VH 032 amide-PEG1-amine dihydrochloride - ≥95%(HPLC) , CAS No.2341796-83-4

CAS: 2341796-83-4 Cat. No.: V286750 Molecular Weight: 604.59 PubChem CID: 138991794

GRADE & PURITY ≥95%(HPLC)

Synonyms

VH 032 - linker 9 | (2S,4R)-1-((S)-2-(2-(2-Aminoethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

VHL ligand with PEG linker and terminal amine for onward chemistry

Specifications

Synonyms

VH 032 - linker 9 | (2S, 4R)-1-((S)-2-(2-(2-Aminoethoxy)acetamido)-3, 3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Specifications & Purity

≥95%(HPLC)

Biochemical and Physiological Mechanisms

The biochemical mechanism was changed to a functionalized von-Hippel-Lindau (VHL) protein ligand for research and development; an E3 ligase ligand and a PEG linker were incorporated to bind to the target protein ligand.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%(HPLC)

Names and Identifiers

• Pubchem Sid: 504773546
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773546
• Canonical Smiles: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)COCCN)O.Cl.Cl
• IUPAC Name: (2S,4R)-1-[(2S)-2-[[2-(2-aminoethoxy)acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;dihydrochloride
• InChIKey: DKKLDTGWCBYLGT-YEMZLKFISA-N
• INCHI: 1S/C26H37N5O5S.2ClH/c1-16-22(37-15-29-16)18-7-5-17(6-8-18)12-28-24(34)20-11-19(32)13-31(20)25(35)23(26(2,3)4)30-21(33)14-36-10-9-27;;/h5-8,15,19-20,23,32H,9-14,27H2,1-4H3,(H,28,34)(H,30,33);2*1H/t19-,20+,23-;;/m1../s1
• PubChem CID: 138991794
• Molecular Weight: 604.59