Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 32 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Lincomycin is a polar, water soluble, broad spectrum antibiotic first isolated from|Streptomyces licolnensis|by researchers at Upjohn in 1962. Lincomycin was the first of a unique structural class, the lincosamides, containing a rare amino acid, 4-propyl-N- methylproline, coupled to an equally rare aminomethylthio- octopyranoside sugar. Lincomycin and semi-synthetic analogues are often incorrectly considered to be aminoglycosides but share little or no structural similarity. Lincomycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.
| pKa | pKₐ: 12.91 (Predicted), pKₐ: 8.78 (Predicted) |
|---|---|
| ALogP | 0.2 |
| Canonical Smiles | CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O |
|---|---|
| IUPAC Name | (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide |
| InChIKey | OJMMVQQUTAEWLP-KIDUDLJLSA-N |
| INCHI | 1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12-,13+,14-,15-,16-,18-/m1/s1 |
| Isomeric SMILES | CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@@H](C)O |
| RTECS | RH6314000 |
| Alternate CAS | 7179-49-9 |
| Molecular Weight | 406.54 |
| Beilstein | 707677 |
| Reaxy-Rn | 24730829 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24730829&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Class | Carboxylic acids and derivatives |
| Subclass | Amino acids, peptides, and analogues |
| Intermediate Tree Nodes | Amino acids and derivatives - Alpha amino acids and derivatives |
| Direct Parent | Proline and derivatives |
| Alternative Parents | Alpha amino acid amides Thioglycosides Pyrrolidinecarboxamides Monosaccharides N-alkylpyrrolidines Oxanes Monothioacetals Trialkylamines Secondary carboxylic acid amides Secondary alcohols Azacyclic compounds Sulfenyl compounds Oxacyclic compounds Polyols Organic oxides Carbonyl compounds Hydrocarbon derivatives Organopnictogen compounds |
| Molecular Framework | Aliphatic heteromonocyclic compounds |
| Substituents | Proline or derivatives - Alpha-amino acid amide - Glycosyl compound - S-glycosyl compound - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - Monosaccharide - Oxane - N-alkylpyrrolidine - Monothioacetal - Pyrrolidine - Tertiary aliphatic amine - Tertiary amine - Secondary carboxylic acid amide - Secondary alcohol - Carboxamide group - Azacycle - Organoheterocyclic compound - Oxacycle - Sulfenyl compound - Polyol - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Alcohol - Organopnictogen compound - Organic oxygen compound - Organic oxide - Carbonyl group - Amine - Organic nitrogen compound - Aliphatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as proline and derivatives. These are compounds containing proline or a derivative thereof resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. |
| External Descriptors | monocarboxylic acid amide - pyrrolidinecarboxamide - L-proline derivative - carbohydrate-containing antibiotic - S-glycosyl compound |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Mar 11, 2024 | L329314 | |
| Certificate of Analysis | Mar 11, 2024 | L329314 | |
| Certificate of Analysis | Mar 11, 2024 | L329314 | |
| Certificate of Analysis | Mar 11, 2024 | L329314 | |
| Certificate of Analysis | Mar 11, 2024 | L329314 | |
| Certificate of Analysis | Mar 11, 2024 | L329314 | |
| Certificate of Analysis | Mar 11, 2024 | L329314 | |
