Favipiravir (T-705) - Moligand™, 10mM in DMSO , RNA-directed RNA polymerase inhibitor, CAS No.259793-96-9, RNA-directed RNA polymerase inhibitor

CAS: 259793-96-9 Cat. No.: F409106 Molecular Weight: 157.1 EC Number: 856-840-0

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

6-fluoro-3-hydroxypyrazine-2-carboxamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Favipiravir (T-705) is a potent and selectiveRNA-dependent RNA polymeraseinhibitor, used to treat influenza virus infections.
In vitro

Favipiravir shows anti-influenza virus activities with IC50 ranged from 0.013 to 0.48 μg/ml for the influenza A viruses, from 0.039 to 0.089 μg/ml for the influenza B viruses, and from 0.030 to 0.057 μg/ml for the influenza C viruses. In mammalian cell lines (MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells), Favipiravir shows no cytotoxicity at concentrations up to 1,000 μg/ml. In MDCK cells inoculated with seasonal influenza A (H1N1) viruses, Favipiravir induces lethal mutagenesis.

In vivo

In influenza virus-infected mice, Favipiravir (200 mg/kg/day, p.o.) protects the mice from death from influenza virus infection. In mice experimentally infected with Ebola virus, Favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively.
Cell Data

cell lines：

Concentrations：1000 μg/mL

Incubation Time：3 days

Powder Purity:≥99%

Specifications

Synonyms

6-fluoro-3-hydroxypyrazine-2-carboxamide

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

RNA-directed RNA polymerase inhibitor

Product Properties

• ALogP: -0.6

Names and Identifiers

• Isomeric SMILES: C1=C(N=C(C(=O)N1)C(=O)N)F
• Molecular Weight: 157.1
• Reaxy-Rn: 24892290
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24892290&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro
• Melt Point(°C): 192 °C

References

1. Dai Tianming, Wang Min, Wang Pengzhen, Dai Libing, Dai Renke, Meng Qingqi.  (2021)  Inhibition effects of eight anti-coronavirus drugs on glycosides metabolism and glycosidases in human gut microflora.  PHARMAZIE,  76  (5): (195-201).  [PMID:33964992] [10.1691/ph.2021.01005]

2. Shi-Ting Huang, Yong-Qian Lei, Peng-Ran Guo, Hong-Xin Chen, Shu-Chai Gan, Zeng-Hui Diao.  (2024)  Electrocatalytic degradation of Favipiravir by heteroatom (P and S) doped biomass-derived carbon with high oxygen reduction reaction activity.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.149543]

3. Yifeng Xu, Yaxuan Liu, Chuanzhou Liang, Wenshan Guo, Huu Hao Ngo, Lai Peng.  (2024)  Favipiravir biotransformation by a side-stream partial nitritation sludge: Transformation mechanisms, pathways and toxicity evaluation.  CHEMOSPHERE,      [PMID:38430943] [10.1016/j.chemosphere.2024.141580]

4. Bing Zhao, Chan-Ru Xiong, Yao Liu, Qing-Cai Yu, Xing Chen.  (2024)  Rapid detection of SARS-CoV-2 spike protein using a magnetic-assisted electrochemical biosensor based on functionalized CoFe2O4 magnetic nanomaterials.  TALANTA,      [PMID:38537348] [10.1016/j.talanta.2024.125986]