The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
· · COA & SDS available for every product · Same-day shipping on in-stock items AG 1478 hydrochloride - ≥98% , CAS No.170449-18-0
Synonyms
AG 1478 HYDROCHLORIDE | AG-1478.hcl | 4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-, monohydrochloride | DS-13538 | MLS000758209 | AG 1478 HCl | AG1478 HCl | AG-1478 HCl | BCPP000425 | Tyrphostin AG-1478 hydrochloride;AG 1478 hydrochloride;NSC 6932
Storage
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
🧪
Why this grade ≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
🌡
Storage & shipping Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
📋
Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
📚
Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
AG 1478 HYDROCHLORIDE | AG-1478.hcl | 4-Quinazolinamine, N-(3-chlorophenyl)-6, 7-dimethoxy-, monohydrochloride | DS-13538 | MLS000758209 | AG 1478 HCl | AG1478 HCl | AG-1478 HCl | BCPP000425 | Tyrphostin AG-1478 hydrochloride;AG 1478 hydrochloride;NSC 6932
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
Potent and selective inhibitor of epidermal growth factor receptor kinase (IC50values 3 nM for EGFR and > 100μM for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cellsin vitro(IC50= 1μM).
Storage
Store at -20°C, Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers Canonical Smiles COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC.Cl IUPAC Name N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine;hydrochloride InChIKey WDJDYIUSDDVWKB-UHFFFAOYSA-N INCHI 1S/C16H14ClN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H Isomeric SMILES COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC.Cl Molecular Weight 352.22 Reaxy-Rn 7452865 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7452865&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Diazanaphthalenes Subclass Benzodiazines Intermediate Tree Nodes Quinazolines Direct Parent Quinazolinamines Alternative Parents Anisoles Aniline and substituted anilines Chlorobenzenes Aminopyrimidines and derivatives Alkyl aryl ethers Imidolactams Aryl chlorides Heteroaromatic compounds Azacyclic compounds Organochlorides Hydrochlorides Hydrocarbon derivatives Amines Molecular Framework Aromatic heteropolycyclic compounds Substituents Quinazolinamine - Anisole - Aniline or substituted anilines - Phenol ether - Alkyl aryl ether - Aminopyrimidine - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Pyrimidine - Imidolactam - Benzenoid - Heteroaromatic compound - Azacycle - Ether - Organochloride - Organohalogen compound - Organic oxygen compound - Amine - Organonitrogen compound - Organooxygen compound - Hydrochloride - Hydrocarbon derivative - Organic nitrogen compound - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as quinazolinamines. These are heterocyclic aromatic compounds containing a quianazoline moiety substituted by one or more amine groups. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 3.52, Max Conc. mM: 10 with gentle warming Molecular Weight 352.200 g/mol XLogP3 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 5 Rotatable Bond Count 4 Exact Mass 351.054 Da Monoisotopic Mass 351.054 Da Topological Polar Surface Area 56.300 Ų Heavy Atom Count 23 Formal Charge 0 Complexity 360.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 2
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator Reviews
We use cookies to ensure the website functions properly and, where permitted, to improve your experience. You can manage your preferences at any time in Settings. Learn more in our
Cookie Policy. Settings Agree All Decline
Shall we send you a message when we have discounts available?
Remind me later Allow
Thank you! Please check your email inbox to confirm.
Oops! Notifications are disabled.
Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
Copyright © 2023–present Aladdin Scientific Corp. All rights reserved.
C2321116