Experimental design of human bioavailability of Irbesartan capsules
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Experimental design of human bioavailability of Irbesartan capsules
·Reviewed·Published ·Updated ·8 min read
Summary
Irbesartan is an AT1 receptor blocker and is used clinically in the treatment of hypertension. It is expected to be a first-line anti-hypertensive drug because of its precise efficacy and virtually no adverse effects at therapeutic doses (commonly used 50-300 mg/d, tolerated >900 mg/d). Pharmacokinetic studies have shown that Irbesartan capsules are orally absorbed relatively quickly (Tmax 1.5-2 h), with an absolute bioavailability of about 60%-80% and a half-life t1/2 of about 11-16 h. The drug has been shown to be effective in the treatment of hypertension.
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Da — when not otherwise indicated, molecular weight units are daltons. Mw — weight-average molecular weight. Mn — number-average molecular weight.
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Aladdin Scientific. "Experimental design of human bioavailability of Irbesartan capsules" Aladdin Knowledge Base, updated Dec 24, 2024. https://www.aladdinsci.com/us_en/faqs/experimental-design-of-human-bioavailabi-en.html
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