(S,R,S)-AHPC-PEG₃-Alkyne - ≥95% , CAS No.2374122-30-0

CAS: 2374122-30-0 Cat. No.: S463452 Molecular Weight: 628.78 PubChem CID: 145710072

GRADE & PURITY ≥95%

Synonyms

Protein degrader building block for PROTAC research, VH032 conjugate, Crosslinker–E3 Ligase ligand conjugate, (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Description

Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

Synonyms

Protein degrader building block for PROTAC research, VH032 conjugate, Crosslinker–E3 Ligase ligand conjugate, (2S, 4R)-1-((S)-2-(tert-Butyl)-4-oxo-7, 10, 13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl

Specifications & Purity

≥95%

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%

Names and Identifiers

• Canonical Smiles: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCOCCOCCOCC#C)O
• IUPAC Name: (2S,4R)-1-[(2S)-3,3-dimethyl-2-[3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoylamino]butanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
• InChIKey: VAUAWSOCVFFOPH-UWPQIUOOSA-N
• INCHI: 1S/C32H44N4O7S/c1-6-12-41-14-16-43-17-15-42-13-11-27(38)35-29(32(3,4)5)31(40)36-20-25(37)18-26(36)30(39)33-19-23-7-9-24(10-8-23)28-22(2)34-21-44-28/h1,7-10,21,25-26,29,37H,11-20H2,2-5H3,(H,33,39)(H,35,38)/t25-,26+,29-/m1/s1
• PubChem CID: 145710072
• Molecular Weight: 628.78

Chemical and Physical Properties

• Flash Point(°F): Not applicable
• Flash Point(°C): Not applicable