Experiments on the preparation of colloidal solution-type liquid pharmaceuticals
Experiments on the preparation of colloidal solution-type liquid pharmaceuticals
Colloidal solution type liquid pharmaceuticals according to the classification of the dispersion system, including two categories: a class of polymer solutions belonging to the molecular (or ionic) dispersion system. Such as sodium carboxymethyl cellulose, western yarrow gum, gum Arabic, agar, hyacinth gum and other gels, as well as pepsin, gelatin and other protein solutions, the other belongs to the particles (polymer aggregates) dispersion system of colloidal solutions. Such as silver oxide sol, iron hydroxide sol, as well as by the surfactant as a solubilizer of certain solutions (such as cresol soap solution), etc..
Operation method
colloidal method
Principle
Colloidal solution type liquid pharmaceuticals according to the classification of the dispersion system, including two categories: a class of polymer solutions belonging to the molecular (or ionic) dispersion system. Such as sodium carboxymethyl cellulose, western yarrow gum, gum Arabic, agar, hyacinth gum and other gels, as well as pepsin, gelatin and other protein solutions, the other belongs to the particles (multimolecular aggregates) dispersion system of colloidal solutions. Such as silver oxide sol, iron hydroxide sol, as well as by the surfactant as a solubilizer of certain solutions (such as cresol soap solution), etc.. As the colloidal point of mass between the true solution and suspension, so colloidal solution has both some of the properties of the solution, but also has some of the properties of the suspension; but colloidal solution is different from the true solution, but also different from the suspension, which has its own unique properties. Colloidal solution type liquid pharmaceutical solvent is mostly water, but also ethanol, ether, acetone and other non-aqueous solvents. According to the affinity between the colloid and the solvent, colloids can be divided into hydrophilic (or hydrophilic) colloids and hydrophobic (or hydrophobic) colloids. Commonly used for hydrophilic colloid solution.
Materials and Instruments
Vegetable oil Ferric ammonium citrate Move I. Preparation of Pepsin Compound For more product details, please visit Aladdin Scientific website.
Pepsin Hydrochloric acid Tincture of orange peel Ethyl alcohol Simple syrup Benzoic acid Astragali gum Distilled water Cresol Sodium hydroxide Sodium hydroxide Edible flavors Hydroxybenzene ethyl ester solution
Beaker Brinell's Filter Hopper Filter Paper Dryer
1. Prescription
Pepsin (1:3 000) 20 gDilute hydrochloric acid 20 mlTincture of orange peel 50 mlSimple syrup 100 mlBenzoic acid 2 gDistilled water Add to 100 ml
2. Method of preparation
Take benzoic acid dissolved in orange peel tincture, slowly add about 800 ml of water, stir well, and add syrup and dilute hydrochloric acid, stir well, and then spread the pepsin in the liquid, so that it is naturally immersed in the natural, and then gently stir to make the dissolution of the water, add water to the full amount, stir well, that is, obtained.
3. Notes
(1) The activity of pepsin is required to be between pH 1.5-2.5, too high or too low reduces the activity or completely inactivates. Therefore, dilute hydrochloric acid must be diluted first.
(2) Pepsin is a colloidal substance, when dissolved, it should be spread on the surface of the liquid, so that it fully absorbs water and swells, and then slowly stirred, the temperature is too high (40 ℃ or so) is easy to inactivate, so it is not advisable to use hot water.
(3) This product is affected by a variety of factors in storage, easy to reduce or disappear activity, should not be stored for a long time, should not be a large number of preparations, should not be shaken violently.
(4) The digestive power of pepsin used in this prescription is 1:3000, and should be discounted if other specifications are used. This product is a digestive aid. Pepsin is a kind of digestive enzyme, which can make protein decompose into peptone. Because of its digestive power to pH 1.5 ~ 2.5 when the strongest, it is often used in conjunction with dilute hydrochloric acid. Tincture of orange peel is an aromatic bitter stomachic medicine, which is both an aromatic flavoring agent and has certain stomachic effect. Simple syrup is a corrective agent. This product is mainly used for indigestion caused by eating too much protein food, as well as post-disease recovery period of impaired digestive function and so on.
II. Preparation of cresol soap solution
1. Prescription
Cresol 500 mlVegetable oil 173 gSodium hydroxide 27 gDistilled water Add to 1 000 ml
2. Method of preparation
Take sodium hydroxide with water 100 ml dissolved, add vegetable oil in water soluble in heating until saponification is complete, take 1 drop of solution with 9 drops of water without oil droplets precipitation, that is, saponification is complete, while hot, add cresol stirring to make the dissolution of clarification, and then add water to the amount.
