Foliglurax , Metabotropic glutamate receptor 4 positive allosteric modulator, CAS No.1883329-53-0, Metabotropic glutamate receptor 4 positive allosteric modulator

CAS: 1883329-53-0 Cat. No.: F671346 Molecular Weight: 421.5 PubChem CID: 135565465
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Synonyms
Foliglurax | FOLIGLURAX [WHO-DD] | DT-1687 | HY-108703 | DT1687 | BDBM50241580 | CHEMBL4089083 | FR50CP1D6W | DTXSID401337274 | (E)-6-(3-morpholinopropyl)-2-(thieno[3,2-c]pyridin-6-yl)-4H-chromen-4-one oxime | PXT-002331 | DB15292 | 4H-1-Benzopyran-4-one,
Storage
Room temperature
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Size
Status
Price
Qty
1mg
F671346-1mg
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$999.90
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Why this grade

for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
Foliglurax | FOLIGLURAX [WHO-DD] | DT-1687 | HY-108703 | DT1687 | BDBM50241580 | CHEMBL4089083 | FR50CP1D6W | DTXSID401337274 | (E)-6-(3-morpholinopropyl)-2-(thieno[3, 2-c]pyridin-6-yl)-4H-chromen-4-one oxime | PXT-002331 | DB15292 | 4H-1-Benzopyran-4-one,
Storage
Room temperature
Action Type
POSITIVE ALLOSTERIC MODULATOR
Mechanism of action
Metabotropic glutamate receptor 4 positive allosteric modulator
Product Properties
ALogP3.7
Names and Identifiers
Canonical SmilesC1COCCN1CCCC2=CC3=C(C=C2)OC(=CC3=NO)C4=NC=C5C=CSC5=C4
IUPAC Name(NE)-N-[6-(3-morpholin-4-ylpropyl)-2-thieno[3,2-c]pyridin-6-ylchromen-4-ylidene]hydroxylamine
InChIKeyZTEDNASHAWNBKQ-NCELDCMTSA-N
INCHI1S/C23H23N3O3S/c27-25-19-13-22(20-14-23-17(15-24-20)5-11-30-23)29-21-4-3-16(12-18(19)21)2-1-6-26-7-9-28-10-8-26/h3-5,11-15,27H,1-2,6-10H2/b25-19+
Isomeric SMILES C1COCCN1CCCC2=CC\3=C(C=C2)OC(=C/C3=N\O)C4=NC=C5C=CSC5=C4
PubChem CID 135565465
Molecular Weight 421.5

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassBenzopyrans
Subclass1-benzopyrans
Intermediate Tree Nodes Not available
Direct Parent1-benzopyrans
Alternative Parents Thienopyridines  Aralkylamines  Pyridines and derivatives  Morpholines  Benzenoids  Thiophenes  Heteroaromatic compounds  Trialkylamines  Oxacyclic compounds  Dialkyl ethers  Azacyclic compounds  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents 1-benzopyran - Thienopyridine - Aralkylamine - Benzenoid - Pyridine - Oxazinane - Morpholine - Heteroaromatic compound - Thiophene - Tertiary aliphatic amine - Tertiary amine - Oxacycle - Azacycle - Ether - Dialkyl ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Amine - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as 1-benzopyrans. These are organic aromatic compounds that 1-benzopyran, a bicyclic compound made up of a benzene ring fused to a pyran, so that the oxygen atom is at the 1-position.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
GRM4 Tchem Metabotropic glutamate receptor 4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRM4 Tchem Metabotropic glutamate receptor 4 (2320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Brain (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
Molecular Weight421.500 g/mol
XLogP33.700
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass421.146 Da
Monoisotopic Mass421.146 Da
Topological Polar Surface Area95.400 Ų
Heavy Atom Count30
Formal Charge0
Complexity652.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds1
Covalently-Bonded Unit Count1
Solution Calculators
Reviews

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