Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Moligand™,≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature,Desiccated Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 29 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Isatin is an endogenous monoamine oxidase (MAO) inhibitor involved in stress and anxiety. Additionally, isatin inhibits alkaline phosphatase (ALP), nitric oxide (NO)-stimulated soluble guanylate cyclase, and other enzymes.
An endogenous monoamine oxidase inhibitor.
Application:
Isatin can be used as a reactant to prepare:
Phthalazinone derivatives.
Spirooxindole derivatives.
Agents against multidrug-resistant cells expressing P-glycoprotein.
Thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.
Triazole-isatine compounds as potential antibacterial and antifungal agents.
Biologically relevant scaffolds such as spiro[indole-thiazolidinones].
It can be a reactant for:
Cascade reactions with heterocyclic ketene aminals.
Knoevenagel condensation reactions.
Isatin can also be used as a chromatographic spray reagent for amino acids, and also as a reference material in the preparation of indigo and Maya Blue. It is responsible for the yellow color exhibited by the "Maya Yellow" pigment.
Isatin undergoes Pd(II)-catalyzed C-H addition by direct sp2/sp3 C-H bond activation to form 3-substituted-3-hydroxy-2-oxindoles. Isatin derivatives (bis-Schiff base) are synthesized by the condensation of the natural or synthetic isatins with hydrazine.
| Pubchem Sid | 504751236 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504751236 |
| Canonical Smiles | C1=CC=C2C(=C1)C(=O)C(=O)N2 |
| IUPAC Name | 1H-indole-2,3-dione |
| InChIKey | JXDYKVIHCLTXOP-UHFFFAOYSA-N |
| INCHI | 1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11) |
| Isomeric SMILES | C1=CC=C2C(=C1)C(=O)C(=O)N2 |
| WGK Germany | 1 |
| RTECS | NL7873000 |
| Molecular Weight | 147.13 |
| Beilstein | 383659 |
| Reaxy-Rn | 383659 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=383659&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Indoles and derivatives |
| Subclass | Indolines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Indolines |
| Alternative Parents | Aryl ketones Benzenoids Vinylogous amides Secondary carboxylic acid amides Lactams Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Dihydroindole - Aryl ketone - Benzenoid - Vinylogous amide - Carboxamide group - Ketone - Lactam - Secondary carboxylic acid amide - Carboxylic acid derivative - Azacycle - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Carbonyl group - Organic nitrogen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as indolines. These are compounds containing an indole moiety, which consists of pyrrolidine ring fused to benzene to form 2,3-dihydroindole. |
| External Descriptors | a small molecule |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jun 11, 2026 | I104665 | |
| Certificate of Analysis | Mar 20, 2026 | I104665 | |
| Certificate of Analysis | Mar 20, 2026 | I104665 | |
| Certificate of Analysis | Mar 20, 2026 | I104665 | |
| Certificate of Analysis | Jan 04, 2026 | I104665 | |
| Certificate of Analysis | Sep 09, 2025 | I104665 | |
| Certificate of Analysis | Sep 09, 2025 | I104665 | |
| Certificate of Analysis | Sep 09, 2025 | I104665 | |
| Certificate of Analysis | Sep 08, 2025 | I104665 | |
| Certificate of Analysis | Sep 08, 2025 | I104665 | |
| Certificate of Analysis | Sep 08, 2025 | I104665 | |
| Certificate of Analysis | Nov 15, 2024 | I104665 | |
| Certificate of Analysis | Aug 16, 2024 | I104665 | |
| Certificate of Analysis | Jul 03, 2024 | I104665 | |
| Certificate of Analysis | Jul 03, 2024 | I104665 | |
| Certificate of Analysis | Jul 03, 2024 | I104665 | |
| Certificate of Analysis | Jul 03, 2024 | I104665 | |
| Certificate of Analysis | Jul 07, 2022 | I104665 | |
| Certificate of Analysis | Jul 07, 2022 | I104665 | |
| Certificate of Analysis | Jul 07, 2022 | I104665 | |
| Certificate of Analysis | Jul 07, 2022 | I104665 | |
| Certificate of Analysis | Oct 18, 2021 | I104665 | |
| Certificate of Analysis | Oct 18, 2021 | I104665 |
| Solubility | Soluble in water (1.9 g/l at 20 °C). |
|---|---|
| Flash Point(°F) | 428 ℉ |
| Flash Point(°C) | 220°C |
