N,N'-Bis(3-aminopropyl)-1,4-butanediamine Tetrahydrochloride - ≥98%(T) , CAS No.306-67-2

CAS: 306-67-2 Cat. No.: N159137 Molecular Weight: 348.18 EC Number: 206-189-8 PubChem CID: 9384

GRADE & PURITY ≥98%(T)

Synonyms

N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride | Gerontine tetrahydrochloride | Musculamine tetrahydrochloride | N1,N1'-(Butane-1,4-diyl)bis(propane-1,3-diamine) tetrahydrochloride | Spermine tetrahydrochloride | Neuridine tetrahydrochloride

Storage

Argon charged,Room temperature

Shipped In

Normal

Specifications

Synonyms

N, N'-Bis(3-aminopropyl)-1, 4-butanediamine tetrahydrochloride | Gerontine tetrahydrochloride | Musculamine tetrahydrochloride | N1, N1'-(Butane-1, 4-diyl)bis(propane-1, 3-diamine) tetrahydrochloride | Spermine tetrahydrochloride | Neuridine tetrahydrochloride

Specifications & Purity

≥98%(T)

Biochemical and Physiological Mechanisms

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine

Storage

Argon charged, Room temperature

Shipped In

Normal

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%(T)

Names and Identifiers

• Pubchem Sid: 504751830
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504751830
• Canonical Smiles: C(CCNCCCN)CNCCCN.Cl.Cl.Cl.Cl
• IUPAC Name: N,N'-bis(3-aminopropyl)butane-1,4-diamine;tetrahydrochloride
• InChIKey: XLDKUDAXZWHPFH-UHFFFAOYSA-N
• INCHI: 1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
• Isomeric SMILES: C(CCNCCCN)CNCCCN.Cl.Cl.Cl.Cl
• WGK Germany: 3
• RTECS: EJ7230000
• Alternate CAS: 1255099-40-1
• PubChem CID: 9384
• Molecular Weight: 348.18
• Reaxy-Rn: 3911771

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Class Organonitrogen compounds
      • Subclass Amines
        • Level5 Secondary amines
          • Level6 Dialkylamines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Class: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Secondary amines
• Direct Parent: Dialkylamines
• Alternative Parents: Organopnictogen compounds Monoalkylamines Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Secondary aliphatic amine - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Primary amine - Primary aliphatic amine - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as dialkylamines. These are organic compounds containing a dialkylamine group, characterized by two alkyl groups bonded to the amino nitrogen.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

Discover Target: PMP22

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

nfo Endonuclease 4 (425 Activities)

Discover Target: nfo

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water (348.2 g/L at 20°C).
• Sensitivity: Hygroscopic
• Melt Point(°C): 315°C
• Molecular Weight: 348.200 g/mol
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 11
• Exact Mass: 348.12 Da
• Monoisotopic Mass: 346.122 Da
• Topological Polar Surface Area: 76.100 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 86.100
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 5

XLogP3

References

1. Shijin Xiong, Xiaoyan Xu, Qiaozhen Liu, Yazhou Xu, Hongbing Ren, Tao Xiong, Mingyong Xie.  (2023)  Integrated metatranscriptomics and metabolomics revealed the metabolic pathways of biogenic amines during Laotan Suancai fermentation.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2023.103517]

2. Yu Wang, Xueping Kong, Fei Li, Bao Li, Lixin Wu, Kai Chen, Yuqing Wu.  (2022)  Mo154 Synergistically Enhanced Antibiofilm and Antibacterial Effects of Spermine via Coassembly.  ACS Applied Bio Materials,      [PMID:36264761] [10.1021/acsabm.2c00692]

3. Yanan Liu, Yuhao Huang, Qileng Aori, Yu Wang, Sai Zhao, Zhen-Lin Xu.  (2026)  A sustained-release antibacterial gelatin hydrogel based on metal-phenolic networks for long-term preservation of prefabricated meat.  FOOD CHEMISTRY,      [PMID:] [10.1016/j.foodchem.2026.149080]