, 2026

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   A recurring tension in medicinal design is this: you want stronger binding, better solubility/exposure, more controllable metabolism and selectivity—without tearing down and rebuilding the entire scaffold. Over the past decade-plus, “small, polar, sp³-rich” four-membered rings—oxetanes ...