D-Arginine - Moligand™, ≥98% , CAS No.157-06-2

CAS: 157-06-2 Cat. No.: A109212 Molecular Weight: 174.2 Beilstein Registry Number: 1725412 EC Number: 205-866-5
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GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
HY-W016781 | UNII-R54Z304Z7C | (2R)-2-amino-5-[(diaminomethylidene)amino]pentanoic acid | A1029 | DS-2689 | EINECS 205-866-5 | Gamophen | J-300021 | (R,S)-2-Amino-5-guanidino-pentanoic acid | (2R)-2-amino-5-carbamimidamidopentanoic acid | M02984 | InChI=1
Storage
Protected from light,Room temperature
Shipped In
Normal
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Status
Price
Qty
1g
A109212-1g
10
$9.90
5g
A109212-5g
8

$14.90

$19.90
Save $5.00 (25.13%)
25g
A109212-25g
8

$35.90

$39.90
Save $4.00 (10.03%)
100g
A109212-100g
3
$108.90
500g
A109212-500g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$342.90
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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Protected from light,Room temperature Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 16 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

D-arginine (H-D-Arg-OH) is the D-isomer of arginine. Arginine is an α-amino acid that is used in the biosynthesis of proteins. D-Arginine is an inactive form of L-arginine. D-arginine can be used in myeloma and neurological disease research。

Specifications

Synonyms
HY-W016781 | UNII-R54Z304Z7C | (2R)-2-amino-5-[(diaminomethylidene)amino]pentanoic acid | A1029 | DS-2689 | EINECS 205-866-5 | Gamophen | J-300021 | (R, S)-2-Amino-5-guanidino-pentanoic acid | (2R)-2-amino-5-carbamimidamidopentanoic acid | M02984 | InChI=1
Specifications & Purity
Moligand™, ≥98%
Storage
Protected from light, Room temperature
Shipped In
Normal
Grade
Moligand™
Purity
≥98%
Names and Identifiers
Pubchem Sid488184640
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488184640
Canonical SmilesC(CC(C(=O)O)N)CN=C(N)N
IUPAC Name(2R)-2-amino-5-(diaminomethylideneamino)pentanoic acid
InChIKeyODKSFYDXXFIFQN-SCSAIBSYSA-N
INCHI1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m1/s1
Isomeric SMILES C(C[C@H](C(=O)O)N)CN=C(N)N
WGK Germany 3
Molecular Weight 174.2
Beilstein 1725412
Reaxy-Rn 2090768
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2090768&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
SubclassAmino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
Direct ParentD-alpha-amino acids
Alternative Parents Fatty acids and conjugates  Guanidines  Amino acids  Propargyl-type 1,3-dipolar organic compounds  Monocarboxylic acids and derivatives  Carboxylic acids  Carboximidamides  Organopnictogen compounds  Organic oxides  Monoalkylamines  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAliphatic acyclic compounds
Substituents D-alpha-amino acid - Fatty acid - Guanidine - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Carboximidamide - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Amine - Hydrocarbon derivative - Organic oxide - Primary amine - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Primary aliphatic amine - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as d-alpha-amino acids. These are alpha amino acids which have the D-configuration of the alpha-carbon atom.
External Descriptors Other amino acids
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
GH3 (79 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

25 results found

Lot NumberCertificate TypeDateItem
B2606065Certificate of AnalysisJan 20, 2026 A109212
B2606066Certificate of AnalysisJan 20, 2026 A109212
B2606067Certificate of AnalysisJan 20, 2026 A109212
L2505003Certificate of AnalysisApr 26, 2025 A109212
E2508183Certificate of AnalysisApr 26, 2025 A109212
E2508182Certificate of AnalysisApr 26, 2025 A109212
E2508114Certificate of AnalysisApr 26, 2025 A109212
E2508113Certificate of AnalysisApr 26, 2025 A109212
D2114171Certificate of AnalysisJan 08, 2025 A109212
D2418176Certificate of AnalysisMar 25, 2024 A109212
D2418177Certificate of AnalysisMar 25, 2024 A109212
D2418175Certificate of AnalysisMar 25, 2024 A109212
D2418174Certificate of AnalysisMar 25, 2024 A109212
E2311087Certificate of AnalysisJul 21, 2022 A109212
C2428044Certificate of AnalysisJul 21, 2022 A109212
B2505108Certificate of AnalysisJul 21, 2022 A109212
J2228188Certificate of AnalysisJul 21, 2022 A109212
J2228193Certificate of AnalysisJul 21, 2022 A109212
J2228211Certificate of AnalysisJul 21, 2022 A109212
B2207146Certificate of AnalysisDec 23, 2021 A109212
E2311077Certificate of AnalysisDec 23, 2021 A109212
E2311096Certificate of AnalysisDec 23, 2021 A109212
B2207149Certificate of AnalysisDec 23, 2021 A109212
B2207148Certificate of AnalysisDec 23, 2021 A109212
B2207147Certificate of AnalysisDec 23, 2021 A109212

