(S)-2-(Fmoc-amino)-4-aminobutyric acid - ≥95% , CAS No.161420-87-7

CAS: 161420-87-7 Cat. No.: F181862 Molecular Weight: 340.4 EC Number: 896-597-8

GRADE & PURITY ≥95%

Synonyms

AKOS015892808 | Butanoic acid, 4-amino-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S)- | N-alpha-Fmoc-L-2,4-diaminobutyric acid | Fmoc-L-2,4-Diaminobutyric acid | Fmoc-Dab | AM20030086 | F1225 | SCHEMBL16095188 | Fmoc-dab-oh | (S)-2-[[[(9H-Fluoren-9-y

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Synonyms

AKOS015892808 | Butanoic acid, 4-amino-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S)- | N-alpha-Fmoc-L-2, 4-diaminobutyric acid | Fmoc-L-2, 4-Diaminobutyric acid | Fmoc-Dab | AM20030086 | F1225 | SCHEMBL16095188 | Fmoc-dab-oh | (S)-2-[[[(9H-Fluoren-9-y

Specifications & Purity

≥95%

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%

Names and Identifiers

• Pubchem Sid: 504764620
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504764620
• Canonical Smiles: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CCN)C(=O)O
• IUPAC Name: (2S)-4-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid
• InChIKey: ZZDRDGKSMGGBDI-KRWDZBQOSA-N
• INCHI: 1S/C19H20N2O4/c20-10-9-17(18(22)23)21-19(24)25-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16-17H,9-11,20H2,(H,21,24)(H,22,23)/t17-/m0/s1
• Isomeric SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N[C@@H](CCN)C(=O)O
• Molecular Weight: 340.4
• Reaxy-Rn: 22125597
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22125597&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Fluorenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Fluorenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Fluorenes
• Alternative Parents: Alpha amino acids and derivatives Quaternary ammonium salts Carbamate esters Carboxylic acid salts Monocarboxylic acids and derivatives Carboxylic acids Organic zwitterions Organic salts Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Fluorene - Alpha-amino acid or derivatives - Carbamic acid ester - Quaternary ammonium salt - Carboxylic acid salt - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organic zwitterion - Primary aliphatic amine - Organic salt - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Carbonyl group - Amine - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as fluorenes. These are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Melt Point(°C): 161 °C(dec.)
• Molecular Weight: 340.400 g/mol
• XLogP3: -0.200
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 340.142 Da
• Monoisotopic Mass: 340.142 Da
• Topological Polar Surface Area: 102.000 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 462.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Lin Yi, Li Mengyao, Luo Zijin, Meng Yanan, Zong Yan, Ren Hongyu, Yu Xiaolu, Tan Xiaoqiong, Liu Fan, Wei Tuo, Cheng Qiang.  (2025)  Tissue-specific mRNA delivery and prime editing with peptide–ionizable lipid nanoparticles.  NATURE MATERIALS,      [PMID:40890498] [10.1038/s41563-025-02320-9]

2. Qiu Wang, Yi Lin, Zijin Luo, Jiahui Xiao, Keqing Xu, Xiaolu Yu, Yanan Meng, Mengyao Li, Hongyu Ren, Fan Liu, Xiaoqiong Tan, Han Wen, Tuo Wei, Qiang Cheng.  (2025)  Hydrogen Bond-Assisted Two-Component Lipid Nanoparticles for Spleen-Specific mRNA Delivery.  Journal of the American Chemical Society,      [PMID:41208607] [10.1021/jacs.5c14194]

3. Qiu Wang, Yi Lin, Jiahui Xiao, Keqing Xu, Zijin Luo, Hongyu Ren, Fan Liu, Lu Jia, Tuo Wei, Qiang Cheng.  (2026)  Optimizing Peptide Ionizable Lipids Enables Efficient and Low-Toxicity mRNA Delivery for In Vivo Prime Editing and Protein Replacement Therapy.  ADVANCED MATERIALS,      [PMID:41656866] [10.1002/adma.202522552]