Phenformin hydrochloride - ≥97% , CAS No.834-28-6

CAS: 834-28-6 Cat. No.: P102146 Molecular Weight: 241.72 EC Number: 212-637-3

GRADE & PURITY ≥97%

Synonyms

1-Phenethylbiguanide hydrochloride | Phenethylbiguanide hydrochloride | Phenformin (hydrochloride) | Phenformin.HCl | Dipar | USAF VI-6 | Meltrol | 834-28-6 | Phenformin HCl | Meltrol-50 | 1-(Diaminomethylidene)-2-(2-phenylethyl)guanidine hydrochloride |

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate AMPK activity.

Specifications

Synonyms

1-Phenethylbiguanide hydrochloride | Phenethylbiguanide hydrochloride | Phenformin (hydrochloride) | Phenformin.HCl | Dipar | USAF VI-6 | Meltrol | 834-28-6 | Phenformin HCl | Meltrol-50 | 1-(Diaminomethylidene)-2-(2-phenylethyl)guanidine hydrochloride |

Specifications & Purity

≥97%

Biochemical and Physiological Mechanisms

Activates AMPK, increasing activity and phosphorylation. Antitumor effects. Active in vivo .

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥97%

Names and Identifiers

• Pubchem Sid: 488181825
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488181825
• Canonical Smiles: C1=CC=C(C=C1)CCN=C(N)N=C(N)N.Cl
• IUPAC Name: 1-(diaminomethylidene)-2-(2-phenylethyl)guanidine;hydrochloride
• InChIKey: YSUCWSWKRIOILX-UHFFFAOYSA-N
• INCHI: 1S/C10H15N5.ClH/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H6,11,12,13,14,15);1H
• Isomeric SMILES: C1=CC=C(C=C1)CCN=C(N)N=C(N)N.Cl
• WGK Germany: 3
• RTECS: DU2200000
• UN Number: 2811
• Packing Group: I
• Molecular Weight: 241.72
• Reaxy-Rn: 35474258
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=35474258&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Class Organonitrogen compounds
      • Subclass Guanidines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Class: Organonitrogen compounds
• Subclass: Guanidines
• Intermediate Tree Nodes: Not available
• Direct Parent: Biguanides
• Alternative Parents: Benzene and substituted derivatives Propargyl-type 1,3-dipolar organic compounds Carboximidamides Organopnictogen compounds Imines Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Biguanide - Benzenoid - Monocyclic benzene moiety - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Imine - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as biguanides. These are organic compounds containing two N-linked guanidines.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

Discover Target: TSHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPARA Tclin Peroxisome proliferator-activated receptor alpha (9197 Activities)

Discover Target: PPARA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)

Discover Target: THRB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CXCL8 Tchem Interleukin-8 (642 Activities)

Discover Target: CXCL8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Lymphoblastoid cell (5959 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)

Discover Target: HIF1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMN1 Tchem Survival motor neuron protein (34246 Activities)

Discover Target: SMN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

Discover Target: IDH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)

Discover Target: Nr1i2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Hygroscopic
• Molecular Weight: 241.720 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 241.109 Da
• Monoisotopic Mass: 241.109 Da
• Topological Polar Surface Area: 103.000 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 236.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Huanan Huang, Yihui Chen, Meilin Ni, Jing Du, Chunyan Hou, Xiaoqiang Qiao, Guozhou Cao, Tingting Wang.  (2023)  Sodium hexametaphosphate-treated halloysite based solid-phase extraction of biguanides from dietary supplements.  Analytical Methods,  15  (21): (2685-2692).  [PMID:37226487] [10.1039/D3AY00400G]

2. Yiling Ruan, Xinran Li, Linjun You, Jungen Chen, Yueyue Shen, Junying Zhang, Yaozuo Yuan, Lifeng Kang, Chao Qin, Chunyong Wu.  (2021)  Effect of Pharmaceutical Excipients on Intestinal Absorption of Metformin via Organic Cation-Selective Transporters.  MOLECULAR PHARMACEUTICS,      [PMID:33956455] [10.1021/acs.molpharmaceut.0c01104]

3. Pan Li, Huan He, Dongyue Lin, Liangbao Yang.  (2019)  Highly sensitive detection of an antidiabetic drug as illegal additives in health products using solvent microextraction combined with surface-enhanced Raman spectroscopy.  ANALYST,  144  (24): (7406-7411).  [PMID:31670319] [10.1039/C9AN01688K]

4. Dongmei Cui, Li Mi, Xuan Xu, Jusheng Lu, Jing Qian, Songqin Liu.  (2014)  Nanocomposites of Graphene and Cytochrome P450 2D6 Isozyme for Electrochemical-Driven Tramadol Metabolism.  LANGMUIR,      [PMID:25222611] [10.1021/la502699m]

5. Min Yu, Jian-Qin Yan, Ling-Yang Wang, Zhi-Yong Wu, Meng-Yao Wu, Yong Sun, Yan-Tuan Li.  (2024)  Integrating Theory with Experimental Studies on the Directed Assembly of Phenforminium 5-Fluorouracilate toward Enhanced In Vitro/Vivo Properties and Synergistic Antitumor Efficacy.  CRYSTAL GROWTH & DESIGN,      [PMID:] [10.1021/acs.cgd.4c00295]

6. Qin Zeng, Yiwen Chen, Weihuang Yang, Zheling Zhang, Wenfeng Liu, Yang Zhang, Yu Huang, Dongjie Wang, Qiaogan Liao, Jian Zhang.  (2025)  Fabrication of Printed Mesoscopic Perovskite Solar Cells Based on Nonannealing Strategy Perovskite Film to Achieve PCE > 18%.  ACS Applied Materials & Interfaces,      [PMID:40522134] [10.1021/acsami.5c04888]