| Melt Point(°C) | 203.5°C |
| Molecular Weight | 147.130 g/mol |
| XLogP3 | 0.800 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 0 |
| Exact Mass | 147.032 Da |
| Monoisotopic Mass | 147.032 Da |
| Topological Polar Surface Area | 46.200 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 212.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Qian Wang, Lei Huang, Jiayu Guan, Linjian Sang, Jifu Zheng, Qifeng Zhang, Guorui Qin, Shenghai Li, Suobo Zhang. (2023) Side chain sulfonic acid polymers with intrinsic pores in the main chain as proton exchange membranes for fuel cells and redox flow battery. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2023.122036] |
| 2. Hukang Guo, Fupeng Li, Xuerong Shui, Jianyu Wang, Chuanjie Fang, Liping Zhu. (2023) Ultrathin Polyamide Nanofilms with Controlled Microporosity for Enhanced Solvent Permeation. ACS Applied Materials & Interfaces, [PMID:37479673] [10.1021/acsami.3c07440] |
| 3. Sisheng Fang, Hai Tang, Meng Wang, Zhaozan Xu, Nanwen Li. (2023) The antifouling and separation performance of an ultrafiltration membrane derived from a novel amphiphilic copolymer containing a crown ether. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2023.121620] |
| 4. Jiangru Wang, Yan Yang, Qirui Shen, Dazhong Shen, Qi Kang. (2023) A smartphone-based long optical path colorimetric turntable for selective determination of malachite green and investigation the specific adsorption behavior of the imprinted cavities within molecularly imprinted polymers. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2023.108629] |
| 5. Yanqing Li, Yingwu Lin, Fang Wang, Jinghan Wang, Osami Shoji, Jiakun Xu. (2023) Construction of Biocatalysts Using the P450 Scaffold for the Synthesis of Indigo from Indole. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (3): (2395). [PMID:36768714] [10.3390/ijms24032395] |
| 6. Qian Wang, Lei Huang, Zimo Wang, Jifu Zheng, Qifeng Zhang, Guorui Qin, Shenghai Li, Suobo Zhang. (2022) High Conductive Anion Exchange Membranes from All-Carbon Twisted Intrinsic Microporous Polymers. MACROMOLECULES, [PMID:] [10.1021/acs.macromol.2c01874] |
| 7. Qing Fang, Qin Liu, Zongli Xie, Matthew R. Hill, Kaisong Zhang. (2022) Two dimensional laminar MoS2 modified PTMSP membranes with improved organic solvent nanofiltration performance. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2022.121139] |
| 8. Hukang Guo, Xiaoyi Xu, Jiaqi Li, Weilin Feng, Mengxiao Zhang, Chuanjie Fang, Liping Zhu. (2022) Chemically tailored microporous nanocomposite membranes with multi-channels for intensified solvent permeation. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2022.120877] |
| 9. Tuo Zhao, Chuan Long, Zhiqian Wang, Hong Zhu. (2021) Multication Cross-Linked Poly(p-terphenyl isatin) Anion Exchange Membranes for Fuel Cells: Effect of Cross-Linker Length on Membrane Performance. ACS Applied Energy Materials, [PMID:] [10.1021/acsaem.1c03153] |
| 10. Weilin Feng, Jiaqi Li, Chuanjie Fang, Lin Zhang, Liping Zhu. (2021) Controllable thermal annealing of polyimide membranes for highly-precise organic solvent nanofiltration. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2021.120013] |
| 11. Yongjiang Yuan, Xinming Du, Hongyu Zhang, Hui Wang, Zhe Wang. (2021) Poly (isatin biphenylene) polymer containing ferrocenium derivatives for anion exchange membrane fuel cell. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2021.119986] |
| 12. Zhao Shuxue, Chen Xi, Sun Qianshu, Wang Fei, Hu Chunhui, Guo Lizhong, Bai Jie, Yu Hao. (2021) Label-Free Quantitative Proteomic Analysis of the Global Response to Indole-3-Acetic Acid in Newly Isolated Pseudomonas sp. Strain LY1. Frontiers in Microbiology, [PMID:34447357] [10.3389/fmicb.2021.694874] |
| 13. Ziqin Li, Riming Yu, Chang Liu, Jifu Zheng, Jing Guo, Tauqir A. Sherazi, Shenghai Li, Suobo Zhang. (2021) Preparation and characterization of side-chain poly(aryl ether ketone) anion exchange membranes by superacid-catalyzed reaction. POLYMER, [PMID:] [10.1016/j.polymer.2021.123639] |
| 14. Ziqin Li, Jing Guo, Jifu Zheng, Tauqir A. Sherazi, Shenghai Li, Suobo Zhang. (2020) A Microporous Polymer with Suspended Cations for Anion Exchange Membrane Fuel Cells. MACROMOLECULES, [PMID:] [10.1021/acs.macromol.0c01948] |