| Certificate of Analysis | Mar 11, 2024 | L329314 | |
| Certificate of Analysis | Mar 11, 2024 | L329314 |
| Solubility | Soluble in ethanol, methanol, DMF, DMSO, and water. |
|---|---|
| Sensitivity | Moisture sensitive |
| Refractive Index | n20D1.58 (Predicted) |
| Boil Point(°C) | ~646.8° C at 760 mmHg (Predicted) |
| Melt Point(°C) | 262.24° C (Predicted) |
| Molecular Weight | 406.500 g/mol |
| XLogP3 | 0.200 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 7 |
| Exact Mass | 406.214 Da |
| Monoisotopic Mass | 406.214 Da |
| Topological Polar Surface Area | 148.000 Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 498.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 9 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Junhua Chen, Gu Shi, Chong Yan. (2023) Portable biosensor for on-site detection of kanamycin in water samples based on CRISPR-Cas12a and an off-the-shelf glucometer. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:36801336] [10.1016/j.scitotenv.2023.162279] |
| 2. Dan Liu, Jiahui Ji, Xinran Guo, Sanhu Gou, Xinyue Chen. (2023) Syringe Paper-Based Analytical Device for Thiamazole Detection by Hedysarum Polysaccharides-Mediated Silver Nanoparticles. Micromachines, 14 (2): (350). [PMID:36838050] [10.3390/mi14020350] |
| 3. Tingting Liu, Xiaocui Lai, Ping Guo, Wei Zhang, Gan Zhang, Mengyun Wu, Guangjian Xue, Xuechen Fang, Juan Peng, Weihua Lai. (2023) Sensitive lateral flow immunoassay strips based on Fe3+-chelated polydopamine nanospheres for the detection of kanamycin. FOOD CHEMISTRY, [PMID:36701914] [10.1016/j.foodchem.2023.135511] |
| 4. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] [10.1016/j.mcpro.2022.100248] |
| 5. Yanan Yan, Lin Li, Huilin Zhang, Fangfang Du, Yating Meng, Shaomin Shuang, Ruibing Wang, Shengmei Song, Chuan Dong. (2021) Carbon dots for ratiometric fluorescence detection of morin. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:33819765] [10.1016/j.saa.2021.119751] |
| 6. Xueqing Guo, Yang Liu, Wenjuan Dong, Qin Hu, Yong Li, Shaomin Shuang, Chuan Dong, Lishuai Cai, Xiaojuan Gong. (2021) Azithromycin detection in cells and tablets by N,S co-doped carbon quantum dots. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:33561684] [10.1016/j.saa.2021.119506] |
| 7. Tianyu Cui, Xiuping Li, Suyun He, Danhan Xu, Li Yin, Xiaoling Huang, Siwei Deng, Wanqing Yue, Wenying Zhong. (2020) Instant Self-Assembly Peptide Hydrogel Encapsulation with Fibrous Alginate by Microfluidics for Infected Wound Healing. ACS Biomaterials Science & Engineering, [PMID:33455293] [10.1021/acsbiomaterials.0c00581] |
| 8. Yunlei Zhou, Fei Li, Hanwen Wu, Yan Chen, Huanshun Yin, Shiyun Ai, Jun Wang. (2019) Electrochemical aptasensing strategy for kanamycin detection based on target-triggered single-strand DNA adsorption on MoS2 nanosheets and enzymatic signal amplification. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2019.126664] |
| 9. Zhou Yunlei, Sui Chengji, Yin Huanshun, Wang Yue, Wang Minghui, Ai Shiyun. (2018) Tungsten disulfide (WS2) nanosheet-based photoelectrochemical aptasensing of chloramphenicol. MICROCHIMICA ACTA, 185 (10): (1-8). [PMID:30209622] [10.1007/s00604-018-2970-8] |
| 10. Wang Hai-Bo, Li Yang, Bai Hong-Yu, Zhang Zi-Ping, Li Yong-Hong, Liu Yan-Ming. (2018) Development of Rapid and Label-Free Fluorescence Sensing of Tetracyclines in Milk Based on Poly(Adenine) DNA-Templated Au Nanoclusters. Food Analytical Methods, 11 (11): (3095-3102). [PMID:] [10.1007/s12161-018-1289-8] |