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Chemical and Physical Properties
SensitivityAir Sensitive;Moisture sensitive; Light sensitive
Specific Rotation[α]-26° (C=8,6mol/L HCl)
Melt Point(°C)221-224°C
Molecular Weight174.200 g/mol
XLogP3-4.200
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass174.112 Da
Monoisotopic Mass174.112 Da
Topological Polar Surface Area128.000 Ų
Heavy Atom Count12
Formal Charge0
Complexity176.000
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Jingzhi Yang, Yami Ran, Shaopeng Liu, Chenhao Ren, Yuntian Lou, Pengfei Ju, Guoliang Li, Xiaogang Li, Dawei Zhang.  (2023)  Synergistic D-Amino Acids Based Antimicrobial Cocktails Formulated via High-Throughput Screening and Machine Learning.  Advanced Science,  11  (9): (2307173).  [PMID:38126652] [10.1002/advs.202307173]
2. Wei Jia, Xin Wang.  (2023)  3-Chloropropane-1,2-diol exposure adversely influenced the bio-accessibility signatures of digested infant foods by suppressing the destabilization of α-lactalbumin and d-aspartate oxidase in a dose-dependent manner.  FOOD CHEMISTRY,      [PMID:37385056] [10.1016/j.foodchem.2023.136729]
3. Arabi Maryam, Ostovan Abbas, Wang Yunqing, Mei Rongchao, Fu Longwen, Li Jinhua, Wang Xiaoyan, Chen Lingxin.  (2022)  Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination.  Nature Communications,  13  (1): (1-14).  [PMID:36180485] [10.1038/s41467-022-33448-w]
4. Xiao He, Yannv Qu, Xiaohong Lin, Jiapan Sun, Zhiru Jiang, Chaodong Wang, Yuanfei Deng, Fei Yan, Yansun Sun.  (2022)  Self-assembled D-arginine derivatives based on click chemical reactions for intracellular codelivery of antigens and adjuvants for potential immunotherapy.  Journal of Materials Chemistry B,  10  (18): (3491-3500).  [PMID:35403659] [10.1039/D2TB00346E]
5. Shutong Yang, Liancheng Gu, Fangling Wu, Xinhua Dai, Fuxing Xu, Qiaoyu Li, Xiang Fang, Shaoning Yu, Chuan-Fan Ding.  (2022)  The chirality determination of amino acids by forming complexes with cyclodextrins and metal ions using ion mobility spectrometry, and a DFT calculation.  TALANTA,      [PMID:35272154] [10.1016/j.talanta.2022.123363]
6. Xin-hui Zhou, Qing Liu, Hai-shui Wang.  (2021)  Chiral resolution of DL-glutamic acid by a chiral additive.  JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY,  97  (5): (1240-1246).  [PMID:] [10.1002/jctb.7018]
7. Lamei Yang, Feng Luo, Weili Wei.  (2021)  Simultaneous determination of the concentration and enantiomeric excess of amino acids with a coumarin-derived achiral probe.  Analytical Methods,  13  (16): (1905-1910).  [PMID:33913945] [10.1039/D1AY00271F]
8. Chengyi Xie, Liancheng Gu, Qidi Wu, Lei Li, Chenlu Wang, Jiancheng Yu, Keqi Tang.  (2020)  Effective Chiral Discrimination of Amino Acids through Oligosaccharide Incorporation by Trapped Ion Mobility Spectrometry.  ANALYTICAL CHEMISTRY,      [PMID:33226780] [10.1021/acs.analchem.0c03461]
9. Xia Lin, Shu Zhu, Qiao Xia, Jiao Ma, Yingzi Fu.  (2017)  An ultrasensitive electrochemiluminescent D-alanine biosensor based on the synergetic catalysis of a hemin-functionalized composite and gold–platinum nanowires.  Analytical Methods,  10  (1): (84-90).  [PMID:] [10.1039/C7AY02483E]
10. Wenrong Cai, Yanjing Shi, Ning Liu, Zheng-Zhi Yin, Junyao Li, Laidi Xu, Datong Wu, Yong Kong.  (2024)  A photothermal effect-based chiral sensor for chiral discrimination and sensitive detection.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:38788508] [10.1016/j.saa.2024.124494]
11. Songlin Chen, Zhihao Shen, Shuming Wen, Guang Han, Qicheng Feng.  (2024)  Effect of D-arginine as a novel depressant on the flotation separation of chalcopyrite from pyrite at low alkalinity.  APPLIED SURFACE SCIENCE,      [PMID:] [10.1016/j.apsusc.2024.161657]
12. Luzheng Dong, Jun Wu, Xiashi Zhu.  (2024)  Preparation of amino acid chiral ionic liquid and visual chiral recognition of glutamine and phenylalanine enantiomers.  CHIRALITY,  36  (4): (e23665).  [PMID:38570326] [10.1002/chir.23665]
13. Fengyuan Liu, Jiashan Xia, Chun Tao, Changmei Chen, Xiangshu Cheng, Rongchun Yi, Lulu Wang, Yue Wang, Tao Deng.  (2024)  The heterogeneity of physiological activity for chiral carbon dots derived from L/D/DL-arginine.  Journal of Materials Chemistry B,      [PMID:39283590] [10.1039/D4TB01294A]
14. Qiaoru Zhang, Yu Wang, Tianyu Song, Mashooq Khan, Yanjun Gong, Yongxian Guo, Qiongzheng Hu.  (2025)  Molecular Structural Transformation from the D–A to D–D’ of an AIEgen for the Highly Sensitive Detection of Hydrogen Peroxide in Exhaled Breath Condensate.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2025.137124]
15. Panyong Wang, Mingna Hu, Huimin Miao, Minghui Zan, Qiannan You, Li Li.  (2026)  Sustainable gelatin–carbon dot hydrogel coatings for fruit preservation: integrating antioxidant and antibacterial activities.  FOOD CHEMISTRY,      [PMID:41633169] [10.1016/j.foodchem.2026.148245]
16. Simin Zhang, Xiangfeng Chen, Yaping Shi, Xiangyu Zhu, Zongwei Cai.  (2026)  Soft-Chain-Induced Ultrahigh-Resolution Chiral Separation of Amino Acids via Bimetallic Immobilization in MALDI-TIMS-MS.  ANALYTICAL CHEMISTRY,      [PMID:41701523] [10.1021/acs.analchem.5c07869]
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