| 15. Jiaqi Li, Mengxiao Zhang, Weilin Feng, Liping Zhu, Lin Zhang. (2020) PIM-1 pore-filled thin film composite membranes for tunable organic solvent nanofiltration. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2020.117951] |
| 16. Yanjuan Gao, Guoying Wang, Aijuan Zhou, Xiuping Yue, Yanqing Duan, Xin Kong, Xiao Zhang. (2019) Effect of nitrate on indole degradation characteristics and methanogenesis under mixed denitrification and methanogenesis culture. BIOCHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.bej.2019.02.009] |
| 17. Chun-Er Lin, Ming-Yong Zhou, Wei-Song Hung, Bao-Ku Zhu, Kueir-Rarn Lee, Li-Ping Zhu, Li-Feng Fang. (2018) Ultrathin nanofilm with tailored pore size fabricated by metal-phenolic network for precise and rapid molecular separation. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2018.06.077] |
| 18. Cuiling Wang, Jiaxu Yan, Mo Du, Joseph A. Burlison, Chi Li, Yanni Sun, Danqing Zhao, Jianli Liu. (2017) One step synthesis of indirubins by reductive coupling of isatins with KBH4. TETRAHEDRON, [PMID:] [10.1016/j.tet.2017.03.077] |
| 19. Jin-Qiang Liu, Si-Yu Chen, Baoming Ji. (2014) Solubility and Thermodynamic Functions of Isatin in Pure Solvents. JOURNAL OF CHEMICAL AND ENGINEERING DATA, [PMID:] [10.1021/je500396b] |
| 20. Bin Yu, Ping-Ping Qi, Xiao-Jing Shi, Li-Hong Shan, De-Quan Yu, Hong-Min Liu. (2014) Discovery of novel steroidal pyran–oxindole hybrids as cytotoxic agents. STEROIDS, [PMID:24928731] [10.1016/j.steroids.2014.05.022] |
| 21. Zhao Xiao-Ting, Li Wen-Dian, Tao Fei-Yan, Wang Na. (2024) Cysteine Catalyzed Pictet-Spengler Reaction: a Convenient and Mild Method for Synthesis of Spiroindolones. CATALYSIS LETTERS, [PMID:] [10.1007/s10562-024-04698-8] |
| 22. Qian Wang, Linjian Sang, Lei Huang, Jiayu Guan, Huiting Yu, Jifu Zheng, Qifeng Zhang, Guorui Qin, Shenghai Li, Suobo Zhang. (2024) Design and Synthesis of Comb-Like Bisulfonic Acid Proton Exchange Membrane with Regulated Microstructure. ADVANCED FUNCTIONAL MATERIALS, [PMID:] [10.1002/adfm.202316506] |
| 23. Hongjing Li, Min Liu, Bin Hu, Xu Hu, Meizi He, Junhao Xin, Chengyuan Niu, Yingda Huang, Nanwen Li, Zushun Xu, Quanyuan Zhang. (2024) High chemical stability poly(oxindole biphenylene)/ZrO2 porous separator for alkaline water electrolysis. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2024.122658] |
| 24. Shuang Guo, Chuanjie Fang, Jiaqi Li, Yongbing Zhuang, Liping Zhu. (2024) Intrinsically microporous polyimide membranes with synergistic aromatic and alicyclic linking groups for efficient molecular separation. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2024.127530] |
| 25. Yijia Lei, Jialin Zhao, Jian Gao, Jingyi Wu, Na Li, Xiaoyu Chi, Yan Wang, Yiman Gu, Zhe Wang. (2024) Robust branched Poly(p-terphenyl isatin) anion exchange membranes with enhanced microphase separation structure for fuel cells. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2024.123368] |
| 26. Jialin Zhao, Jian Gao, Yijia Lei, Shiyao Sun, Jingyi Wu, Na Li, Jiahao Lu, Yifang Chang, Jiayao Yang, Zhe Wang. (2024) Synergistic Effect of Localized Three-Dimensional Polymer Backbone and Self-Assembling Cation for the Construction of Novel Anion Exchange Membrane. MACROMOLECULES, [PMID:] [10.1021/acs.macromol.4c02084] |
| 27. Weilin Feng, Lu Xu, Yuji Chen, Jiaqi Li, Hukang Guo, Mengxiao Zhang, Xiaohe Wang, Jianyu Wang, Chuanjie Fang, Liping Zhu. (2024) Thermal-induced surface densification of polyimide asymmetrical membranes for efficient organic solvent nanofiltration. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2024.126560] |
| 28. Fupeng Li, Jiaqi Li, Hukang Guo, Weilin Feng, Jianyu Wang, Chuanjie Fang, Liping Zhu. (2024) Ultramicroporous cardo-pendant polyamide nanofilms for enhanced organic solvent nanofiltration. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2024.122879] |
| 29. Chi Jiang, Yan Liu, Shan Yang, Xin Zhang, Ming Wang, Deqing Shi, Xinliang Liu, Yingfei Hou. (2026) Dual-structure, dual-function mixed matrix membrane for alkaline water electrolysis. INTERNATIONAL JOURNAL OF HYDROGEN ENERGY, [PMID:] [10.1016/j.ijhydene.2026.154383] |
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