| 11. Chengji Sui, Yunlei Zhou, Mengying Wang, Huanshun Yin, Po Wang, Shiyun Ai. (2018) Aptamer-based photoelectrochemical biosensor for antibiotic detection using ferrocene modified DNA as both aptamer and electron donor. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2018.03.171] |
| 12. Yi Xiao, Linru Xu, Ping Li, Xiao-Chong Tang, Lian-Wen Qi. (2017) A simple microdroplet chip consisting of silica nanochannel-assisted electrode and paper cover for highly sensitive electrochemiluminescent detection of drugs in human serum. ANALYTICA CHIMICA ACTA, [PMID:28811034] [10.1016/j.aca.2017.06.014] |
| 13. Joel Isanga, Daniel Mukunzi, Yanni Chen, Steven Suryoprabowo, Liqiang Liu, Hua Kuang. (2017) Development of a monoclonal antibody assay and immunochromatographic test strip for the detection of amikacin residues in milk and eggs. FOOD AND AGRICULTURAL IMMUNOLOGY, [PMID:] [10.1080/09540105.2017.1309361] |
| 14. Panpan Gai, Chengcheng Gu, Ting Hou, Feng Li. (2017) Ultrasensitive Self-Powered Aptasensor Based on Enzyme Biofuel Cell and DNA Bioconjugate: A Facile and Powerful Tool for Antibiotic Residue Detection. ANALYTICAL CHEMISTRY, [PMID:28208296] [10.1021/acs.analchem.6b05109] |
| 15. Yi Zheng, Hanyu Yang, Qiang Yang, Yingying Li, Pran Gopal Karmaker, Xiupei Yang. (2024) A water-stable terbium-based MOF fluorescence sensor for rapid and highly sensitive quantitative detection of cefixime. DYES AND PIGMENTS, [PMID:] [10.1016/j.dyepig.2024.112340] |
| 16. Zhi Li, Shuangying Li, Liushan Jiang, Junping Xiao, Jingwen Niu, Yue Zhang, Chunmao Chen, Qingxiang Zhou. (2024) Construction of nitrogen-doped carbon dots-based fluorescence probe for rapid, efficient and sensitive detection of chlortetracycline. CHEMOSPHERE, [PMID:38844108] [10.1016/j.chemosphere.2024.142535] |
| 17. Yaowei Zhu, Ruijie Tang, Jun Zhao, Changlong Jiang, Lingfei Li, Bianhua Liu. (2025) Design and application of metal-organic framework based chemo-fluorescent sensor for selective sensing of the full spectrum of tetracyclines in complex samples. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.160281] |
| 18. Xinyi Wang, Jing Wang, Houcheng Ding, Yongping Dong. (2025) Detection of acetylcholinesterase based on ECL resonance energy transfer between luminol and gold nanoparticle decorated covalent organic framework. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2025.112774] |
| 19. Chang Tang, Rui Tong, Guoqing Deng, Jing Yang, Yi Zhang, Zhifeng Cai. (2024) Fluorescent carbon dots for highly sensitive diosmetin sensing. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2024.110362] |
| 20. Quanliang Li, Xin Wang, Xiyu Wang, Xiaomeng Wang, Dengyi Ye, Ping Chen, Dayong Ren. (2024) Hypersensitive colorimetric assay based on microbial inhibition for the detection of multiple antibiotics. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, [PMID:] [10.1016/j.jfca.2024.106579] |
| 21. Ruijie Tang, Lingfei Li, Yaowei Zhu, Minghui Zhan, Jun Zhao, Changlong Jiang, Bianhua Liu. (2025) Ratiometric fluorescent sensor for sensitive visualization of full-spectrum fluoroquinolone antibiotic residues in the environment. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2025.113260] |