3. Notes
(1) The sodium soap produced in the prescription may be replaced by potassium soap.
(2) A small amount of ethanol can be added during the saponification process to accelerate the saponification reaction.
III. Preparation of ferric ammonium citrate combination
1. Prescription
Ferric ammonium citrate 100 gSimple syrup 200 mlFood flavorings, moderate amountEthyl hydroxyphenyl ester solution (5%) 10 mlPurified water added to 1 000 ml
2. Method of preparation
Take ethyl hydroxyphenyl ester solution (5%) and slowly add about 700 ml of purified water, stir as you add, take ferric ammonium citrate and sprinkle it on the above liquid surface in several times, then stir to dissolve, add edible flavor, simple syrup and stir, then add purified water to make 1,000 ml, stir, that is, obtained.
3. Cautions
(1) Ferric ammonium citrate is a colloidal compound and should be dispersed on the surface of the liquid in stages. Let it dissolve naturally or stir it slightly to accelerate the dissolution. Do not add water directly and stir to dissolve, so as not to form lumps and affect the dissolution.
(2) This product should not be heated to promote solubilization or filtered. It should be freshly prepared and should not be stored for a long time to avoid decomposition of ferric ammonium citrate.
(3) This product is easily deteriorated by light, so it should be packaged with light shielding.
4. Quality requirements
(1) This product is a brownish red colloid with a ferruginous odor.
(2) This product contains ferric ammonium citrate should be 1.66%~1.84% (g/ml) in terms of iron (Fe).
5. Notes
(1) Commercially available ferric ammonium citrate is available in green and brownish-red, and the medicinal product is synthesized in red; the green product is not available for medicinal use.
(2) Avoid drinking tea while taking this product and do not take it with tetracycline antibiotics.
IV. Preparation of 2.5% West Astragalus Gum Paste
1. Prescription
Western Astragalus Gum (No.7 powder) 2.5 gBenzoic acid 0.2 gEthanol 2.5 mlDistilled water 100.0 ml
2. Method of preparation
Take the western astragalus gum and benzoic acid with dry wide-mouth bottle, add ethanol shaking, and then once add appropriate amount of distilled water to make 100 ml, shaking vigorously, that is obtained.
3. Notes
(1) Ethanol is used as a dispersant, and the glue powder is wetted first.
(2) Benzoic acid as a preservative to prevent mold failure.
V. Preparation of sodium carboxymethyl cellulose mortar
1. Prescription
Sodium carboxymethyl cellulose 25 gGlycerin 300 mlHydroxyphenyl ethyl ester solution (5%) 20 mlFlavor Moderate amountPurified waterTotal 1,000 ml
2. Method of preparation
Take sodium carboxymethyl cellulose and add it into 500 ml hot purified water in several times, stir gently to make it dissolve, then add glycerol, hydroxyphenethyl ester solution (5%), flavor, and finally add purified water to 1000 ml, stir well, that is to obtain.
3. Role and utility
This product is a lubricant, used for lubrication during cavity and instrument examination or anal examination.
4. Usage and dosage
Apply an appropriate amount of this product to the surface or tip of the instrument.
5. Notes
(1) Sodium carboxymethyl cellulose is white fibrous powder or granule, odorless, can be dissolved in cold and hot water, but dissolves slowly in cold water, insoluble in general organic solvents. Preparation, sodium carboxymethyl cellulose, such as a small amount of ethanol first wet, and then dissolved according to the above method is more convenient.
(2) Sodium carboxymethyl cellulose can precipitate when encountering cationic drugs, alkaline earth metals and heavy metal salts, so it cannot use quaternary ammonium salts and mercury preservatives.
(3) The product has the highest viscosity at pH 5-7, and the viscosity decreases rapidly when the pH is lower than 5 or higher than 10, and the pH is generally 6-8.
(4) Glycerin acts as a moisturizer, thickener and lubricant.
VI. Preparation of electrocardiographic conductive adhesive
1. Prescription
Sodium chloride 180 gStarch 100 gGlycerin 200 gHydroxyphenyl ethyl ester solution (5%) 6 mlPurified water Adequate amountTotal 1,000 ml
2. Method of preparation
Take sodium chloride dissolved in appropriate amount of water, add hydroxyphenethyl ester solution (5%) heated to boiling; another take starch with a small amount of cold water to mix, the above sodium chloride solution while hot and slowly added to make a paste, add glycerol, and then add water to make 1000 ml, stir well, divided, that is, obtained.
3. Role and utility
For conducting electrodes during ECG and EEG examinations.
4. Usage and dosage
Apply topically.
5. Notes
This product is a colorless viscous liquid with fluidity. It should be kept tightly closed.