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· · COA & SDS available for every product · Same-day shipping on in-stock items Amiloride HCl dihydrate - Moligand™,≥98% , Amiloride-sensitive sodium channel, ENaC blocker, CAS No.17440-83-4, Amiloride-sensitive sodium channel, ENaC blocker
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98% Synonyms
Amilorid hydrochlorid-2-wasser | UNII-FZJ37245UC | AMILORIDE HYDROCHLORIDE [EP IMPURITY] | J-010987 | Q27105756 | Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride dihydrate | DTXSID80169826 | NSC-755847 | HMS1568A15 | 3,5
Storage
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™,≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 5 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview Amiloride HCl dihydrate is a potent epithelial sodium channel blocker.
Specifications Synonyms
Amilorid hydrochlorid-2-wasser | UNII-FZJ37245UC | AMILORIDE HYDROCHLORIDE [EP IMPURITY] | J-010987 | Q27105756 | Pyrazinecarboxamide, 3, 5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride dihydrate | DTXSID80169826 | NSC-755847 | HMS1568A15 | 3, 5
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker and selective low threshold (T-type) calcium channel protein inhibitor (KD=30μM).
Storage
Store at -20°C, Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Amiloride-sensitive sodium channel, ENaC blocker
Names and Identifiers Pubchem Sid 488184173 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488184173 Canonical Smiles C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl IUPAC Name 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;dihydrate;hydrochloride InChIKey LTKVFMLMEYCWMK-UHFFFAOYSA-N INCHI 1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2 Isomeric SMILES C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl Alternate CAS 2016-88-8；2609-46-3 Molecular Weight 302.12 Reaxy-Rn 24940064 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24940064&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Diazines Subclass Pyrazines Intermediate Tree Nodes Not available Direct Parent Aminopyrazines Alternative Parents Imidolactams Aryl chlorides Heteroaromatic compounds Propargyl-type 1,3-dipolar organic compounds Carboximidamides Azacyclic compounds Primary amines Organopnictogen compounds Organooxygen compounds Organochlorides Organic oxides Imines Hydrochlorides Hydrocarbon derivatives Molecular Framework Aromatic heteromonocyclic compounds Substituents Aminopyrazine - Aryl chloride - Aryl halide - Imidolactam - Heteroaromatic compound - Carboximidamide - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Azacycle - Organic nitrogen compound - Amine - Primary amine - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Imine - Organopnictogen compound - Organic oxide - Hydrochloride - Organic oxygen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound Description This compound belongs to the class of organic compounds known as aminopyrazines. These are organic compounds containing an amino group attached to a pyrazine ring. External Descriptors hydrate Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Soluble in water (1 mg/ml, warm), DMSO (60 mg/ml at 25 °C), and ethanol (< 1 mg/ml at 25 °C). Sensitivity Moisture sensitive Melt Point(°C) 293.5°C Molecular Weight 302.120 g/mol XLogP3 Hydrogen Bond Donor Count 7 Hydrogen Bond Acceptor Count 7 Rotatable Bond Count 1 Exact Mass 301.046 Da Monoisotopic Mass 301.046 Da Topological Polar Surface Area 161.000 Ų Heavy Atom Count 18 Formal Charge 0 Complexity 279.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 4
Documents & Articles Citations of This Product References 1. Siying Chen, Zhicheng Le, Jiayue Gu, Lixin Liu, Zhijia Liu, Yongming Chen. (2023) Exploring the Effect of Amphiphile Architecture on Intracellular Protein Delivery Capacity: Dimeric versus Trimeric Amphiphiles. ACS Applied Materials & Interfaces, [PMID:37219911 ] [10.1021/acsami.3c02198 ] 2. Shengnan Ma, Lei Song, Yueyue Bai, Shihao Wang, Jiao Wang, Haohao Zhang, Fazhan Wang, Yiyan He, Chuntao Tian, Guijun Qin. (2023) Improved intracellular delivery of exosomes by surface modification with fluorinated peptide dendrimers for promoting angiogenesis and migration of HUVECs. RSC Advances, 13 (17): (11269-11277). [PMID:37057265 ] [10.1039/D3RA00300K ] 3. Gege Zeng, Zepeng He, Haihong Yang, Zhan Gao, Xueer Ge, Lixin Liu, Zhijia Liu, Yongming Chen. (2024) Cationic Lipid Pairs Enhance Liver-to-Lung Tropism of Lipid Nanoparticles for In Vivo mRNA Delivery. ACS Applied Materials & Interfaces, [PMID:38717294 ] [10.1021/acsami.4c02415 ] 4. Yang Chen, Wenzhe Xu, Hao Jin, Mengsi Zhang, Shuwei Liu, Yi Liu, Hao Zhang. (2024) Nutritional Glutamine-Modified Iron-Delivery System with Enhanced Endocytosis for Ferroptosis Therapy of Pancreatic Tumors. ACS Nano, [PMID:39512234 ] [10.1021/acsnano.4c08083 ] 5. Dao-Lai Zhang, Yu-Jing Sun, Ming-Liang Ma, Yi-jing Wang, Hui Lin, Rui-Rui Li, Zong-Lai Liang, Yuan Gao, Zhao Yang, Dong-Fang He, Amy Lin, Hui Mo, Yu-Jing Lu, Meng-Jing Li, Wei Kong, Ka Young Chung, Fan Yi, Jian-Yuan Li, Ying-Ying Qin, Jingxin Li, Alex R B Thomsen, Alem W Kahsai, Zi-Jiang Chen, Zhi-Gang Xu, Mingyao Liu, Dali Li, Xiao Yu, Jin-Peng Sun. (2018) Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility. eLife, [PMID:29393851 ] [10.7554/eLife.33432 ]
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