| 22. Xiaohui Chen, Jing Wen, Xueling Shan, Wenchang Wang, Zhidong Chen. (2024) Supersensitive detection of lincomycin with an ECL aptasensor based on the synergistic integration of gold-functionalized upconversion nanoparticles and thiolated 3,4,9,10-perylene tetracarboxylic acid. ANALYST, 149 (6): (1746-1752). [PMID:38349197] [10.1039/D3AN02169F] |
| 23. Liyun Ma, Zhi Li, Yiyi Shi, Yuchen Xie, Ming Jiang, Xu Yu, Li Xu. (2024) Two Birds With One Stone: A Novel Nanocomposite Combining Silicon Nanoparticles and Carbon-Doped Titania as the Fluorescence Probe and Visible Light Photocatalyst for Simultaneous Detection and Removal of Oxytetracycline. Advanced Science, [PMID:39651852] [10.1002/advs.202410306] |
| 24. Wenjuan Dong, Lu Wang, Rongrong Zhang, Chaochao Wen, Ren Su, Xiaojuan Gong, Wenting Liang. (2023) High luminescent N,S,P co-doped carbon dots for the fluorescence sensing of extreme acidity and folic acid. DALTON TRANSACTIONS, 52 (19): (6551-6558). [PMID:37185994] [10.1039/D3DT00560G] |
| 25. Li Zhang, Huaizhong Xing, Wei Liu, Zihan Wang, Yumin Hao, Huiping Wang, Wenjuan Dong, Yang Liu, Shaomin Shuang, Chuan Dong, Xiaojuan Gong. (2021) 11-Mercaptoundecanoic Acid-Functionalized Carbon Dots As a Ratiometric Optical Probe for Doxorubicin Detection. ACS Applied Nano Materials, [PMID:] [10.1021/acsanm.1c03141] |
| 26. Zhi Li, Shuangying Li, Liushan Jiang, Jingwen Niu, Yue Zhang, Linchun Nie, Qingxiang Zhou, Chunmao Chen. (2024) High enrichment and sensitive measurement of oxytetracycline in tea drinks by thermosensitive magnetic molecular imprinting based magnetic solid phase extraction coupled with boron doped carbon dots. FOOD CHEMISTRY, [PMID:38503068] [10.1016/j.foodchem.2024.138998] |
| 27. Menglong Liu, Litao Chen, Jinyang Li, Jiayan Gao, Xue Gao. (2025) A biosensor based on Mn, Ce doped carbon dots with oxidase-like activity for multi-mode detection of ofloxacin. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2025.138606] |
| 28. Longmei Yao, Jiajia Zhi, Wenchang Wang, Qingyi Li, Ding Jiang, Xiaohui Chen, Zhidong Chen. (2025) An efficient ECL aptasensor based on resonance energy transfer between NCDs@Ag3PO4 and Cu-doped Cu: Eu MOF for the detection of diethylstilbestrol. BIOELECTROCHEMISTRY, [PMID:40222299] [10.1016/j.bioelechem.2025.108987] |
| 29. Tongtong Ma, Qiao Huang, Lei Yuan, Shugang Yan, Yalin Mo, Yibin Ying, Yingchun Fu, Jinming Pan. (2025) Tailored Fluorescent Metal–Organic Frameworks Hybrid Membrane Sensor Arrays: Simultaneous and Selective Quantification of Multiple Antibiotics. Advanced Science, [PMID:40285681] [10.1002/advs.202502452] |
| 30. Wenxiao Liu, Guohao Chen, Yue Li, Hongpo Dong. (2025) Development of a whole-cell biosensor for the detection of low concentrations of tetracycline. Journal of Environmental Sciences, [PMID:41177646] [10.1016/j.jes.2025.06.018] |
| 31. Meiling Xu, Linchun Nie, Jiawei Liao, Dejing Meng, Wenjing Liu, Haobo Yang, Ranhao Zhao, Qingxiang Zhou. (2025) Visible ratiometric fluorescence sensor based on Mg, N-CDs@ZIF-8 for sensitive detection of oxytetracycline and discrimination of tetracycline antibiotics. CHEMICAL ENGINEERING SCIENCE, [PMID:] [10.1016/j.ces.2025.123206] |
| 32. Hong Khanh Trung, Dang Huu Phuc, Le Hanh Ngoc Thi, Dieu Nguyen, Duyen Ky, Nguyen Quoc Thang, Nguyen Van Cuong. (2026) Microwave-assisted synthesis of nitrogen-doped carbon quantum dots for dual fluorescence detection of Fe³⁺ ions and oxytetracycline. APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 132 (3): (226). [PMID:] [10.1007/s00339-026-09425-1] |
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