10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Fluvastatin (XU-62-320) Sodium Fluvastatin Sodium (XU-62-320) inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.
In vitro
Fluvastatin markedly inhibits the formation of thiobarbituric acid reactive substances in iron (II)-supported peroxidation of liposomes with IC50 of 12 μM. Fluvastatin ranging from 1 μM to 100 μM inhibits peroxyl radical-mediated peroxidation of liposomes induced by water-soluble and lipid-soluble radical generators, 2,2\'-azobis (2-amidinopropane) dihydro-chloride and 2,2\'-azobis (2,4-dimethylvaleronitrile), respectively. Fluvastatin (4 mM) and its metabolites shows superoxide anion scavenging activity in the hypoxanthine-xanthine oxidase system and a strong scavenging effect on the hydroxyl radical produced from Fenton\'s reaction. Fluvastatin (8 μM) and its metabolites shows protective effects on DNA damage as potent as the reference antioxidants, ascorbic acid, trolox, and probucol in CHL/IU cells. Fluvastatin (100 nM) shows a dose-dependent decrease in Ang II-activated superoxide anion formation in human aortic smooth muscle cells (hASMC).
In vivo
Fluvastatin (10 mg/kg/day) results in a decrease in serum lipids in rabbits feed a 1.5% cholesterol containing diet. Fluvastatin (10 mg/kg/day) significantly lowers the tissue ACE in the aortae in rabbits feed a 1.5% cholesterol containing diet. Fluvastatin (10 mg/kg/day) significantly reverses the suppression of ACh-induced relaxation in rabbits feed a 1.5% cholesterol containing diet.
Cell Data
cell lines：HL-60 cells
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomeric SMILES | CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@H](CC(=O)[O-])O)O)C3=CC=C(C=C3)F.[Na+] |
|---|---|
| RTECS | MJ9675100 |
| PubChem CID | 23663976 |
| Molecular Weight | 433.45 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubility | Solubility (25°C) In vitro |
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| 1. Tingting Liu, Fanyu Yang, Liming Wang, Liang Pei, Yushan Hu, Ru Li, Kang Hou, Tianlong Ren. (2022) Synergistic Effect of Charge Separation and Multiple Reactive Oxygen Species Generation on Boosting Photocatalytic Degradation of Fluvastatin by ZnIn2S4/Bi2WO6 Z-Scheme Heterostructured Photocatalytst. Toxics, 10 (10): (555). [PMID:36287836] [10.3390/toxics10100555] |
| 2. Tingting Liu, Lei Wang, Xiu Liu, Chenxu Sun, Yongtao Lv, Rui Miao, Xudong Wang. (2019) Dynamic photocatalytic membrane coated with ZnIn2S4 for enhanced photocatalytic performance and antifouling property. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2019.122379] |
