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· · COA & SDS available for every product · Same-day shipping on in-stock items MK-5108 (VX-689) - Moligand™, ≥98% , Serine/threonine-protein kinase Aurora-A inhibitor, CAS No.1010085-13-8, Serine/threonine-protein kinase Aurora-A inhibitor
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98% Synonyms
HMS3656D06 | NCGC00024591-03 | BRD-K53665955-001-01-4 | GTPL8061 | MK 5108 | NSC800796 | NSC-800796 | MFCD22124479 | trans-4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid | SW220174-1 | trans-4-(
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
HMS3656D06 | NCGC00024591-03 | BRD-K53665955-001-01-4 | GTPL8061 | MK 5108 | NSC800796 | NSC-800796 | MFCD22124479 | trans-4-(3-chloro-2-fluorophenoxy)-1-[[6-(1, 3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid | SW220174-1 | trans-4-(
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
MK-5108 (VX-689) is a highly selective Aurora-A kinase inhibitor with an IC50 of 0.064 nM. MK-5108 is a novel small molecule with potent inhibitory activity against Aurora-A kinase. Although most of the Aurora-kinase inhibitors target bot
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Serine/threonine-protein kinase Aurora-A inhibitor
Product Properties Names and Identifiers Pubchem Sid 488200675 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488200675 Canonical Smiles C1CC(CCC1OC2=C(C(=CC=C2)Cl)F)(CC3=NC(=CC=C3)NC4=NC=CS4)C(=O)O IUPAC Name 4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid InChIKey LCVIRAZGMYMNNT-UHFFFAOYSA-N INCHI 1S/C22H21ClFN3O3S/c23-16-4-2-5-17(19(16)24)30-15-7-9-22(10-8-15,20(28)29)13-14-3-1-6-18(26-14)27-21-25-11-12-31-21/h1-6,11-12,15H,7-10,13H2,(H,28,29)(H,25,26,27) Isomeric SMILES C1CC(CCC1OC2=C(C(=CC=C2)Cl)F)(CC3=NC(=CC=C3)NC4=NC=CS4)C(=O)O Molecular Weight 461.94 Reaxy-Rn 24898269 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24898269&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Benzenoids Class Phenol ethers Subclass Not available Intermediate Tree Nodes Not available Direct Parent Phenol ethers Alternative Parents Phenoxy compounds Alkyl aryl ethers Aminopyridines and derivatives Chlorobenzenes Fluorobenzenes 2-amino-1,3-thiazoles Aryl chlorides Aryl fluorides Imidolactams Heteroaromatic compounds Amino acids Carboxylic acids Azacyclic compounds Secondary amines Monocarboxylic acids and derivatives Organochlorides Organofluorides Carbonyl compounds Hydrocarbon derivatives Organopnictogen compounds Organic oxides Molecular Framework Aromatic heteromonocyclic compounds Substituents Phenoxy compound - Phenol ether - Alkyl aryl ether - Halobenzene - Aminopyridine - Fluorobenzene - Chlorobenzene - Aryl chloride - Aryl fluoride - Pyridine - Monocyclic benzene moiety - Imidolactam - Aryl halide - 1,3-thiazol-2-amine - Azole - Thiazole - Heteroaromatic compound - Amino acid - Amino acid or derivatives - Azacycle - Organoheterocyclic compound - Secondary amine - Carboxylic acid derivative - Carboxylic acid - Ether - Monocarboxylic acid or derivatives - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Amine - Organic nitrogen compound - Organooxygen compound - Organic oxide - Organonitrogen compound - Organofluoride - Hydrocarbon derivative - Organohalogen compound - Organochloride - Aromatic heteromonocyclic compound Description This compound belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility DMSO 92 mg/mL Water <1 mg/mL Ethanol <1 mg/mL Molecular Weight 461.900 g/mol XLogP3 5.400 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 8 Rotatable Bond Count 7 Exact Mass 461.098 Da Monoisotopic Mass 461.098 Da Topological Polar Surface Area 113.000 Ų Heavy Atom Count 31 Formal Charge 0 Complexity 611.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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